A5111717909- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Advanced Text Analysis Techniques
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Pharmacology and Obesity Treatment
- Catalytic Alkyne Reactions
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Catalytic C–H Functionalization Methods
- Heart Rate Variability and Autonomic Control
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Protein Degradation and Inhibitors
- Oxidative Organic Chemistry Reactions
Institute of Science Tokyo
2025
Nanjing Medical University
2024
National Health and Family Planning Commission
2024
National Clinical Research
2024
Shanghai Jiao Tong University
2024
Jingzhou Central Hospital
2012
BackgroundEffective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.MethodsWe enrolled 50 years of age or older diabetes, elevated blood pressure, and an increased risk cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a pressure less than 120 mm Hg standard 140 up 5 years. The primary outcome was composite nonfatal stroke, myocardial infarction, hospitalization...
Substantial heterogeneity in molecular features, patient prognoses, and therapeutic responses head neck squamous cell carcinomas (HNSCC) highlights the urgent need to develop classifications that reliably accurately reflect tumor behavior inform personalized therapy. Here, we leveraged similarity network fusion bioinformatics approach jointly analyze multiomics datasets spanning copy number variations, somatic mutations, DNA methylation, transcriptomic profiling derived a prognostic...
<div>Abstract<p>Substantial heterogeneity in molecular features, patient prognoses, and therapeutic responses head neck squamous cell carcinomas (HNSCC) highlights the urgent need to develop classifications that reliably accurately reflect tumor behavior inform personalized therapy. Here, we leveraged similarity network fusion bioinformatics approach jointly analyze multiomics datasets spanning copy number variations, somatic mutations, DNA methylation, transcriptomic profiling...
<p>Supplementary Tables</p>
<p>Supplementary Figures and legends</p>
<div>Abstract<p>Substantial heterogeneity in molecular features, patient prognoses, and therapeutic responses head neck squamous cell carcinomas (HNSCC) highlights the urgent need to develop classifications that reliably accurately reflect tumor behavior inform personalized therapy. Here, we leveraged similarity network fusion bioinformatics approach jointly analyze multiomics datasets spanning copy number variations, somatic mutations, DNA methylation, transcriptomic profiling...
<p>Supplementary Tables</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary Figures and legends</p>
Enynols are useful precursors for the synthesis of various carbon frameworks, like furanes, cyclopentenones, oxetanes and allenes. Thus, a simple way their preparation is significant interest. Here, authors reported straightforward protocol 1-en-4-yn-3-ols 2-en-4-yn-1-ols starting from two acetylenes one molecule an aldehyde. Depending on workup, different types products can be obtained. Heterocyclic aldehydes successfully used in reaction.