A5084126232- Hepatitis B Virus Studies
- interferon and immune responses
- Hepatitis C virus research
- Immune Response and Inflammation
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related gene regulation
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Viral Infections and Immunology Research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
Wuhan University
2016-2025
Zhejiang Chinese Medical University
2022-2025
Guangdong Academy of Agricultural Sciences
2025
Sichuan University
2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
West China Hospital of Sichuan University
2025
Shanghai Sunshine Rehabilitation Center
2025
Shanghai University of Sport
2025
Zhongnan Hospital of Wuhan University
2008-2024
Abstract Glucose metabolism and innate immunity evolved side-by-side. It is unclear if how the two systems interact with each other during hepatitis B virus (HBV) infections and, so, which mechanisms are involved. Here, we report that HBV activates glycolysis to impede retinoic acid-inducible gene I (RIG-I)-induced interferon production. We demonstrate sequesters MAVS from RIG-I by forming a ternary complex including hexokinase (HK). Using series of pharmacological genetic approaches,...
Abstract Colorectal cancer (CRC) is a heterogeneous disease that develops through stepwise accumulation, yet the underlying mechanisms at single-cell resolution remain unclear. Here, we profiled 751,531 transcriptomes, spatial transcriptomics, and snMultiomes from 142 multistage samples, revealing cellular molecular alterations dynamic intercellular crosstalk during CRC development. Additionally, created sc-eQTL map identifying 16,833 significant pairs across 28 cell subtypes, with over 76%...
ABSTRACT The expression of the genomic information severe acute respiratory syndrome coronavirus (SARS CoV) involves synthesis a nested set subgenomic RNAs (sgRNAs) by discontinuous transcription. In SARS CoV-infected cells, 10 sgRNAs, including 2 novel ones, were identified, which predicted to be functional in 12 open reading frames located 3′ one-third genome. Surprisingly, one new sgRNA could lead production truncated spike protein. Sequence analysis leader-body fusion sites each showed...
Regulated gene expression and progeny production are essential for persistent chronic infection by human pathogens, such as hepatitis B virus (HBV), which affects >400 million people worldwide is a major cause of liver disease. In this study, we provide the first direct evidence that liver-specific microRNA, miR-122, binds to highly conserved HBV pregenomic RNA sequence via base-pairing interactions inhibits replication. The miR-122 target located at coding region mRNA viral polymerase 3'...
A conserved guanine-rich sequence could be a new target for anti–hepatitis C virus drug development.
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. Porphyromonas gingivalis, Treponema denticola Tannerella forsythia have all been playing roles in P. gingivalis cell-surface-located protease/adhesins, the gingipains, suggested be involved its with several other species. The aims of this study were determine formation by T. forsythia, well role gingipains using gingipain...
In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)-associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)-induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induced production. Upon investigating mechanisms driving event, determined that IAV induced OGT to bind interferon regulatory factor-5 (IRF5), leading O-GlcNAcylation IRF5 on serine-430. is required...
The individual effects of early-life tobacco smoke exposure and its interactions with genetic factors on lung cancer in adulthood remain unclear.
It is well established that p300 plays an important role in mediating gene expressions. However, it less clear how its binding influenced by physiological stimuli and altered affects transactivator acetylation binding. In this study, we determined to a core cyclooxygenase-2 (COX-2) promoter region chromatin immunoprecipitation streptavidin-agarose pull-down assays basal tumor necrosis factor-α (TNFα)-treated human foreskin fibroblasts. We found of p300, p50/p65 NF-κB, cyclic AMP regulatory...
Abstract Our previous studies with clinical data analysis have shown that the proinflammatory factor IL-32 is activated in response to influenza virus infection. However, little known about how induces production, and role of host immune responses during viral infection remains unclear. In this study, we show production stimulated by A or dsRNA human PBMCs from healthy volunteers. We demonstrate NF-κB CREB pathways play key roles activation A549 lung epithelial cells. then aberrant...
Lambda-1 interferon (IFN-λ1) and cyclooxygenase-2 (COX-2) were reported to play an important role in host antiviral defense. However, the mechanism by which IFN-λ1 COX2 are activated modulated during viral infection remains unclear. In this study, we found that expression of both circulating COX2-derived prostaglandin E2 (PGE2) was coordinately elevated a cohort influenza patients compared healthy individuals. Expression blocked selective inhibitor A virus A549 human lung epithelial cells...
During influenza A virus (IAV) infection, cytokine storms play a vital and critical role in clinical outcomes. We have previously reported that microRNA (miR)-302c regulates IAV-induced IFN expression by targeting the 3'-UTR of nuclear factor κB (NF-κB)-inducing kinase. In current study, we found miR-302a, another member miR-302 cluster, controls storm. According to results from cell-based knockout mouse models, IAV induces storm via interferon regulatory factor-5 (IRF-5). also infection...
The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions innate immunity during viral infections. In this study, we found that infections resulted elevated levels of 90K. Further studies demonstrated expression suppressed virus replication by inducing IFN and pro-inflammatory cytokine production. Upon investigating the mechanisms behind event,...
Abstract Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression cancer, suggesting that genetic determinants might play an important role in regulating cancer risk. Here, we depicted pan-cancer atlas human quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 types. Systematic multiomics analyses indicated could contribute to regulation by altering poly(A) motifs,...
BackgroundInterleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little known about IL-32 production exogenous pathogens infection human individuals.Methods and FindingsIn this study, we found level was increased 58.2% the serum samples from cohort of 108 patients infected influenza A virus comparing 115 healthy individuals. Another factor cyclooxygenase (COX)-2-associated prostaglandin E2 also...
ABSTRACT We have previously shown that the nucleocapsid protein of SARS‐associated coronavirus (SARS‐CoV) activated cyclooxygenase‐2 (COX‐2) expression (1). In this study, we identified another viral protein, spike SARS‐CoV, which played an important role in virus‐stimulated COX‐2 after screening all genes from SARS‐CoV genome. found upstream calcium‐dependent PKC isozyme PKCα modulates downstream ERK/ NF‐κB pathway through influx extracellular Ca 2+ is induced by SARS‐CoV. The ERK/NF‐κB was...
Chronic inflammation induced by hepatitis B virus (HBV) is a major causative factor associated with the development of cirrhosis and hepatocellular carcinoma. In this study, we investigated roles three inflammatory factors, IL-8, IL-29 (or IFN-λ1), cyclooxygenase-2 (COX-2), in HBV infection. We showed that expression IL-29, COX-2 genes was enhanced HBV-infected patients or HBV-expressing cells. HBV-transfected human lymphocytes hepatocytes, activates production which turn enhances COX-2....