A5044359461- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Science, Research, and Medicine
- Immune cells in cancer
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- RNA and protein synthesis mechanisms
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Microscopic Colitis
- RNA Research and Splicing
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Renal and related cancers
- Pluripotent Stem Cells Research
Shanghai Jiao Tong University
2022-2024
Ruijin Hospital
2023-2024
State Key Laboratory of Oncogene and Related Genes
2022-2024
Shanghai Chest Hospital
2023
Renji Hospital
2023
Abstract The tumor microenvironment (TME) represents a complex network in which cells communicate not only with each other but also stromal and immune cells. intercellular interactions the TME contribute to initiation, progression, metastasis, treatment outcome. Recent advances spatial transcriptomics (ST) have revolutionized molecular understanding of at level. A comprehensive interactive analysis resource specifically designed for characterizing could facilitate further using ST. In this...
Abstract Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed spatial...
Pituitary neuroendocrine tumors (PitNETs) are common gland neoplasms demonstrating distinctive transcription factors. Although the role of immune cells in PitNETs has been widely recognized, precise immunological environment and its control over tumor poorly understood. The heterogeneity, spatial distribution, clinical significance macrophages were analyzed using single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, transcriptomics, immunohistochemistry, multiplexed quantitative...
The formation of transcription regulatory complexes by the association Smad4 with Smad2 and Smad3 (Smad2/3) is crucial in canonical TGFβ pathway. Although central requirement as a common mediator emphasized regulating signaling, it not obligatory for all responses. role Smad2/3 independently remains understudied. Here, we introduce stepwise paradigm which regulate lineage priming differentiation mouse embryonic stem cells (mESCs) collaboration different effectors. During naïve-to-primed...
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<div>Abstract<p>Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed...
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<div>Abstract<p>Stromal cells are physiologically essential components of the tumor microenvironment (TME) that mediates development and therapeutic resistance. Development a logical unified system for stromal cell type identification characterization corresponding functional properties could help design antitumor strategies target cells. Here, we performed pan-cancer analysis 214,972 nonimmune using single-cell RNA sequencing from 258 patients across 16 cancer types analyzed...
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