A5061470624- Computational Drug Discovery Methods
- Peroxisome Proliferator-Activated Receptors
- Cancer Immunotherapy and Biomarkers
- Receptor Mechanisms and Signaling
- Colorectal Cancer Surgical Treatments
- PI3K/AKT/mTOR signaling in cancer
- Minimally Invasive Surgical Techniques
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Synthesis and biological activity
- Eicosanoids and Hypertension Pharmacology
- Flowering Plant Growth and Cultivation
- Advanced Nanomaterials in Catalysis
- CAR-T cell therapy research
- Biochemical and Molecular Research
- Inflammatory mediators and NSAID effects
- Catalytic Processes in Materials Science
- Lung Cancer Treatments and Mutations
- Plant Physiology and Cultivation Studies
- Electrocatalysts for Energy Conversion
- Nanoplatforms for cancer theranostics
- Neurofibromatosis and Schwannoma Cases
- Plant Gene Expression Analysis
- Surgical Simulation and Training
Ruijin Hospital
2022-2025
Shanghai Jiao Tong University
2022-2025
Central South University of Forestry and Technology
2025
Central South University
2025
Qilu Normal University
2025
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
Beijing Institute of Neurosurgery
2025
Tianjin Medical University
2017-2024
Robotic Technology (United States)
2023
Abstract Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables discovery of potential therapeutic targets. Here, we profile 54,103 cells from and adjacent tissues to characterize cellular composition elucidate origin regulation tumor-enriched cell types in CRC. We demonstrate that tumor-specific FAP + fibroblasts SPP1 macrophages were positively correlated 14 independent CRC cohorts...
Abstract Background Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite significant progress, existing PI3K inhibitors encounter various challenges such suboptimal bioavailability, potential off-target effects, restricted therapeutic indices, cancer-acquired resistance. Hence, novel that overcome some these needed. Here, we describe the characterization KTC1101, a pan-PI3K inhibitor...
Head and neck squamous cell carcinoma (HNSCC) is the most common head cancer highly aggressive heterogeneous. Targeted therapy still main treatment method used in clinic due to lower side effect personalized medication. In order discover novel effective drugs with low against HNSCC, we analyzed genes related found that PIK3CA was expressed tumor tissues often experienced mutations, leading excessive activation of phosphoinositide 3-kinase alpha (PI3Kα), promoting development HNSCC. The...
The Cu-HCF-HA@Pt nanoplatform cause apoptosis via its dual-enzyme activity, photothermal properties, and Fenton-like reaction, which generates hydroxyl radicals, exhausts intracellular glutathione to achieve the effect of synergistic treatment.
Introduction Colorectal cancer (CRC) is the second most lethal malignancy worldwide. Immune checkpoint inhibitors (ICIs) benefit only 15% of patients with mismatch repair-deficient/microsatellite instability (dMMR/MSI) CRC. The majority are not suitable due to insufficient immune infiltration. Cancer vaccines a potential approach for inducing tumor-specific immunity within solid tumor microenvironment.
The technological barriers and steep learning curve of single-incision laparoscopic surgery had kept it from further applications. A literature review reported that robotic technology could preserve its advantages while simplifying difficulties. This nonrandomized cohort pilot study aims to evaluate the feasibility safety assisted colorectal based on a novel surgical platform, SHURUI Endoscopic Surgical Robotic System (SR-ENS-600).This enrolled 7 patients with malignancy who underwent...
Abstract: This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three adenocarcinoma datasets (GSE43458, GSE10072, GSE50081), subjects of which included smokers nonsmokers, were downloaded screen differentially expressed feature between nonsmokers. Based on identified genes, we constructed protein–protein interaction (PPI) network optimized using closeness centrality (CC) algorithm. Then, support vector machine (SVM) classification model was...
PPARα and PPARγ have been the most widely studied Peroxisome proliferator-activated receptor (PPAR) subtypes due to their important roles in regulating glucose, lipids, cholesterol metabolism. By combining lowering serum triglyceride levels benefit of agonists (such as fibrates) with glycemic advantages TZD), dual PPAR approach can both improve metabolic effects minimize side caused by either agent alone, hence, has become a promising strategy for designing effective drugs against type-2...
The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such edema, weight gain, and heart failure. single selective agonism is main cause effects. multi-target cooperative PPARα/γ dual agonist development a hot topic medicinal chemistry field. Saroglitazar first approved agonist, available India for treatment diabetic dyslipidemia. It got rid these With aim finding more protent agonists, scaffold hopping was used to...
Peroxisome proliferator-activated receptors (PPARs) are considered important targets for the treatment of Type 2 diabetes (T2DM). To accelerate discovery PPAR α/γ dual agonists, comparative molecular field analysis (CoMFA) were performed PPARα and PPARγ, respectively. Based on alignment, highly predictive CoMFA model was obtained with a cross-validated q2 value 0.741 conventional r2 0.975 in non-cross-validated partial least-squares (PLS) analysis, while PPARγ better ability shown values...
Telmisartan, a bifunctional agent of blood pressure lowering and glycemia reduction, was previously reported to antagonize angiotensin II type 1 (AT1) receptor partially activate peroxisome proliferator-activated γ (PPARγ) simultaneously. Through the modification telmisartan, researchers designed obtained imidazo-\pyridine derivatives with IC50s 0.49~94.1 nM against AT1 EC50s 20~3640 towards PPARγ partial activation. For minutely inquiring interaction modes relevant analyzing...
The expression characteristics of non-coding RNA (ncRNA) in colon adenocarcinoma (COAD) are involved regulating various biological processes. To achieve these functions, ncRNA and a member the Argonaute protein family form an RNA-induced silencing complex (RISC). RISC is directed by ncRNA, especially microRNA (miRNA), to bind target complementary mRNAs regulate their interfering with mRNA cleavage, degradation, or translation. However, how identify potential miRNA biomarkers therapeutic...
aDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China, 200025 bShanghai Institute Digestive Sponsorships or competing interests that may be relevant to content are disclosed at the end this article. Published online ■ *Corresponding author. Address: Department 200025, China. E-mail address: [email protected] (R. Zhao). (X. Cheng). This is an open access article distributed under terms Creative Commons Attribution-Non Commercial-No...
Communicated by Ramaswamy H. Sarma