A5100382619- Proteoglycans and glycosaminoglycans research
- Gallbladder and Bile Duct Disorders
- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Urological Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Urology and Nephrology Studies
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Advanced Fluorescence Microscopy Techniques
- Biliary and Gastrointestinal Fistulas
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Cell Image Analysis Techniques
- Gastrointestinal disorders and treatments
- Multiple and Secondary Primary Cancers
First Affiliated Hospital of Wannan Medical College
2012-2025
Wannan Medical College
2012-2025
Nanchang University
2024
Second Affiliated Hospital of Nanchang University
2024
Anhui Medical University
2024
Longyan University
2022-2024
Zhejiang Lab
2023
Third Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Air Force Medical University
2011-2022
Objectives To analyse the predictive factors for worse pathological outcome (muscle invasive pT2 +, non‐organ‐confined pT3 + or N and histological G rade 3) of upper tract urothelial carcinoma ( UTUC ) in a C hinese population from nationwide high‐volume centre hina. Patients Methods Predictors were studied by retrospectively reviewing clinicopathological data 729 consecutive patients with treated our J anuary 2002 to D ecember 2010. Univariate multivariate logistic regression analyses used....
Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system, influenced by various factors. Due to its subtle clinical symptoms, it delayed results in poor prognosis and limited treatment options. Cellular senescence, characterized stable growth arrest, closely linked proliferation inhibition, making promising therapeutic strategy for HCC. However, role Dual Specificity Phosphatase 3 (DUSP3) HCC-induced senescence underlying mechanisms remain poorly understood. Our...
It is unclear whether laparoscopic hepatectomy for hepatolithiasis patients with a history of biliary surgery achieves favorable clinical outcomes. This study aimed to evaluate the safety and feasibility reoperative (rLH). Patients who underwent anatomical liver resection between 2015 2022 were included in study. The outcomes rLH compared those open (rOH) initial (iLH). To ensure balanced baseline characteristics, propensity score matching was performed. A total 311 undergoing combined...
To summarize the experience of diagnosis and treatment congenital choledochal cyst in past 20 years (1980-2000).The clinical data 108 patients admitted from 1980 to 2000 were analyzed retrospectively.Abdominal pain,jaundice abdominal mass presented most child cases. Clinical symptoms adult cases non-specific, resulting delayed frequently. Fifty-seven (52.7%) had coexistent pancreatiobiliary disease. Carcinoma biliary duct occurred 18 (16.6%). Ultrasonic examination was undertaken 94 cases,...
The prevalence of infectious diseases is increasing in developing countries, and this may threaten the biological safety donated blood. This study analyzed trends transfusion-transmissible pathogens among Chinese, first-time, voluntary blood donors from 1999 to 2009 evaluate potential for disease transmission.From 2009, all first-time at Xi'an Blood Service (XBS) were screened hepatitis B virus (HBV), C (HCV), human immunodeficiency (HIV), syphilis infections using enzyme-linked...
Abstract Renal cell carcinoma (RCC) is characterized by substantial vasculatures and increased fluid movement in tumor microenvironment, the shear stress modulates malignance, extravasation metastatic seeding of cells. However, precise mechanism remains largely unclear. In this study, we found that low induced Yes-associated protein (YAP1) activation nuclear localization RCC cells, as well downregulation phosphorylated YAP1 at Ser127. Moreover, inhibition ROCK or RhoA partially abolished...
Background: It is unclear whether laparoscopic hepatectomy (LH) for hepatolithiasis confers better clinical benefit and lower hospital costs than open (OH). This study aim to evaluate the economic value of LH versus OH. Methods: Patients undergoing OH or primary at Yijishan Hospital Wannan Medical College between 2015 2022 were divided into group group. Propensity score matching (PSM) was used balance baseline data. Deviation-based cost modelling weighted average median (WAMC) assess compare...
Abstract Heparanase (HPSE) is a kind of multifunctional extracellular hydrolase, and related to metastasis hepatocellular carcinoma (HCC). Endothelial necroptosis promotes the cancer cells. It not clear whether HPSE could mediate microvascular endothelial cells (MVECs) promote HCC metastasis. Here we found expression was up-regulated in tissues its over-expression correlated with multiple tumor foci, invasion, poor outcome patients. Non-contact co-culture experiments showed high-expressed...
Objectives: Cancer stem cells (CSCs) comprise a small population of in cancerous tumors and play critical role tumor resistance to chemotherapy. miRNAs have been reported enhance the sensitivity pancreatic cancer However, underlying molecular mechanism requires better understanding. Methods: Cell viability proliferation were examined with CCK8 assays. Quantitative real-time polymerase chain reaction was executed assess mRNA expression. StarBase database used select target genes miRNA, which...
Breast cancer is the most commonly diagnosed neoplasm in women worldwide. New molecular biomarkers and effective prognostic models are being developed. This study aimed to investigate clinical significance of NUAK2 expression patients with breast cancer.The NUAK 2 was examined cells tissues by real-time PCR, western blotting, immunohistochemical staining. CCK-8 colony formation assays were performed verify effect on proliferation tumor progression cells. A assay nude mice analyze...
AIM:To summarize systematically our ten-year experience in non-surgical treatment of postoperative bile leakage, and explore its methods indications. METHODS:The clinical data 57 patients with leakage treated non-surgically from January 1991 to December 2000 were reviewed retrospectively. RESULTS:The site the was mainly disrupted or damaged fistulous tracts T tube 25 (43.9 %), fossae gallbladder 14 cases (24.6 %) , cut surface liver 7 cases(12.3%), it undetectable other 2 cases.Besides wrong...
The overall outcome of patients with hepatocellular carcinoma (HCC) is still very poor due to its high metastasis and recurrence rate. During metastasis, trans-endothelial migration (TEM) HCC cells a key step. Heparanase (HPSE) an endo-beta-glucuronidase exerts prometastatic properties for normal tumor-derived cells. However, it remains unclear that HPSE contributes TEM In this study, human umbilical vein endothelial cells-C (HUVEC-C) was used simulate vascular (VECs), the HCCLM3 expression...
The expression of heparanase (HPSE) was associated with postoperative metastatic recurrence in patients hepatocellular carcinoma (HCC). six E-box binding sites the core promoter HPSE gene suggested that transcription factors such as upstream stimulatory factor (USF) might regulate gene. aim our study is to measure levels and USF investigate relationship between clinicopathological parameters HCC. HPSE, USF1 USF2 expressions human HCC cell lines (BEL-7402, HepG2 HCCLM3) 15 fresh tissue...
A deep learning-enhanced light-sheet microscopy add-on in conjunction with a microfluidic chip allows conventional 2D inverted microscope to implement video-rate 3D isotropic imaging of live biological specimens.
The purpose of this study is to elucidate the impact long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration.Sema4D expression in 73 pairs CRC tissues matched adjacent normal was measured by qRT-PCR western blot its association with pathological characteristics patients analyzed chi-square test. Also, MIR4435-2HG, miR-125b-5p Sema4D lines detected blot. Knockdown or overexpression were separately...
Intrapancreatic ductal pressure was similar in ESPJ and BPJ.However, EEPJ significantly higher than that BPJ (P < 0.05).All three functional parameters, the secretory volume, flow rate of pancreatic juice, bicarbonate concentration, were as compared to 0.05).However, parameters BPJ.Pancreatography performed after revealed dilation meandering main duct, anastomotic site exhibited a variable degree occlusion, even blockage.Pancreatography BPJ, however, showed normal patency.Histopathology...
Objective. Heparanase (HPSE) is high-expressed in most malignant tumors including hepatocellular carcinoma (HCC) and promotes cancer cell invasion migration. The aim of the study to explore whether HPSE enhances adhesion metastasis HCC cells. Methods . expressions human cells were measured with real-time RT-PCR Western blot analysis. Four recombinant miRNA vectors pcDNATM6.2-GW/EmGFP-miR-HPSE (pmiR-HPSE) transfected into HCCLM3 cell. expression was measured. invasion, migration, abilities...
To validate the predictive value of preoperative hydronephrosis (HN) with regard to clinicopathological outcome and prognosis in a large cohort upper tract urothelial carcinoma (UTUC) patients, retrospective analysis was conducted using data 520 consecutive patients treated between 2000 2010 at nationwide high-volume center China. Preoperative computed tomography or magnetic resonance imaging scans were evaluated for presence ipsilateral HN, associations HN pathological outcomes, patient...