A5089531087- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Mosquito-borne diseases and control
- Monoclonal and Polyclonal Antibodies Research
- Angiogenesis and VEGF in Cancer
- Vascular Malformations Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Ocular Infections and Treatments
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Ocular Oncology and Treatments
- Viral Infections and Vectors
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Disorders and Treatments
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Systemic Lupus Erythematosus Research
- Surgical Simulation and Training
Universidade Federal de São Paulo
2016-2025
Instituto da Visão
2014-2024
Instituto Paulista de Estudos e Pesquisas em Oftalmologia
2020-2024
Pontifícia Universidade Católica de São Paulo
2023
Irmandade da Santa Casa de Misericórdia de São Paulo
2015-2020
Universidade Paulista
2020
Roche (Switzerland)
2020
Bioanalytical Systems (United States)
2018
Johns Hopkins University
2000-2016
University of Buenos Aires
2016
The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and spread to other parts of the Americas. A recent increase prevalence microcephaly newborn infants vision-threatening findings these is likely associated with rapid ZIKV.To evaluate ocular presumed intrauterine ZIKV infection Salvador, Bahia, Brazil.Case series at a tertiary hospital. Twenty-nine (defined by cephalic circumference ≤32 cm) diagnosis congenital were recruited through an active...
<h3>Aims:</h3> The aim of this study was to report the development or progression tractional retinal detachment (TRD) after injection intravitreal bevacizumab (Avastin) used as an adjuvant vitrectomy for management severe proliferative diabetic retinopathy (PDR). <h3>Methods:</h3> clinical charts patients who experienced TRD 1.25 mg before PDR were reviewed. <h3>Results:</h3> Eleven eyes (patients) out 211 injections (5.2%) that developed had identified. All refractory panretinal...
<h3>Background</h3> Data comparing systemic exposure and vascular endothelial growth factor (VEGF) suppression of ranibizumab, bevacizumab aflibercept following intravitreal injection are lacking. <h3>Methods</h3> Fifty-six patients with wet age-related macular degeneration received ranibizumab (0.5 mg), (1.25 or (2.0 mg). Serum pharmacokinetics plasma free VEGF were evaluated after the first third injections. <h3>Results</h3> Following dose, to was 5-, 37-, 9-fold higher than whereas, 9-,...
In 2015, a twenty-fold increase in the prevalence of microcephaly Brazil was reported, and Ministry Health associated this abnormal with maternal-fetal Zika virus (ZIKV) transmission.We assessed ophthalmological findings ten mothers their infants that had been clinically diagnosed ZIKV-related presented ocular abnormalities, born from May to December 2015.Seven (70.0%) referred symptoms during pregnancy (malaise, rash arthralgia), which six (85.7%) were first trimester. At time exam, no...
Purpose: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic edema (DME), or retinal vein occlusion (RVO). Methods: Prospective, open-label, nonrandomized clinical trial AMD, DME, RVO who were antivascular endothelial growth factor (VEGF) naïve had not received anti-VEGF for ≥4 months. Patients 3 monthly intravitreal injections aflibercept 2.0 mg, bevacizumab 1.25 (0.5 mg...
To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised nude rats. Cells were transplanted as a suspension (CS) or polarized monolayer plated on parylene membrane (PM).Sixty-nine rats (38 male, 31 female) surgically implanted with CS (n = 33) PM 36). Cohort subsets killed at 1, 6, 12 months after surgery. Both ocular tissues systemic organs (brain, liver, kidneys, spleen, heart, lungs) fixed...
<h3>Importance</h3> The Zika virus (ZIKV) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy. <h3>Objective</h3> To assess identify possible risk factors for born with a presumed clinical diagnosis ZIKV intrauterine infection. <h3>Design, Setting, Participants</h3> We conducted cross-sectional study at the Altino Ventura Foundation Recife, Brazil, that included 40 Pernambuco state, between May December 2015. Toxoplasmosis, rubella,...
Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, association of early oversedation clinical has not been thoroughly evaluated. The aim this study was to assess sedation strategies critically ill adult patients under mechanical ventilation (MV). A secondary analysis a multicenter prospective cohort conducted 45 Brazilian ICUs, including requiring ventilatory support first 48 hours ICU admissions, performed. depth...
Abstract Background Postoperative endophthalmitis (PSE) is a severe ocular complication that can lead to irreversible vision loss or even globe atrophy. The Endophthalmitis Vitrectomy Study (EVS) historically guided PSE management but increasingly questioned due advances in pars plana vitrectomy (PPV) techniques and its narrow focus on cataract surgery. This study aimed compare PPV followed by intravitreal antibiotic injection at the end of surgery (PPV + IVAIES) with alone (IVAI) managing...
To evaluate the amount of reflux and degree pain with intravitreal injection (IVT) using 6 different types syringes/needles 5 techniques scleral incision, including 3 modifications a beveled incision.This was study conducted in 205 eyes patients. IVT bevacizumab for retinal pharmacotherapy needles incision. The severity subjectively evaluated (0-10) width subconjunctival bleb arising from vitreal reflux. Secondary outcomes were increase intraocular pressure complication rate.The straight...