A5055964666- Smart Grid Energy Management
- Microgrid Control and Optimization
- Power System Optimization and Stability
- Optimal Power Flow Distribution
- Circular RNAs in diseases
- Electric Power System Optimization
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Frequency Control in Power Systems
- Ginseng Biological Effects and Applications
- Power Systems and Renewable Energy
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Smart Grid Security and Resilience
- Cancer-related gene regulation
- Reinforcement Learning in Robotics
- Liver Diseases and Immunity
- Berberine and alkaloids research
- Epigenetics and DNA Methylation
- Energy Load and Power Forecasting
- Drug Transport and Resistance Mechanisms
- Energy Efficiency and Management
- Power System Reliability and Maintenance
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2016-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Laboratory of Molecular Genetics
2018-2021
National Taiwan University
2021
University of Jinan
2021
ORCID
2020
University of Illinois Urbana-Champaign
2014-2020
Nanjing Institute of Technology
2020
Mitsubishi Electric (United States)
2019
Indiana University – Purdue University Indianapolis
2018
One of the primary mechanisms tumor cell immune evasion is loss antigenicity, which arises due to lack immunogenic antigens as well dysregulation antigen processing machinery. In a screen for small-molecule compounds from herbal medicine that potentiate T cell-mediated cytotoxicity, we identified atractylenolide I (ATT-I), substantially promotes presentation both human and mouse colorectal cancer (CRC) cells thereby enhances cytotoxic response CD8+ cells. Cellular thermal shift assay (CETSA)...
Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors the digestive system. Portulaca oleracea L. (POL), in TCM thousands years. The chemical composition POL is variable includes flavonoids, alkaloids, terpenoids organic acids other classes natural compounds. Many these compounds exhibit powerful anti-inflammatory anti-cancer-transforming effects In this review, we focus on potential therapeutic role NASH, gastritis colitis their...
This paper proposes a closed-loop identification method to estimate the equivalent inertia constant of power system at connection bus. A microperturbation is first performed with well-designed multisine signal probed through any electronic devices in internal system. Then, responses frequency and active measured by phase measurement unit bus are used for identification. Compared conventional transient based method, proposed has simple implementation minimum impacts on security, thus could be...
In this paper, we address the problem of setting tap positions load changers (LTCs) for voltage regulation in radial power distribution systems under uncertain dynamics. The objective is to find a policy determine that only uses measurements magnitudes and topology information so as minimize deviation across system. We formulate Markov decision process (MDP), propose batch reinforcement learning (RL) algorithm solve it. By taking advantage linearized flow model, an effective estimate...
Abstract Background Circular RNAs (circRNAs), important members of the noncoding RNA family, have been recently revealed to play a role in pathogenic progression diseases, particularly malignant cancer. With application high-throughput sequencing technology, large number circRNAs identified tumor tissues, and some demonstrated act as oncogenes. In this study, we analyzed circRNA expression profile colorectal cancer (CRC) tissues normal adjacent by sequencing. We focused on circRNA_0000392,...
Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed new therapeutic agent berberine compounds (BC), consisting berberine, oryzanol vitamin B6, determined their anti-hyperlipidemia activity underlying mechanisms. Male Wistar rats were fed high fat diet (HFD) to induce hyperlipidemia, then given BC orally for 4 weeks. Body weight food intake recorded weekly, lipid profiles in serum biochemically. Metabolites serum, urine, liver...
In this paper, we address the problem of jointly determining energy bid submitted to wholesale electricity market (WEM) and price charged in retailed (REM) for a load serving entity (LSE). The joint bidding pricing is formulated as Markov decision process (MDP) with continuous state action spaces which are two actions that share common objective. We apply deep deterministic policy gradient (DDPG) algorithm solve MDP optimal policies. Yet, DDPG typically requires significant number transition...
In this paper, we develop a data-driven framework for controlling distributed energy resources (DERs) in balanced radial power distribution system with the objective of regulating voltages across whole system. The is to determine optimal DER injections that minimize voltage excursions outside desirable range without knowing complete model To end, approximate nonlinear relationship between magnitudes and by linear model. parameters model-referred as sensitivities-can be computed using...
Maintaining an accurate power system model is crucial for a variety of applications such as electricity markets. In this paper, the cyber security issue induced by critical parameters in market operations investigated. Critical are set errors which cannot be detected due to lack local measurements. it first proven that criticality property independent from operating points, i.e., maliciously injected will always remain undetectable. Then, attack against formulated bilevel programming problem...
Colorectal carcinoma (CRC) is the third most common cancer and second cause of cancer-related deaths worldwide. Ribonucleic acid (RNA) N6-methyladnosine (m6A) methyltransferase-like 3 (METTL3) play key roles in progression. However, m6A METTL3 CRC progression require further clarification.Adenoma samples were examined to detect levels, tissue microarrays performed evaluate association levels with survival patients CRC. The biological functions investigated through cell counting kit-8, wound...
Battery Energy Storage System (BESS) can be utilized to shave the peak load in power systems and thus defer need upgrade grid. Based on a rolling forecasting method, along with reduction requirements reality, at planning level, we propose BESS capacity model for shaving problem. At operational consider optimal control policy towards charging discharging two different optimization objectives: one is diminish difference between valley load, other minimize daily variance. Particularly,...
// Hua Sui 1, * , Hanchen Xu 2, Qing Ji 1 Xuan Liu Lihong Zhou Haiyan Song 2 Xiqiu Yangxian Zhesheng Chen 3 Jianfeng Cai 4 Guang Qi Li Department of Medical Oncology, Shuguang Hospital, Shanghai University Traditional Chinese Medicine, 201203, China Institute Digestive Diseases, Longhua medicine, 200032, Pharmaceutical Sciences, College Pharmacy and Health St. John's University, Queens, NY 11439, USA Chemistry, South Florida, Tampa, FL 33620, These authors have contributed equally to this...
Chromosome 17q23 amplification occurs in ~11% of human breast cancers. Enriched HER2+ cancers, the is significantly correlated with poor clinical outcomes. In addition to previously identified oncogene WIP1, we uncover an oncogenic microRNA gene, MIR21, a majority WIP1-containing amplicons. The results aberrant expression WIP1 and miR-21, which not only promotes tumorigenesis, but also leads resistance anti-HER2 therapies. Inhibiting miR-21 selectively inhibits proliferation, survival...
Heterozygous deletion of chromosome 17p (17p) is one the most frequent genomic events in human cancers. Beyond tumor suppressor TP53, POLR2A gene encoding catalytic subunit RNA polymerase II (RNAP2) also included a ~20-megabase region 63% metastatic castration-resistant prostate cancer (CRPC). Using focused CRISPR-Cas9 screen, we discovered that heterozygous loss confers selective dependence CRPC cells on ubiquitin E3 ligase Ring-Box 1 (RBX1). RBX1 activates by K63-linked ubiquitination and...
The adaptive learning problem concerns how to create an individualized plan (also referred as a policy) that chooses the most appropriate materials based on learner’s latent traits. In this article, we study important yet less-addressed problem—one assumes continuous Specifically, formulate Markov decision process. We assume traits be with unknown transition model and apply model-free deep reinforcement algorithm—the Q-learning algorithm—that can effectively find optimal policy from data...
Background Colorectal cancer (CRC) ranks among the most common gastrointestinal cancers globally, with both its incidence and mortality rates showing an upward trend. In particular, 5-year survival rate for stage IV CRC patients is only 14%. Conventional treatments such as chemotherapy immunotherapy can lead to drug resistance, exacerbate function damage, induce immunosuppression. Sijunzi decoction (SJZD), a fundamental formula of Traditional Chinese medicine (TCM), has been demonstrated...
Immune checkpoint inhibitors (ICIs) have shown limited efficacy in colorectal cancer (CRC). Chinese yam polysaccharide (CYP), a naturally derived plant polysaccharide, demonstrates immunomodulatory and antitumour activities. This study investigated whether CYP enhances the effects of αPD-1 monoclonal antibody (mAb) by modulating gut microbiota metabolites. In MC38 CT26 xenograft models, synergistically inhibited tumour growth when combined with mAb. 16S rRNA sequencing revealed that...