A5103002348- Advanced Polymer Synthesis and Characterization
- Pickering emulsions and particle stabilization
- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- HIV Research and Treatment
- Astronomy and Astrophysical Research
- Astronomical Observations and Instrumentation
- Stellar, planetary, and galactic studies
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Block Copolymer Self-Assembly
- Luminescence and Fluorescent Materials
- HIV, Drug Use, Sexual Risk
- Influenza Virus Research Studies
- Hepatitis C virus research
- interferon and immune responses
- Hepatitis B Virus Studies
- Nanoparticle-Based Drug Delivery
- Silicone and Siloxane Chemistry
- 2D Materials and Applications
- MXene and MAX Phase Materials
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Polymer Nanocomposites and Properties
- Boron and Carbon Nanomaterials Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2024
Tsinghua University
2007-2024
Sinopec (China)
2024
Energy Research Institute
2024
Hebei Medical University
2020-2023
Fourth Hospital of Hebei Medical University
2020-2023
Drexel University
2014-2023
Anyang Hospital of Traditional Chinese Medicine
2021
National University of Defense Technology
2008-2019
Soochow University
2016
2D transition metal carbides or nitrides, known as MXenes, are a new family of materials with close to 30 members experimentally synthesized and dozens more theoretically investigated. Because the abundant surface terminations, MXenes have been compounded various by multi-interactions. In addition prevented aggregation oxidation MXene flakes, MXene/polymer membranes exhibit outstanding mechanical, thermal, electrical properties due synergistic effects. However, relatively little is currently...
Creating unusual nanostructures Self-assembly often occurs when dissimilar molecular fragments are forced together by covalent bonding. Surfactants or block copolymers two common examples. Huang et al. grafted four different nanoparticles, based on polyhedral oligomeric silsesquioxanes with slightly compositions, onto a single tetrahedal core (see the Perspective Yang). Depending type of nanoparticle, they assembled into range defined, ordered supramolecular lattices similar to metal alloys....
Developing high-performance and reusable adhesives from renewable feedstocks is of significance to sustainable development, yet it still remains a formidable task. Herein, castor oil, melevodopa, iron ions are used as building blocks construct novel bio-based supramolecular adhesive (BSA) with outstanding adhesion performances. It prepared through partial coordination between melevodopa functionalized oil Fe3+ ions. Noncovalent interactions adherends the catechol unit contribute reinforcing...
Abstract As one of the rising 2D materials, niobium‐carbide (Nb 2 C, well‐known as a member MXene family) has attracted considerable attention owing to its unique physical and chemical properties. In this work, few‐layer Nb C nanosheets (NSs) with large (≈255 nm) small (≈48 lateral dimensions are obtained via combination selective etching liquid cascade centrifugation. Their relaxation time photophysics process systematically investigated by transient absorption spectroscopy, size effect is...
Abstract 2D PbS nanoplatelets (NPLs) form an emerging class of photoactive materials and have been proposed as robust for high‐performance optoelectronic devices. However, the main drawback NPLs is large lateral size, which inhibits their further investigations practical applications. In this work, ultra‐small with uniform size (11.2 ± 1.7 nm) thickness (3.7 0.9 nm, ≈6 layers) successfully fabricated by a facile liquid‐phase exfoliation approach. Their transient optical response...
Abstract The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane proteins. MARCH8 has been reported to inhibit infection HIV-1 and a few other viruses, thus plays an important role in host antiviral defense. However, spectrum underlying mechanisms incompletely defined. Here, we demonstrate profoundly inhibits influenza A virus (IAV) replication both vitro mice. Mechanistically, suppresses IAV release through redirecting viral...
We report a supramolecular naphthalene diimide (NDI) radical anion with efficient NIR-II photothermal conversion for E. coli-responsive therapy. The (NDI-2CB[7])⋅- , which is obtained from the coli-induced in situ reduction of NDI-2CB[7] neutral complex, formed by host-guest interaction between an NDI derivative and cucurbit[7]uril (CB[7]), exhibits unexpectedly strong absorption remarkable capacity aqueous solution. caused self-assembly anions to form dimer radicals solution, supported...
China is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C (HCV) infection due to large numbers paid blood donors (PBD), injection drug users (IDU), sexual partners infected individuals. In this report, total 236 HIV-1-positive samples were collected from PBD, IDU, their the most severely affected provinces, such as Henan, Yunnan, Guangxi, Xinjiang. PCR was used amplify p17 region gag C2-V3 env HIV-1 5' noncoding E1/E2 HCV. Genetic...
Abstract Lipids and amphiphilic block copolymers spontaneously self-assemble in water to form a plethora of micelles vesicles. They are typically fluidic nature often mechanically weak for applications such as drug delivery gene therapeutics. Mechanical properties polymeric materials could be improved by forming crystalline structures. However, most the self-assembled vesicles have curved surfaces precisely tuning crystallization within nanoscale space is challenging, geometry incommensurate...
Abstract In water, amphiphilic block copolymers (BCPs) can self-assemble into various micelle structures depicting curved liquid/liquid interface. Crystallization, which is incommensurate with this space, often leads to defect accumulation and renders the leaky, undermining their potential biomedical applications. Herein we report using an emulsion-solution crystallization method control of BCP, poly ( l -lactide acid)- b -poly (ethylene glycol) (PLLA- -PEG), at The resultant BCP...
In recent decades, extensive studies have been devoted to assembling nanoparticles (NPs) into various ordered structures achieve novel optical properties. However, it still remains a challenging task assemble NPs cyclic one-dimensional (1D) shapes, such as rings and frames. Herein, we report directed assembly method precisely well-defined, free-standing frames using polymer single crystals (PSCs) the template. Preformed poly(ethylene oxide) (PEO) were used template direct crystallization of...
Responsive shape changes in soft materials have attracted significant attention recent years. Despite extensive studies, it is still challenging to prepare nanoscale assemblies with responsive behaviors. Herein we report on the fabrication and pH-responsive properties of sub-5 nm thin, Janus polymer nanoplates prepared via crystallization-driven self-assembly poly(ε-caprolactone)-b-poly(acrylic acid) (PCL-b-PAA) followed by cross-linking disassembly. The resultant nanoplate comprised...
Abstract One of the fundamental laws in crystallization is translational symmetry, which accounts for profound shapes observed natural mineral crystals and snowflakes. Herein, we report on spontaneous formation spherical hollow with broken symmetry crystalline molecular bottlebrush (mBB) polymers. The unique structure named as mBB crystalsome (mBBC), highlighting its similarity to classical vesicles. Fluorescence resonance energy transfer (FRET) experiments show that mBBC driven by local...
Inspired by stimuli-triggered unraveling of the von Willebrand factor from a nonsticky globular to stretched linear shape with exposure functional groups in blood clotting, this article reports on synthesis thermosensitive binary heterografted molecular brushes that exhibit temperature-induced changing between extended wormlike and collapsed yet stable conformations water. The are composed two distinct side chain polymers: poly(ethoxydi(ethylene glycol) acrylate) (PDEGEA), which undergoes...
ABSTRACT Janus hairy nanoparticles (JHNPs) represent a new class of hybrid materials with nanoparticle core and layer bicompartmentalized polymer brushes. This unique structure combines the complex properties brushes, amphiphilic nature surfactant, mechanical, optical, electronic nanoparticles. Over past decade, tremendous efforts have been devoted to synthesizing JHNPs understanding their properties. In this review, we will summarize recent progresses in field, including fabrication...
BST-2 (tetherin, CD317, and HM1.24) is induced by interferon restricts virus release tethering the enveloped viruses to cell surface. The effect of on influenza A (IAV) infection has been inconclusive. In present study, we report that diminishes production IAV virus-like particles (VLPs) are generated viral neuraminidase hemagglutinin proteins a much greater degree than it inhibits wild-type particles. This relatively weaker inhibition associated with reduction in levels, which caused M2...
Abstract Gradient polymer brushes provide a spatial gradient change in molecular characteristics of the brush, and such can be utilized to study structure–property relationships combinatorial fashion. In this study, bottom‐up method was used synthesize with predesigned precisely controlled grafting density brush pattern. A single‐crystal assisted grafting‐to (PSCAGT) employed where end‐functionalized polymers were grown into two‐dimensional single crystals. The latter chemically coupled...
A cucurbit[7]uril-based host-guest strategy is employed to enhance the efficiency of photolysis reactions that release caged molecules from photoremovable protecting groups. The benzyl acetate follows a heterolytic bond cleavage mechanism, thereby leading formation contact ion pair as key reactive intermediate. Gibbs free energy lowered by 3.06 kcal/mol through stabilization cucurbit[7]uril, revealed DFT calculations, which results in 40-fold increase quantum yield reaction. This methodology...
The transmission through contacts among MSM (men who have sex with men) is one of the dominating contributors to HIV prevalence in industrialized countries. In Amsterdam, capital Netherlands, risk group has been traced for decades. This motivated studies which provide detailed information about MSM's behavior statistically, psychologically and sociologically. Despite era potent antiretroviral therapy, incidence increases. long term contradictory effects effective therapy are still poorly...
SERINC5 is a multi-span transmembrane protein that incorporated into HIV-1 particles in producing cells and inhibits entry. Multiple retroviruses like HIV-1, equine infectious anemia virus murine leukemia are subject to inhibition, while pseudotyped with envelope glycoproteins of vesicular stomatitis Ebola resistant SERINC5. The antiviral spectrum the underlying mechanisms restriction not completely understood. Here we show influenza A infection by targeting virus-cell membrane fusion at an...
Open AccessCCS ChemistryCOMMUNICATIONS22 Dec 2022A Cleavable Self-Inclusion Conjugate with Enhanced Biocompatibility and Antitumor Bioactivity Han Wu, Tian Xia, Feilong Qi, Shan Mei, Yu Jiang-Fei Xu Xi Zhang Wu Key Laboratory of Organic Optoelectronics Molecular Engineering, Department Chemistry, Tsinghua University, Beijing 100084 , Xia MOE Bioorganic Phosphorus Chemistry Chemical Biology, Qi Mei *Corresponding author: E-mail Address: [email protected]...