A5004500397- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Herpesvirus Infections and Treatments
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Pharmaceutical industry and healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Renal Diseases and Glomerulopathies
- Healthcare Policy and Management
- Toxin Mechanisms and Immunotoxins
- ATP Synthase and ATPases Research
- Artificial Intelligence in Healthcare and Education
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Telemedicine and Telehealth Implementation
- Multiple Sclerosis Research Studies
- Cerebrovascular and genetic disorders
- Food Allergy and Anaphylaxis Research
Illinois Retina Associates
2016-2025
Midwestern University
2024
University of Illinois Chicago
2004-2023
Augusta University
2023
Macula and Retina Institute
2022-2023
Alex's Lemonade Stand Foundation
2020
University of Chicago
2009-2010
Investigate real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD).
Importance Aflibercept, 8 mg, may have greater therapeutic benefits compared with aflibercept, 2 in patients neovascular age-related macular degeneration (nAMD), including potentially improved outcomes and decreased treatment burden. Objective To assess safety efficacy of nAMD. Design, Setting, Participants The CANDELA trial was a phase 2, randomized, single-masked, open-label, 44-week clinical conducted the US. Treatment-naive active subfoveal choroidal neovascularization secondary to nAMD...
We aim to compare the capabilities of Chat Generative Pre-Trained Transformer (ChatGPT)-3.5 and ChatGPT-4.0 (OpenAI, San Francisco, CA, USA) in addressing multiple-choice ophthalmic case challenges.Both models' accuracy was compared across different ophthalmology subspecialties using clinical cases provided by American Academy Ophthalmology (AAO) "Diagnosis This" questions. Additional analysis based on image content, question difficulty, character length responses, model's alignment with...
Contributors The following document and appendices represent the third edition of Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy. These guidelines were developed by Diabetic Retinopathy Telehealth Working Group. This working group consisted a large number subject matter experts in clinical applications telehealth ophthalmology. editorial committee Mark B. Horton, OD, MD, who served as chair Christopher J. Brady, MHS, Jerry Cavallerano, PhD, cochairs. writing committees...
To assess the long-term safety and efficacy of 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (Iluvien; Alimera Sciences, Inc) in patients with diabetic macular edema (DME).Three-year, phase 4, nonrandomized, open-label observational study.Patients DME who previously received corticosteroid treatment without a clinically significant rise intraocular pressure (IOP; all eyes, n = 202 eyes 159 patients; 36-month completion, 94 eyes).A prospective, study which FAc at baseline then...
To evaluate the impact of reduction in geographic atrophy (GA) lesion growth on visual acuity GATHER trials using categorical outcome measures. Randomized, double-masked, sham-controlled phase 3 trials. Aged ≥50 years with non-center point involving GA and best corrected (BCVA) 25-80 Early Treatment Diabetic Retinopathy Study (ETDRS) letters study eye. GATHER1 consisted 2 parts. In Part 1, 77 patients were randomized 1:1:1 to avacincaptad pegol (ACP) 1 mg, ACP sham. 2, 209 1:2:2 4 GATHER2,...
Despite the effectiveness of existing anti-vascular endothelial growth factor (VEGF) therapies, a need remains for further treatment options to improve response rates and/or reduce injection or monitoring frequency in patients with diabetic macular edema (DME).To evaluate efficacy and safety brolucizumab vs aflibercept dosed every 4 weeks participants DME.This 52-week, double-masked, phase 3 randomized clinical trial included treatment-naive adults who had previously received anti-VEGF...
To evaluate whether topical acrizanib (LHA510), a small-molecule vascular endothelial growth factor receptor inhibitor, could suppress the need for anti-vascular therapy over 12-week period in patients with neovascular age-related macular degeneration.A phase 2 multicenter randomized double-masked, vehicle-controlled proof-of-concept study.Trial includes n = 90 active choroidal neovascularization due to degeneration and under treatment. All received an intravitreal injection of ranibizumab...
AbstractPurpose. Nectin-1 belongs to the immunoglobulin superfamily, mediates cell-cell adhesion in cadherin-based adherens junctions, and acts as a receptor for herpes simplex virus (HSV). The goals of this study were (1) determine whether nectin-1 is expressed ocular tissue that an important target HSV infections (2) type 1 (HSV-1) infection affects expression eye. Methods. Expression HSV-1 protein was determined by immunohistochemical analysis tissues untreated BALB/c mice euthanized...
Anti-vascular endothelial growth factor (VEGF) intravitreal injections, a mainstay of treatment for many retinal diseases to optimize visual outcomes, have been included in prior authorization (PA) initiatives. However, if clinicians are extremely accurate their use anti-VEGF medications, such administrative burdens may need reconsideration.
Investigate retinal fluid changes via a novel deep-learning algorithm in real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD).
Nectin-1 is an adherens junction protein that serves as entry receptor for neurotropic herpes simplex virus (HSV). The expression of nectin-1 in the central nervous system (CNS) has not been well defined. Furthermore, it known whether HSV infection effect on brain. To better understand normal and HSV-infected brain, authors used immunohistochemistry to characterize brain tissue uninfected adult mice infected with HSV-1. In CNS untreated mock-infected mice, virtually all neurons, ependymal...
To evaluate treatment-related preferences among patients receiving intravitreal anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (nAMD) or diabetic edema (DME).We conducted a prospective survey of with nAMD DME treated at one three US-based retina clinics. Prior to development, small focus groups anti-VEGF-treated identified five "attributes" considered important those DME: vision outcomes, cost the insurance provider, patient, frequency...
To evaluate correlations between variability in central foveal thickness (CFT) and vision with ranibizumab a HARBOR post hoc analysis.Patients neovascular age-related macular degeneration (nAMD; N=1097) received monthly or as-needed (PRN) (0.5 2.0 mg) for 24 months. Fluctuation scores were used to assess CFT variability; every time increased then decreased (or vice versa), numeric value of the change was added score. Magnitude <50 µm considered clinically insignificant did not count towards...