A5064730042- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Intracranial Aneurysms: Treatment and Complications
- Photoreceptor and optogenetics research
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Ocular Surface and Contact Lens
- Traumatic Ocular and Foreign Body Injuries
- Ophthalmology and Eye Disorders
- Corneal surgery and disorders
- Cerebrovascular and Carotid Artery Diseases
- Advanced Memory and Neural Computing
- Head and Neck Surgical Oncology
- Toxoplasma gondii Research Studies
- Bacterial Infections and Vaccines
- Dermatological and Skeletal Disorders
- CCD and CMOS Imaging Sensors
Fondation Ophtalmologique Adolphe de Rothschild
2013-2024
Fondation de Rothschild
2011-2024
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
1987-2024
Institut de la Vision
2022
Fondation OCP
2013
Délégation Paris 6
2005-2009
Sorbonne Université
2006
Pitié-Salpêtrière Hospital
2006
Centre Hospitalier Intercommunal André Grégoire Montreuil
1999-2001
Réseau pour la Transition Énergétique
2000
Loss of photoreceptors in atrophic age-related macular degeneration results severe visual impairment, although some peripheral vision is retained. To restore central without compromising the residual field, we developed a wireless photovoltaic retinal implant (PRIMA; Pixium Vision, Paris, France) which pixels convert images projected from video glasses using near-infrared light into electric current to stimulate nearby inner neurons.We carried out first-in-human clinical trial test safety...
Loss of photoreceptors in atrophic age-related macular degeneration (AMD) results severe visual impairment. Since the low-resolution peripheral vision is retained such conditions, restoration central should not jeopardize surrounding healthy retina and allow for simultaneous use natural prosthetic sight. This interim report, prespecified study protocol, presents first clinical with a photovoltaic substitute providing AMD. In this open-label single group feasibility trial (NCT03333954,...
To assess the efficacy and safety of PRIMA neurostimulation system with a subretinal microchip for improving visual acuity (VA) in patients geographic atrophy (GA) due to age-related macular degeneration (AMD) at 48-months postimplantation.
Objective. Subretinal prostheses electrically stimulate the residual inner retinal neurons to partially restore vision. We investigated changes in neurosensory macular structures and it is thickness associated with subretinal implantation geographic atrophy (GA) secondary age-related degeneration (AMD).Approach. Using optical coherence tomography, distance between electrodes nuclear layer (INL) as well alterations of layers were measured over time above near chip implanted within atrophic...
Purpose Peripheral exudative haemorrhagic chorioretinopathy (PEHCR) is a rare disorder that often misdiagnosed. The aim of this study was to better characterise PEHCR and assess treatment options. Material methods Retrospective multicentric chart review. Results Of 84 eyes (69 patients) with referred between 2005 2017, the most common referral diagnosis choroidal melanoma (41.3%). Bilateral involvement found in 21.7% cases. Haemorrhagic retinal pigment epithelium detachment peripheral lesion...
To assess anatomical and functional outcomes after switching from dexamethasone implant (DEXi) to fluocinolone acetonide (FAci) in 113 diabetic macular edema eyes, a multicentric retrospective observational study was conducted. Seventy-five eyes (73.5%) were switched 1−8 weeks their last DEXi. The mean best-corrected visual acuity improved 59.8 letters at month 4 remained stable during the follow-up. central thickness (CMT) significantly decreased follow-up, with minimum of 320.9 μm 3....
Background After idiopathic epiretinal membrane (iERM) removal, it is unclear whether the internal limiting (ILM) should be removed. The objective was to assess if active ILM peeling after iERM removal could induce microscotomas. Methods PEELING study a national randomised clinical trial. When no spontaneous occurred, patients were either or group. Groups compared at month 1 (M1), M6 and M12 visits in terms of microperimetry, best-corrected visual acuity (BCVA) optical coherence tomography...
Purpose To evaluate the surgical technique for subretinal implantation of two sizes PRIMA photovoltaic wireless microchip in animal models, and refine these procedures human trials. Methods Cats Macaca fascicularis primates with healthy retina underwent vitrectomy surgery were implanted at macula/central retina. The 1.5mm chip was initially studied feline eyes. implant (2mm,1.5mm sizes) arrays primates. Feasibility evaluated a newly-developed technique, complications adverse events recorded....
Abstract Purpose To report clinical outcomes of two different timings intravitreal dexamethasone (DEX) implant administration for prevention diabetic macular oedema (DME) worsening following cataract surgery. Methods This multicentre, retrospective study included patients with DME who received an DEX 1 month before surgery, ‘precataract DEX’ group, or at the time ‘concomitant treatments’ group. Inclusion criteria were a follow‐up ≥3 months and ophthalmological examination optical coherence...
Abstract Purpose To report visual and anatomical outcomes determine predictors of good acuity (VA) recovery after macula‐off rhegmatogenous retinal detachment (RD). Methods Prospective multicentre study including 115 eyes from patients successfully operated on for RD, with assessment VA spectral‐domain optical coherence tomography (SD‐OCT) macular images at 1, 3, 6 12 months surgery. Results Over the follow‐up period, significantly improved median [IQR] 62 [46; 72] ETDRS letters 1 month to...
Some complications of vitrectomy are related to adherence the vitreous body retina. We studied whether these could be decreased by injecting a proteolytic enzyme, tissue plasminogen activator (TPA), at beginning surgery aid separation from retina.Fifty-six patients receiving for proliferative diabetic retinopathy were divided into two groups in this prospective, randomized, double-blind study. Group I received 25 microg intravitreal TPA buffered salt solution (BSS) 15 minutes before...
Abstract Objective To assess the efficacy and safety of PRIMA subretinal neurostimulation system 48-months post-implantation for improving visual acuity (VA) in patients with geographic atrophy (GA) due to age-related macular degeneration (AMD) at post-implantation. Design First-in-human clinical trial prosthesis atrophic AMD, measuring best-corrected ETDRS VA (Clinicaltrials.gov NCT03333954 ). Subjects Five GA, no foveal light perception logMAR 1.3 1.7 their worse-seeing “study” eye....
Background: The visual outcome after central retinal artery occlusion (CRAO) is poor, but its relationship with early reperfusion (ER) poorly known. We evaluated the incidence of ER in acute CRAO or branch (BRAO), and association clinical outcome. Methods: In this prospective observational multicenter study, we included patients macula-involving BRAO presenting within 24 hours from symptom onset. was initial evaluation using indocyanine green angiography (ICGA). primary best-corrected acuity...