Matthew Schu
A5042664663- Genetic Associations and Epidemiology
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Cancer Genomics and Diagnostics
- Skin and Cellular Biology Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Genomics and Rare Diseases
- Multiple Myeloma Research and Treatments
- Nutrition, Genetics, and Disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Radiomics and Machine Learning in Medical Imaging
- melanin and skin pigmentation
- Autoimmune Bullous Skin Diseases
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Evolution and Genetic Dynamics
- Protein Degradation and Inhibitors
- Biological Research and Disease Studies
- Protein Tyrosine Phosphatases
- Genetics and Neurodevelopmental Disorders
Boston University
2012-2024
RTI International
2018-2024
Boston Public Schools
2015-2024
Q2 Solutions (United States)
2016-2018
Takeda (United States)
2011-2015
Molina Center for Energy and the Environment
2014
Millennium Engineering and Integration (United States)
2011
William & Mary
2003
To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated recent genome-wide studies whites.We analyzed a set 2.5 million imputed markers to basis AD an American population.Five hundred thirteen well-characterized cases and 496 cognitively normal control subjects.Data were collected from multiple sites as part Multi-Institutional Research on Genetic Epidemiology (MIRAGE) Study Henry Ford Health System...
Abstract Background Less is known about the genetic basis of Alzheimer's disease (AD) in African Americans (AAs) than non‐Hispanic whites. Methods Whole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD‐related variants from WES assessed an discovery cohort 422 cases and 394 controls. Replication sought sample 1037 1869 controls Alzheimer Genetics Consortium (ADGC). Results Forty‐four single nucleotide polymorphisms (SNPs) passed filtering...
Abstract Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci. Typically, such an approach rarely results in the identification of functional implicating a defined gene disease process. We now performed transcriptome-wide study (TWAS) allowing prediction effects AMD-associated on expression. The TWAS was based genotypes 16,144 late-stage AMD cases and...
Development of drug responsive biomarkers from pre-clinical data is a critical step in discovery, as it enables patient stratification clinical trial design. Such translational can be validated early phases and utilized inclusion parameter later stage trials. Here we present study on building accurate selective sensitivity models for Erlotinib or Sorafenib vitro data, followed by validation individual corresponding treatment arms generated the BATTLE trial. A Partial Least Squares Regression...
ABSTRACT Genes influencing opioid use disorder (OUD) biology have been identified via genome-wide association studies (GWAS), gene expression, and network analyses. These discoveries provide opportunities to identifying existing compounds targeting these genes for drug repurposing studies. However, systematically integrating discovery results relevant available pharmacotherapies OUD is challenging. To address this, we’ve constructed a framework that leverages databases identify candidate...
Background: Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited genetic disorder characterized by recurrent and chronic open wounds with significant morbidity, impaired quality of life, early mortality. RDEB patients demonstrate reduction or structural alteration type VII collagen (C7) owing to mutations in the gene COL7A1 , main component anchoring fibrils (AF) necessary maintain epidermal-dermal cohesion. While over 700 alterations have been reported cause (DEB), which may be...
Rationale: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that could benefit adults with comprised pulmonary health.Objective: To investigate n-3 PUFA associations spirometric measures of function tests (PFTs) and determine underlying genetic susceptibility.Methods: Associations biomarkers (α-linolenic acid, eicosapentaenoic docosapentaenoic acid [DPA], docosahexaenoic [DHA]) were evaluated PFTs (FEV1, FVC, FEV1/FVC) in meta-analyses across seven cohorts...
Abstract Tumor mutational burden (TMB) is defined as the number of somatic mutations per Mb genome and used to represent accumulation over life tumor. Recent evidence has shown that high TMB scores are associated with improved response immune therapies across multiple indications. However, derivation this score not well characterized, nor universally performed laboratories. Here we describe our methodology for calculating TMB, which considers an estimation true germline mutations, efficacy...
Oscillating population data often exhibit cycle irregularities such as episodes of damped oscillation and abrupt changes phase. The prediction is interest in applications ranging from food production to wildlife management. We use concepts dynamical systems theory present a model-based method for quantifying the risk impending irregularity.
Much less is known about the genetic basis of Alzheimer's disease (AD) in African-Americans (AAs) than white non-Hispanics (WNH). To identify potentially functional AD-related variants AAs, we sequenced and analyzed exomes seven AA participants with AD from Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study. The 88,867 identified single nucleotide polymorphisms (SNPs) were filtered based novelty, sequencing quality, potential for functionality, gene-network...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease which involves multiple body systems (e.g., immune, nervous, digestive, circulatory) and research domains immunology, metabolomics, the gut microbiome, genomics, neurology). Despite several decades of research, there are no established ME/CFS biomarkers available to diagnose treat ME/CFS. Sharing data integrating findings across these essential advance understanding this complex by...