A5101952506- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Management of metastatic bone disease
- Molecular Biology Techniques and Applications
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Musculoskeletal synovial abnormalities and treatments
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Surgical site infection prevention
- Bone and Dental Protein Studies
- Reconstructive Surgery and Microvascular Techniques
- Nanowire Synthesis and Applications
- Breast Cancer Treatment Studies
- Soft tissue tumors and treatment
Beijing Jishuitan Hospital
2016-2024
Capital Medical University
2023-2024
Peking University
2015-2024
Beijing Tian Tan Hospital
2012-2024
Peking University People's Hospital
2015-2023
Weatherford College
2020
Early Manuscripts Electronic Library
2018-2020
Nantong University
2016
Taizhou People's Hospital
2016
Harbin Medical University
2013
Abstract Background The therapeutic application of chimeric antigen receptor (CAR) T cells in T-cell malignancies faces substantial limitations owing to fratricide and potential cell aplasia, primarily attributed the shared expression target antigens, such as CD5, between normal malignant cells. Although natural killer (NK) cell-based immunotherapy is a promising alternative approach, its efficacy treating hematologic remains be fully elucidated. Methods CD5-targeted CAR-modified primary NK...
Abstract The aim of this nonrandomized controlled study (level 3)was to evaluate whether preoperative denosumab treatment can reduce intraoperative blood loss, facilitate surgical treatment, and improve local control sacral giant-cell tumor (GCT). Surgical GCT is very difficult due extensive bone destruction complex anatomical structures. huge loss may interrupt management judgment range. Denosumab inhibit the differentiation osteoclast-like giant cells by blocking RANKL-RANK pathway. Study...
Pulmonary metastasis of benign giant cell tumor bone is very rare, and its biological behavior difficult to predict. In the present study, we analyzed clinical characteristics related risk factors for pulmonary this tumor. Forty-six patients with lung were analyzed. total, 60.9% primary tumors located around knee joint. The Campanacci stage all was 3. Surgery included curettage in 37 patients, resection 8, amputation 1. Local recurrence after surgery occurred 34 patients. rate, stage,...
Malignancy in giant cell tumor of bone (GCTB) is a rare with relevant literature being sparse. In primary malignant GCTB, distinct areas benign GCTB are juxtaposed high-grade sarcoma, while secondary sarcoma occurs at the site previously managed GCTB. This study assesses distinguishing characteristics patients this condition, time interval for development outcome treatment, and explores factors associated oncologic outcomes. retrospective case series from prospectively collected...
Acute myeloid leukemia (AML) treatment remains challenging. CD70 was reported as a promising AML-specific antigen. Preclinically, CAR T-cell with single-chain-variable fragment (scFv) or truncated CD27 targeting has been to treat AML. However, various disadvantages including spontaneous exhaustion, proteinase-mediated loss of functional receptors, and high immunogenicity, limited its further application clinical settings. Alternatively, the single-variable domain on heavy chain (VHH), also...
Denosumab is gradually applied to refractory or unresectable giant cell tumour of the bone. Whether denosumab can effectively reduce blood supply and bring benefit worthy study. The aim study evaluate related changes after treatment: supply, surgical plan downstaging, difficulty oncological prognosis.A self-case-control was performed from June 2014 November 2016, 18 patients were enrolled. Patients received subcutaneous 120 mg every 4 weeks preoperatively, with additional doses administered...
Abstract Surgical treatment of malignant bone tumors comprises tumor resection and reconstruction. The most commonly used reconstruction method is prosthesis replacement, which achieves good early function, but has a high long-term incidence complications. Another option autologous replantation, the advantages anatomical matching no need for large bank support. Few studies have evaluated with liquid nitrogen-inactivated autogenous bone. present study aimed to evaluate oncological results,...
Background: Resection of sacral chordomas is challenging. The anatomy complex, and there are often no bony landmarks to guide the resection. Achieving adequate surgical margins is, therefore, difficult, recurrence rate high. Use computer navigation may allow optimal preoperative planning improve precision in tumor purpose this study was evaluate safety feasibility navigation-aided resection chordomas. Methods: Between 2007 2013, a total 26 patients with chordoma underwent surgery were...
We determined the efficacy of a devitalised autograft (n = 13) and allograft 16) cortical strut bone graft combined with long-stem endoprosthetic reconstruction in treatment massive tumours lower limb. A total 29 patients (18 men:11 women, mean age 20.1 years (12 to 45) ratio length resection that whole prosthesis > 50% were treated between May 2003 2012. The follow-up was 47 months (15 132). stem introduced through struts filled cement, then cemented into residual bone. Bone healing...
Abstract Case series. To analyze the clinical results and related factors of further surgical treatment for recurrent sacral chordomas. Chordomas are rare primary malignant tumors with a high recurrence rate. The is difficult controversial. Contamination by previous operations disturbed local anatomical structures may increase risk reoperation. Most studies have focused on tumor; there very few reports diagnosis, treatment, prognosis Thirty-four patients chordomas from 1979 to 2014 were...
We analysed the survival, complications, and function of frozen autograft augmented with intramedullary cement bridging plates fixation for intercalary bone defect reconstruction in primary sarcomas.
Osteosarcoma is the most prevalent clinical malignant bone tumor in adolescents. The prognosis of metastatic osteosarcoma still very poor. aim our study was to investigate diagnosis and prognostic significance metastasis related genes (MRGs) patients with osteosarcoma. Clinical information RNA sequencing data were obtained set as training from UCSC databases. GSE21257 downloaded chosen verification cohort. An eight gene risk signature including MYC, TAC4, ABCA4, GADD45GIP1, TNFRSF21, HERC5,...
Sarcomas are classified into two types, bone sarcoma and soft tissue (STS), which account for approximately 1% of adult solid malignancies 20% pediatric malignancies. There exist more than 50 subtypes within the types sarcoma. Each subtype is highly diverse characterized by significant variations in morphology phenotypes. Understanding tumor molecular genetics helpful improving diagnostic accuracy tumors that have been difficult to classify based on alone or overlapping morphological...
Aim of Study: In this study, we detected epithelial circulating tumor cells (CTCs) that expressed cytokeratins and potential (pCTCs) had lost expression in metastatic breast cancer (MBC) patients. The aim the study was to evaluate prognostic significance these two kinds CTCs MBC Materials Methods: We pCTCs from 66 patients using MACS immunomagnetic enrichment technology combined with immunocytochemistry (ICC). A cutoff score 5 (or pCTCs) set as a benchmark for prognosis Progression free...
Analysis of the tumour necrosis rate is an important method to evaluate effect neoadjuvant chemotherapy for osteosarcoma. However, at present, there no specific imaging this effect. The purpose study was changes in blood supply after by measuring CT enhancement and analyse correlation between rate.Patients with primary osteosarcoma extremities treated our institute from 2016 2017 were analysed retrospectively. In total, 103 eligible patients enrolled study, including 67 males 36 females,...