A5078336294- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Fibroblast Growth Factor Research
- Eosinophilic Disorders and Syndromes
- Gene expression and cancer classification
- Skin and Cellular Biology Research
- Genomics and Phylogenetic Studies
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Antibiotic Use and Resistance
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Advanced Image Processing Techniques
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- Metabolomics and Mass Spectrometry Studies
- Steroid Chemistry and Biochemistry
- Hair Growth and Disorders
- Semantic Web and Ontologies
- Infective Endocarditis Diagnosis and Management
- Image and Signal Denoising Methods
- Tuberculosis Research and Epidemiology
- Animal Genetics and Reproduction
Chinese Academy of Sciences
2023-2025
University of Chinese Academy of Sciences
2023-2024
Aerospace Information Research Institute
2024
Anhui Medical University
2021-2023
First Affiliated Hospital of Anhui Medical University
2022
Fourth Affiliated Hospital of Anhui Medical University
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2017-2020
Sichuan University
2015-2017
West China Hospital of Sichuan University
2015-2017
Faecalibacterium prausnitzii is a beneficial human gut microbe and candidate for next-generation probiotics. With probiotics now being used in clinical treatments, concerns about their safety side effects need to be considered. Therefore, it essential obtain comprehensive understanding of the genetic diversity, functional characteristics, potential risks different F. strains. In this study, we collected information 84 F . strains conduct pan-genome analysis with multiple perspectives. Based...
Antibiotic resistance genes (ARGs) are emerging pollutants present in various environments. Identifying ARGs has become a growing concern recent years. Several databases, including the Resistance Genes Database (ARDB), Comprehensive (CARD), and Structured (SARG), have been applied to detect ARGs. However, these databases limitations, which hinder comprehensive profiling of environmental samples. To address issues, we constructed non-redundant antibiotic database (NRD) by consolidating...
Abstract Topical immunotherapy with diphenylcyclopropenone (DPCP) is considered to be the most effective treatment of severe AA. However, mechanism unclear and an early predictor for efficacy needs explored. The TSLP/OX40L/IL‐13 pathway important initiate maintain Th2 immune responses. Our previous work suggests this may play a role in AA treated DPCP. Thus, further investigate DPCP explore therapy, we conducted prospective study compare expression levels TSLP, OX40L, cytokines IL‐4, IL‐5...
Skin-derived precursors (SKPs) from dermis possess the capacities of self-renewal and multipotency. In vitro in vivo studies demonstrated that they can differentiate into fibroblasts. However, little is known about molecular mechanism differentiation SKPs Here we compare transcriptomes mouse SKP-derived fibroblasts (SFBs) by RNA-Seq analysis, trying to find differences gene expression between two kinds cells then elucidate candidate genes may play important roles A total 1971 differentially...
Gut microbiota plays an essential role in the development of rheumatoid arthritis (RA) and affects drug responses. However, underlying mechanism remains elusive urgent to elucidate explore pathology clinical treatment RA. Therefore, we selected methotrexate (MTX) as example RA drugs interactions between gut responses obtain in-depth understanding their correlation from perspective metabolic capability on metabolism. We identified 2,654 proteins corresponding genes involved MTX metabolism...
Antibiotics resistance genes (ARGs) are mainly caused by the extensive use and abuse of antibiotics have become a global public health concern. Owing to development high-throughput sequencing, metagenomic sequencing has been widely applied profile composition ARGs, investigate their distribution pattern, track sources in diverse environments. However, lack detailed transmission mechanism ARGs limits management its pollution. Hence, it’s essential introduce how utilize data obtain an in-depth...
Skin-derived precursors (SKPs) display the characteristics of self-renewal and multilineage differentiation.The study aimed to explore molecular mechanisms mouse SKPs differentiation into SKP-derived fibroblasts (SFBs).We compared microRNA (miRNA) profile in SFBs by RNA sequenc-ing. Real-time quantitative reverse transcription PCR (qRT-PCR) was performed validate miRNA expression. The integrated analysis mRNA expression data potential crosstalk miRNA-mRNA SKP differentiation.207...
Skin-derived precursors (SKPs) can differentiate into fibroblasts. However, little is known about the molecular mechanism of differentiation process. Our previous study has compared transcriptomes mouse SKPs and SKP-derived fibroblasts (SFBs) by RNA-Seq analysis found some genes signal pathways that might play important roles in transition from to SFBs. Here, further investigate process which fibroblasts, we proteomes between SFBs using iTRAQ. results showed 243 differentially expressed...
Transformer-based methods have demonstrated impressive performance in image super-resolution tasks. However, when applied to large-scale Earth observation images, the existing transformers encounter two significant challenges: (1) insufficient consideration of spatial correlation between adjacent ground objects; and (2) bottlenecks due underutilization upsample module. To address these issues, we propose a novel distance-enhanced strip attention transformer (DESAT). The DESAT integrates...
Antibiotic resistance genes (ARGs) have been recognized as an emerging pollutant that is widely distributed and accumulated in various environmental niches. The identification of ARGs has attracted more concern became issue. In past decades, several bioinformatic databases, including Resistance Genes Database (ARDB), Comprehensive (CARD), Structured (SARG), were constructed applied to utilize metagenome approaches for elucidating ARGs. However, limitations still existed these databases due...