A5102840033- Cystic Fibrosis Research Advances
- Trace Elements in Health
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Muscle Physiology and Disorders
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Cancer Diagnosis and Treatment
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Cancer-related gene regulation
- HIV Research and Treatment
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Gastrointestinal motility and disorders
- Magnesium in Health and Disease
- Molecular Sensors and Ion Detection
Ben-Gurion University of the Negev
2012-2024
Institut de Pharmacologie et de Biologie Structurale
2023
Université de Toulouse
2023
The University of Texas Southwestern Medical Center
2021-2023
Southwestern Medical Center
2021
The Technological College of Beer Sheva
2021
Medical University of South Carolina
2021
SleepMed
2021
Pediatrics and Genetics
2019
Google (United States)
2016
Treatment with pancreatic enzymes fails to completely correct malabsorption and gastrointestinal symptoms in patients cystic fibrosis (CF). The aim of the present study was examine small intestine CF without overt evidence disease using capsule endoscopy (CE).Patients received agile patency and, depending on result that procedure, then underwent standard CE PillCam SB (Given Imaging, Yokneam, Israel). A stool specimen taken same day as for determination calprotectin level.Forty-two ages 10...
Abstract Background Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite significant progress, existing PI3K inhibitors encounter various challenges such suboptimal bioavailability, potential off-target effects, restricted therapeutic indices, cancer-acquired resistance. Hence, novel that overcome some these needed. Here, we describe the characterization KTC1101, a pan-PI3K inhibitor...
The intestinal epithelium is a renewable tissue that requires precise balance between proliferation and differentiation, an essential process for the formation of tightly sealed barrier. Zinc deficiency impairs integrity epithelial barrier associated with ulcerative diarrheal pathologies, but mechanisms underlying role Zn2+ are not well understood. Here, we determined colonocytic sensing receptor, ZnR/GPR39, in mediating Zn2+-dependent signaling regulating differentiation colonocytes....
AXL overexpression is a common resistance mechanism to anti-cancer therapies, including the BYL719 (Alpelisib) - p110α isoform specific inhibitor of phosphoinositide 3-kinase (PI3K) in esophagus and head neck squamous cell carcinoma (ESCC, HNSCC respectively). However, mechanisms underlying remain elusive. Here we demonstrated that AP-1 transcription factors, c-JUN c-FOS, regulate ESCC. The expression was correlated with both patients ESCC lines. Silencing c-FOS tumor cells downregulated...
Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known be mediated, in part, by stromal cells surrounding tumor cells; however, mechanisms underlying such a phenotype remain unclear. To identify of cetuximab unbiased manner, RNA-sequencing (RNA-seq) HNC patient-derived xenografts (PDXs) was performed. Comparing gene expression HNC-PDXs before after treatment with indicated that...
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize effect on tumor microenvironment (TME) MAPK-driven HNC, elucidate tumor-host interaction mechanisms facilitating immune escape treatment, apply rationale-based therapy combination immunotherapy inhibitor induce clearance. Methods Mouse syngeneic tumors...
Zinc enhances epithelial proliferation, protects the digestive layer and has profound antiulcerative antidiarrheal roles in colon. Despite clinical significance of this ion, mechanisms linking zinc to these cellular processes are poorly understood. We have previously identified an extracellular Zn2+ sensing G-protein coupled receptor (ZnR) that activates Ca2+ signaling colonocytes, but its molecular identity as well effects on colonocytes' survival remained elusive. Here, we show Zn2+, by...
Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as colitis, contributing to diarrhoea and perpetuating inflammation. We show that the zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 essential for recovery dextran sodium sulfate (DSS) ulcerative colitis model. Loss results increased susceptibility DSS-induced inflammation, owing low expression tight...
Abstract Genomic alterations (GA) in PIK3CA leads to the hyper-activation of phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway more than 20% ovarian cancer (OC) patients. Therefore, PI3K therapies are under clinical evaluation for this subset Evidently, trials testing efficacy isoform-specific inhibitors (PI3Ki), patients having a stable disease eventually relapse, as tumors become resistant treatment. Hence, there is an urgent need develop new therapeutic combinations improve...
NKp44 (NCR2) is a distinct member of natural cytotoxicity receptors (NCRs) family that can induce cytokine production and cytolytic activity in human NK cells. Heparan sulfate proteoglycans (HSPGs) are differentially expressed various normal cancerous tissues. HSPGs were reported to serve as ligands/co‐ligands for other NCRs. However, HSPG expression not restricted either group be found also Our current study reveals function modulated through interactions with on cells themselves ‐ cis...
An understanding of the mechanisms underlying acquired resistance to cetuximab is urgently needed improve efficacy in patients with head and neck squamous cell carcinoma (HNSCC). Here, we present a clinical observation that MET pathway activation constitutes mechanism patient HNSCC. Specifically, RNA sequencing mass spectrometry analysis cetuximab-sensitive (CetuxSen ) cetuximab-resistant (CetuxRes tumors indicated amplification overexpression CetuxRes tumor compared CetuxSen lesion....
Despite of remarkable progress made in the head and neck cancer (HNC) therapy, survival rate this metastatic disease remain low. Tailoring appropriate therapy to patients is a major challenge highlights unmet need have good preclinical model that will predict clinical response. Hence, we developed an accurate time efficient drug screening method tumor ex vivo analysis (TEVA) system, which can patient-specific responses. In study, generated six patient derived xenografts (PDXs) were utilized...
Abstract Starch‐based nanoparticles are highly utilized in the realm of drug delivery taking advantage their biocompatibility and biodegradability. Studies have Quaternized starch (Q‐starch) for small interfering RNA (siRNA) delivery, which quaternary amines enable interaction with negatively charged siRNA, resulting self‐assembly complexation. Although reports present numerous applications, demonstrated efficacy is nonetheless limited due to undiscovered cellular mechanistic delivery. In...
SummaryOuabain, which inhibits specifically membrane-bound ATPase activity, also the establishment of antiviral state induced by interferon. Once is established, ouabain in-effective. This inhibitory effect reversed adding Na/K ions to cells. On contrary, interferon production unaffected same concentrations ouabain. It interest that in such interferon-yielding cells, decreases state.
Over 50% of human papilloma positive head-and-neck cancer (HNCHPV+) patients harbor genomic-alterations in PIK3CA, leading to hyperactivation the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway. Nevertheless, despite PI3K pathway activation HNCHPV+ tumors, anti-tumor activities inhibitors are moderate, mostly due emergence resistance. Thus, for potent and long-term tumor management, drugs blocking resistance mechanisms should be combined with inhibitors. Here, we delineate...
Using the yeast two-hybrid system, we screened a human placenta cDNA library and identified two proteins that interacted with Tat protein of caprine arthritis encephalitis virus (CAEV): EGF-like repeats 1–6 extracellular domain Notch2 receptor epithelin/granulin growth factor precursor. This interaction was also confirmed in mammalian cells. vitro mutagenesis assays, showed each one three cysteine residues located within cysteine-rich CAEV is essential for binding to both protein. It thus...
A his-linked H2S locus of Salmonella typhimurium has been further defined by direct isolation mutants. Expression this in Escherichia coli demonstrated.
10575 Background: Cancer of unknown primary (CUP) constitutes 3%-5% all newly diagnosed cancer cases. It presents a major diagnostic challenge as knowing the tumor tissue origin (ToO) is crucial for choosing optimal treatment. MicroRNAs are family non-coding, regulatory RNA genes involved in development and differentiation that were shown to be carcinogenesis. MicroRNAs, highly stable clinical samples tissue-specific, serve ideal biomarkers diagnosis. Our first generation assay identifies...