A5102705620- Mosquito-borne diseases and control
- Retinal and Optic Conditions
- Viral Infections and Vectors
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Neonatal and fetal brain pathology
- Ocular Infections and Treatments
- Dengue and Mosquito Control Research
- Biological Activity of Diterpenoids and Biflavonoids
- Child Nutrition and Water Access
- Tryptophan and brain disorders
- Dialysis and Renal Disease Management
- Infectious Encephalopathies and Encephalitis
- Ocular Disorders and Treatments
- Bipolar Disorder and Treatment
- Natural Compound Pharmacology Studies
- COVID-19 Impact on Reproduction
- Bioactive Compounds and Antitumor Agents
- Schizophrenia research and treatment
- Ocular Diseases and Behçet’s Syndrome
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
Hospital São Rafael
2019-2022
Secretaria da Saúde
2019-2022
Associação Paulista de Medicina
2022
Universidade Federal de São Paulo
2016-2021
Universidade do Porto
2016-2020
Instituto da Visão
2016-2018
Complexo Hospitalar Universitário Professor Edgard Santos
2017-2018
GTx (United States)
2017
Universidade Federal da Bahia
2016
Fundação Oswaldo Cruz
2016
The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and spread to other parts of the Americas. A recent increase prevalence microcephaly newborn infants vision-threatening findings these is likely associated with rapid ZIKV.To evaluate ocular presumed intrauterine ZIKV infection Salvador, Bahia, Brazil.Case series at a tertiary hospital. Twenty-nine (defined by cephalic circumference ≤32 cm) diagnosis congenital were recruited through an active...
Ideas and Opinions17 May 2016Emergence of Congenital Zika Syndrome: Viewpoint From the Front LinesFederico Costa, PhD, Manoel Sarno, MD, Ricardo Khouri, Bruno de Paula Freitas, Isadora Siqueira, Guilherme S. Ribeiro, Hugo C. Gubio Campos, Luiz Alcântara, Mitermayer G. Reis, Scott Weaver, Nikos Vasilakis, Albert I. Ko, Antonio Raimundo Almeida, PhDFederico PhDFrom Centro Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Sáude; Instituto Saúde Coletiva Faculdade Medicina Bahia,...
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined serum antibody response to ZIKV other flaviviruses in Brazilian women giving birth 2015–2016 outbreak. Infected pregnancies with intermediate or higher enhancement titers were at increased give microcephalic infants compared those lower (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant...
A esquizofrenia é um transtorno mental grave e crônico que afeta o pensamento, a percepção comportamento dos indivíduos. Evidências indicam fatores socioeconômicos desempenham papel significativo no desenvolvimento na evolução da doença, tornando vulnerabilidade social elemento crucial ser investigado. Este estudo tem como objetivo revisar relação entre esquizofrenia, analisando os impactos das condições socioeconômicas incidência, curso clínico acesso ao tratamento. Para isso, foi realizada...
Background The prevalence of developmental alterations associated with in-utero Zika virus (ZIKV) exposure in children is not well understood. Furthermore, estimation the Population Attributable Fraction (PAF) attributed to ZIKV has been performed due lack population-based cohorts data on symptomatic and asymptomatic exposures an appropriate control group. aim this study was characterize neurodevelopmental outcomes at 11 32 months age intrauterine estimate PAF secondary exposure....
To describe the ocular findings of two infants with congenital Zika syndrome born in São Paulo state, Brazil, outside primary outbreak region.Two female were submitted to a complete screening for infectious diseases, as well examination, fundus photography, and optical coherence tomography retina. One was ultrasound.Both children showed positive serology virus, other diseases ruled out. On one newborn had extensive bilateral macular chorioretinal atrophy hyperpigmented borders associated...
Objective To describe the neurological and neurodevelopmental outcomes of children with Congenital Zika Syndrome (CZS) associated microcephaly beyond 2 years age. Method We followed CZS-associated in an outpatient clinic Salvador, Brazil. Neurological assessments were performed using Hammersmith Infant Examination (HINE) Bayley Scales Toddler Neurodevelopment (Bayley-III) respectively. Results Of 42 included, 19 male (45.2%); median (interquartile range) age at evaluation was 28 (25–32)...
Abstract A new series of thirty‐two enantiomerically pure derivatives xanthones ( 3 – 34 ) were synthesized for antitumor evaluation. Two carboxyxanthones 1 and 2 used as chemical substrates coupled with selected chiral building blocks 43 62 ), achieving yields enantiomeric excess (ee) values higher than 92 99 %, respectively. Carboxyxanthones synthesized, by a multi‐step synthetic pathway via diaryl ether intermediate (Ullman reaction), being compound described here the first time. The...
To describe the differences in clinical presentation and relative disease burden of congenital Zika syndrome (CZS)-associated microcephaly at 2 large hospitals Salvador, Brazil that serve patients different socioeconomic status (SES).