Mohammad Othman
A5028415813- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Disorders and Treatments
- Genetic Associations and Epidemiology
- RNA regulation and disease
- Systemic Lupus Erythematosus Research
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced biosensing and bioanalysis techniques
- Gene expression and cancer classification
- Liver Disease and Transplantation
- Lanthanide and Transition Metal Complexes
- Organ Transplantation Techniques and Outcomes
- Cell Image Analysis Techniques
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Genetic and Kidney Cyst Diseases
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Complement system in diseases
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
University of Michigan
2012-2024
Damascus University
2019-2020
Michigan United
2002-2019
Ann Arbor Center for Independent Living
2013
Centre National de la Recherche Scientifique
2008-2011
Institut Galien Paris-Saclay
2009-2011
Université Paris-Sud
2008-2011
Eye Center
2011
W.K. Kellogg Foundation
2002-2010
Dean McGee Eye Institute
1999
We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH ( P < 10 −75 ), ARMS2 −59 C2/CFB −20 C3 −9 CFI −6 ). compared our top findings with the Tufts/Massachusetts General Hospital study of advanced (821 cases, 1,709 controls) genotyped 30 promising markers additional individuals (up to 7,749 4,625 controls). With these data, we identified locus TIMP3 (overall = 1.1 × −11...
Genetic variants at chromosomes 1q31-32 and 10q26 are strongly associated with susceptibility to age-related macular degeneration (AMD), a common blinding disease of the elderly. We demonstrate, by evaluating 45 tag SNPs spanning HTRA1, PLEKHA1, predicted gene LOC387715/ARMS2, that rs10490924 SNP alone, or variant in strong linkage disequilibrium, can explain bulk association between chromosomal region AMD. A previously suggested causal SNP, rs11200638, other examined only indirectly...
To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings clinical phenotypes genetic mutations.Adaptive optics scanning laser ophthalmoscopy (AOSLO) of photoreceptors were obtained 16 eyes: five retinitis pigmentosa (RP), three cone-rod dystrophy (CRD), eight without disease. A quadratic model was used illustrate cone spacing as a function eccentricity. Cone at 1 degrees eccentricity compared...
This study reports the design of a novel theragnostic nanomedicine which combines (i) ability to target prodrug gemcitabine an experimental solid tumor under influence magnetic field with (ii) imaging targeted tumoral nodule. concept is based on inclusion magnetite nanocrystals into nanoparticles (NPs) constructed by self-assembling molecules squalenoyl (SQgem) bioconjugate. The nanocomposites are characterized unusually high drug loading, significant susceptibility, and low burst release....
Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved low-density cholesterol modulation. Potential interaction APOE sex, smoking status has been reported. We present pooled analysis (n = 21,160) demonstrating late APOε4 (odds ratio [OR] 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P...
To determine the proportion of male patients presenting simplex retinal degenerative disease (RD: retinitis pigmentosa [RP] or cone/cone-rod dystrophy [COD/CORD]) with mutations in X-linked degeneration genes RPGR and RP2.Simplex males were defined as no known affected family members. Patients excluded if they had a history parental consanguinity. Blood samples from total 214 diagnosis collected for genetic analysis. The screened RP2 by direct sequencing PCR-amplified genomic DNA.We...
Abstract Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy aortopathy. Here we report genome-wide association scan of 466 BAV cases 4,660 age, sex ethnicity-matched controls with replication in up to 1,326 8,103 controls. We identify noncoding variant 151 kb from the gene encoding cardiac-specific transcription factor, GATA4, near-significance p.Ser377Gly GATA4 . was interrupted by CRISPR-Cas9 induced pluripotent stem cells...
To investigate in vivo the retinal microstructure X-linked retinitis pigmentosa (XLRP) caused by RPGR mutations as a prelude to treatment initiatives for this common form of RP.Patients with RPGR-XLRP (n = 12; age range, 10-56 years) were studied optical coherence tomography (OCT) wide region central retina. Overall thickness and outer nuclear layer (ONL) inner parameters across horizontal vertical meridians analyzed compared.Retinal architecture all patients was abnormal. At fovea younger...
Nanosized contrast agents have great potential in magnetic resonance molecular imaging applications for clinical diagnosis. This study proposes new nanoparticles spontaneously formed under mild conditions and composed of a noncovalent adduct between gadolinium complex, polymer beta-cyclodextrin (pbetaCD: MW 1.5 x 10(6) g mol(-1)) dextran grafted with alkyl chains (MD). The formation this supramolecular nanoassembly is based upon "lock-and-key" recognition process which the hydrophobic MD...
Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes with relatively normal anatomy, high hyperopic refractive error, and frequent association angle closure glaucoma vision loss. The constitutes the extreme of hyperopia or farsightedness, common error that associated strabismus amblyopia in children. NNO1 was first mapped nanophthalmos locus. We used combined pooled exome sequencing strong linkage data large family to map this locus identify canonical...
Abstract Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci. Typically, such an approach rarely results in the identification of functional implicating a defined gene disease process. We now performed transcriptome-wide study (TWAS) allowing prediction effects AMD-associated on expression. The TWAS was based genotypes 16,144 late-stage AMD cases and...