A5100447755- Nanoplatforms for cancer theranostics
- Aerogels and thermal insulation
- Advanced Cellulose Research Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Advanced Battery Technologies Research
- RNA Interference and Gene Delivery
- Adsorption and biosorption for pollutant removal
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Nanocluster Synthesis and Applications
- Covalent Organic Framework Applications
- Immune cells in cancer
- Electrospun Nanofibers in Biomedical Applications
- Metal complexes synthesis and properties
- Extracellular vesicles in disease
- Surface Modification and Superhydrophobicity
- Synthesis and properties of polymers
- Solar-Powered Water Purification Methods
- Pickering emulsions and particle stabilization
- Advanced Sensor and Energy Harvesting Materials
- Membrane Separation and Gas Transport
Swiss Federal Laboratories for Materials Science and Technology
2019-2025
Huazhong University of Science and Technology
2014-2025
Agency for Science, Technology and Research
2023-2025
University of Jinan
2022-2025
Union Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
Green Chemistry
2025
Institute of Electronics
2024
Shaanxi University of Technology
2023-2024
Union Hospital
2019-2024
Cancer immunotherapy is mainly focused on manipulating patient's own immune system to recognize and destroy cancer cells. Vaccine formulations based nanotechnology have been developed target delivery antigens antigen presenting cells (APCs), especially dendritic (DCs) for efficiently induction of antigen-specific T response. To enhance DC targeting efficiency, we erythrocyte membrane-enveloped poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles antigenic peptide (hgp10025-33) toll-like...
Ultralight and highly flexible biopolymer aerogels, composed of biomimetic cellular microstructures formed from cellulose nanofibers silver nanowires, are assembled via a convenient facile freeze-casting method. The lamellar, honeycomb-like, random porous scaffolds successfully achieved by adjusting freezing approaches to modulate the relationships between macroscopic mechanical electromagnetic interference (EMI) shielding performances. Combining transformation arising in situ compression...
A biomimetic nanogel with tumor microenvironment responsive property is developed for the combinatorial antitumor effects of chemotherapy and immunotherapy. Nanogels are formulated hydroxypropyl-β-cyclodextrin acrylate two opposite charged chitosan derivatives entrapping anticancer drug paclitaxel precisely controlling pH capability, respectively. The supported erythrocyte membrane can achieve "nanosponge" delivering immunotherapeutic agent interleukin-2 without reducing bioactivity. By...
Abstract Lightweight, ultra-flexible, and robust crosslinked transition metal carbide (Ti 3 C 2 MXene) coated polyimide (PI) (C-MXene@PI) porous composites are manufactured via a scalable dip-coating followed by chemical crosslinking approach. In addition to the hydrophobicity, anti-oxidation extreme-temperature stability, efficient utilization of intrinsic conductivity MXene, interfacial polarization between MXene PI, micrometer-sized pores composite foams achieved. Consequently, show...
Gold nanoparticle (AuNP) has been widely used in cancer photothermal therapy (PTT) for ablating accessible tumor, while it is insufficient inhibiting tumor metastasis and relapse current stage. Here, we first developed a novel immunological AuNP through intracellular generation exocytosis combinatorial PTT immunotherapy. Melanoma B16F10 cells were employed to generate AuNPs then shed trapped vesicles extracellular environment with retained antigens (AuNP@B16F10). By further introducing the...
Polymer aerogels are a promising, non-brittle alternative to silica aerogel, but limited by their very poor high-temperature stability. Polyimide is widely known for its high heat-resistance, however, degree of volume shrinkage common polyimide after exposure temperatures above 200 °C. Here, we present the aerogel-in-aerogel composites that comprise aerogel grains with nanoparticulate microstructure embedded in nanofibrous matrix. The mixing procedure and synthesis protocol were optimized...
Silica aerogels are advanced materials with outstanding properties, including high specific surface area and porosity, low thermal conductivity, density, dielectric constant, refractive index. However, the excellent properties of silica have shown limited utility in industrial applications, primarily as insulation materials, where they hold only a small (1.1–2.6%) market share. The emergence clean energy technologies stimulated renewed interest other aerogels. Here recent advances production...
BL19U1, an energy-tunable protein complex crystallography beamline at the Shanghai Synchrotron Radiation Facility, has emerged as one of most productive MX beamlines since opening to public in July 2015. As October 2023, it contributed over 2000 structures deposited Protein Data Bank (PDB), resulting publication more than 1000 scientific papers. In response increasing interest structure-based drug design utilizing X-ray for fragment library screening, enhancements have been implemented both...
There is accumulating evidence that regulating tumor microenvironment plays a vital role in improving antitumor efficiency.Herein, to remodel immune and elicit synergistic effects, lipid-coated biodegradable hollow mesoporous silica nanoparticle (dHMLB) was constructed with co-encapsulation of all-trans retinoic acid (ATRA), doxorubicin (DOX) interleukin-2 (IL-2) for chemo-immunotherapy.The nanoparticle-mediated combinational therapy provided benign regulation on through activation...
Nanocellulose was used to assist the preparation of ambient pressure dried CNT foams with well-ordered pore microchannels that enable orientation induced tuning their electromagnetic interference shielding performance.
Solar interfacial evaporation is an emerging technology in solar energy harvesting developed to remedy the global crisis and lack of freshwater resources. However, developing fully enhanced thermal management optimize solar-heat utilization efficiency form remains a great challenge. We created synergistic photothermal layer from poly(N-phenylglycine) (PNPG)/MoS2 nanohybrid via electrostatic-induced self-assembly for broad-spectrum efficient absorption. The PNPG/MoS2 system provided effective...
Abstract Glial cell‐dominated inflammatory microenvironment and neuronal damage due to oxidative stress are major impediments the treatment of central nervous degenerative diseases. Herein, a neuroinflammatory regulatory nanoreactor is developed by encapsulating dihydroquercetin (Que) Pt nanozymes (Ptzymes) in mannitol modified poly(lactic‐ co ‐glycolic acid) nanoparticles. The shows enhanced antioxidative activities compared with either Que or Ptzymes alone synergetic effects incorporated...
Abstract Oxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic cause of acute kidney injury (AKI). Development an effective antioxidation system to mitigate oxidative for alleviating AKI remains be investigated. This study presents the synthesis ultra‐small Platinum (Pt) sulfur cluster (Pt 5.65 S), which functions as pH‐activatable prefabricated nanozyme (pre‐nanozyme). pre‐nanozyme releases hydrogen sulfide (H 2 S) and transforms into (Ptzyme) that mimics...
Abstract Additive manufacturing (AM) is widely recognized as a versatile tool for achieving complex geometries and customized functionalities in designed materials. However, the challenge lies selecting an appropriate AM method that simultaneously realizes desired microstructures macroscopic geometrical designs single sample. This study presents direct ink writing 3D printing intricate, high‐fidelity cellulose aerogel forms. The resulting aerogels exhibit tunable anisotropic mechanical...
Abstract Radiation resistance in breast cancer resulting residual lesions or recurrence is a significant cause to radiotherapy failure. Cancer‐associated fibroblasts (CAFs) and radiotherapy‐induced senescent CAFs can further lead radiation tumor immunosuppressive microenvironment. Here, an engineering cancer‐cell‐biomimetic nanoplatform constructed for dual‐targeted clearance of as well CAFs. The prepared by 4T1 cell membrane vesicles chimerized with FAP single‐chain fragment variable the...
Nitric oxide (NO) has attracted much attention for its antitumor activity and synergistic effects when codelivered with anticancer agents. However, due to chemical instability short half-life, delivering gaseous NO directly tumors is still challenging. Herein, we synthesized a releasing polymer, nitrate functionalized d-α-tocopheryl polyethylene glycol succinate (TNO3). TNO3 was able self-assemble into stable micelles in physiological conditions, accumulate tumors, release ∼90% of content...