A5100324723- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Luminescence Properties of Advanced Materials
- Reproductive System and Pregnancy
- Millimeter-Wave Propagation and Modeling
- Bacterial Infections and Vaccines
- Fluid Dynamics and Vibration Analysis
- T-cell and B-cell Immunology
- Immune cells in cancer
- Microfluidic and Capillary Electrophoresis Applications
- Microwave Engineering and Waveguides
- Inflammatory Bowel Disease
- Antenna Design and Analysis
- Immune Response and Inflammation
- Wind Energy Research and Development
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoplatforms for cancer theranostics
- Innovation Diffusion and Forecasting
- Systemic Lupus Erythematosus Research
- TGF-β signaling in diseases
- Outsourcing and Supply Chain Management
- Berberine and alkaloids research
- Nuclear materials and radiation effects
- Cancer-related Molecular Pathways
- Electrowetting and Microfluidic Technologies
Northwest Women's and Children's Hospital
2024
Shanghai Jiao Tong University
2003-2024
Yangtze University
2024
Huanggang Central Hospital
2024
Wenzhou Medical University
2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Baystate Medical Center
2019
Fudan University Shanghai Cancer Center
2013-2018
Peking University
2017
Peking University First Hospital
2017
Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to development and progression tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), PTEN (12%) are prevalent diverse Chinese breast cancer patients, with 60 novel identified. A high proportion tumors harbors multiple mutations, especially plus (9.0%). Next, develop a recombination-based mutation barcoding (ReMB) library for impactful conferring clonal advantage proliferation drug...
An efficient red phosphor based on the substitution of Mn4+ for Ti4+ in lattice Mg2TiO4 was prepared through a sol–gel route. The characterized by X-ray diffraction (XRD), electron paramagnetic resonance (EPR) and UV-vis spectroscopy luminescent properties samples with varying concentrations were investigated. photoluminescence Mg2TiO4:Mn4+ compared corresponding sample via solid-state reaction commercial CaAlSiN3:Eu2+. absorption fine structure (XAFS) investigation reveals oxidation state...
Abstract There has been little study of how the evolution chemoresistance in cancer affects other aspects disease pathogenesis. Here, we show that an important axis driven by cytidine deaminase (CDA) also acts to suppress cell-cycle progression regulating cyclin E–CDK2 signaling. We found CDA was regulated miR-484 a gemcitabine-resistant model breast cancer. Elevating expression reversed effects, thereby enhancing gemcitabine sensitivity, accelerating cell proliferation, and redistributing...
Purpose Breast cancer remains a major cause of death in women worldwide, and tumor metastasis is the leading breast patients after conventional treatment. Chronic inflammation often related to occurrence growth various malignancies. This study evaluated prognosis based on contributors innate immune response: myeloid differentiation primary response 88 (MyD88) Toll-like receptor 4 (TLR4). Methods We analyzed data from 205 invasive ductal carcinoma (IDC) who were treated at Department Surgery,...
To clarify the roles of a new aberrantly spliced transcript FAK that lacks exon 26 (denoted -26-exon FAK) in human breast cancers. Transcripts expressed 102 tumor tissues and 52 corresponding normal were analyzed by RT-PCR DNA sequencing, as well agarose gel electrophoresis. The cDNA was cloned MCF-10A cells, then kinase activity, cellular localization migration capability examined western blotting, immunofluorescent staining assays, respectively. expression levels blotting MCF-7 cells...
Breast cancer (BC) is prevalent worldwide malignant cancer. Improvements in timely and effective diagnosis prediction are needed. As reported, secreted DAND5 contributed to BC metastasis. We aim assess whether peripheral blood serum could determine BC-specific mortality.We used immunohistochemistry staining detect expression our tissue array including 250 samples. Angiogenesis assay xenograft mice model were examine the function progression. Serum concentration of was examined by ELISA 1730...
The paper advanced the theoretical procedures for quantitative design on selective stacking of zwitterions in full capillary sample matrix by a cathodic-direction moving reaction boundary (MRB) electrophoresis (CE) under control electroosmotic flow (EOF). With procedures, we conducted computations two test analytes L-histidine (His) and L-tryptophan (Trp) MRB created with 30 mM pH 3.0 formic acid-NaOH buffer 2-80 sodium formate. results revealed following three predictions. At first, cannot...
Rheumatoid arthritis (RA) is a systemic autoimmune disease that results in chronic and inflammatory disorder. Dynamic balance of helper T cells (Th) 1 17 regulatory (Treg) broken RA. Since there no cure for RA at present, it necessary to find truly effective convenient treatment. Several studies have intended induce ergotopic regulation treat diseases. This study was undertaken potential ergotope peptides investigate their effects treating the animal model underlying mechanisms. First, we...
The aim of this study is to determine whether the regulatory role T cell vaccination (TCV) through inhibition Th1/Th17/Tfh and production autoantibodies on collagen-induced arthritis (CIA). First, CIA mice were treated with TCV. After disease onset, incidence severity change in joint histopathology evaluated. Mice TCV-treated group showed less infiltration inflammatory cells sections. TCV decreased frequencies related cytokines. Reduction IL-21 may be associated both Tfh Th17, which further...
Inflammatory bowel disease (IBD) is an immune-mediated inflammation of the gastrointestinal tract that includes Crohn and ulcerative colitis (UC). Although IBD associated with elevated levels innate adaptive immunity, relationship between circulating immune cells remains largely unknown. Therefore, we conducted a bidirectional 2-sample Mendelian randomization (MR) study to determine their causal relationship. Genome-wide association summary statistics were extracted from publicly available...
Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint disorders with immunological pathogenesis. However, the causal relationships between circulating immune cells them remain largely unknown. Therefore, we conducted a bidirectional two-sample Mendelian randomization (MR) study to determine their relationship. Methods: Genome-wide association summary statistics were extracted from publicly available databases regarding cell phenotypes, RA, OA. MR analysis...
We examine a manufacturer's strategic decision to its supplier's potential technology infringement behavior within co-opetitive supply chain, where the supplier serves as both production partner and market competitor. Our study investigates four reactions for manufacturer when faced with possible infringement: no response, initiating patent litigation, entering cross-licensing contract, or establishing pure licensing agreement supplier. The possesses choice decide whether infringe on...
Micro base stations will play an important role in the future millimeter-wave mobile networks. This paper presents a new array design for micro stations. The is microstrip grid structure configured to radiate 45-degree polarized waves. It was implemented low-cost FR4 PCB technology and tested 28-GHz band. shown that with size of 20×20×0.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> achieved wide bandwidth more than 28% high gain...