A5018275556- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Fish Biology and Ecology Studies
- Fish biology, ecology, and behavior
- Lipid metabolism and disorders
- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Regulation of Appetite and Obesity
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Molecular Biology Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Genetics, Aging, and Longevity in Model Organisms
- Renin-Angiotensin System Studies
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Global Cancer Incidence and Screening
- Chronic Lymphocytic Leukemia Research
Exact Sciences (United States)
2021
Thrive
2020-2021
Université de Montréal
2021
Detection Limit (United States)
2020
Aintree University Hospital
2018
University of Liverpool
2018
Amgen (United States)
2007-2017
Foundation Medicine (United States)
2012-2017
Jacksonville University
2016
Wellcome Sanger Institute
2016
A real-time trial of a cancer blood test Cancers diagnosed early are often more responsive to treatment. Blood tests that detect molecular markers have successfully identified individuals already known the disease. Lennon et al. conducted an exploratory study closely reflects way in which such would be used future. They evaluated feasibility and safety incorporating multicancer into routine clinical care 10,000 women with no history cancer. Over 12-month period, detected 26 cancers different...
While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based more accurately particle concentrations according to class (LDL, HDL, VLDL) size (small, medium, large). The these sub-fractions may be related risk cardiovascular disease metabolic disorders. We performed a genome-wide association study 17 measures determined by NMR together with triglycerides, ApoA1, ApoB in 17,296 women from the Women's Genome Health Study...
To investigate whether EGF receptor (EGFR) pathway mutations predicted response to monotherapy with panitumumab, an anti-EGFR monoclonal antibody, in a randomized phase III study of metastatic colorectal cancer.Using massively parallel multigene sequencing, we analyzed 320 samples for 9 genes, sequence data from 288 (90%) samples.Mutation rates were: KRAS (45%), NRAS (5%), BRAF (7%), PIK3CA (9%), PTEN (6%), TP53 (60%), EGFR (1%), AKT1 (<1%), and CTNNB1 (2%). In the open-label extension, 22...
We have previously reported a linkage peak on 1q42 in Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from covering the three candidate genes TRAX, DISC1 and DISC2, using sample of 458 families ascertained for schizophrenia. Two-point haplotype association analysis revealed significant region interest within gene. A common (HEP3) was observed to be significantly under-transmitted affected individuals (P=0.0031). HEP3 represents two SNP...
Background— Recent trial data have challenged the hypothesis that cholesteryl ester transfer protein (CETP) and high-density lipoprotein cholesterol (HDL-C) causal roles in atherothrombosis. One method to evaluate this issue is examine whether polymorphisms CETP gene impact on HDL-C levels also future development of myocardial infarction. Methods Results— In a prospective cohort 18 245 initially healthy American women, we examined over 350 000 singe-nucleotide (SNPs) first identify loci...
The primary aim of the Women's Genome Health Study (WGHS) is to create a comprehensive, fully searchable genome-wide database >360 000 single nucleotide polymorphisms among at least 25 initially healthy American women participating in ongoing NIH-funded (WHS). These have already been followed over 12-year period for major incident health events including but not limited myocardial infarction, stroke, cancer, diabetes, osteoporosis, venous-thromboembolism, cognitive decline, and common visual...
A total of 896 individuals Ashkenazi Jewish descent were ascertained in Israel from 267 multiplex families, including 472 sib-pairs affected with type 2 diabetes. genome-wide scan average marker spacing 9.5 cM revealed five regions on four chromosomes (4q, 8q, 14q, and 20q) that exhibited nominal evidence for linkage (P &lt; 0.05). The highest observed nonparametric Z score was 2.41 (equivalent to a logarithm odds 1.26) at D4S1501. maximal signal, 2.05, chromosome 20 near D20S195,...
Background— Genome-wide genetic association analysis represents an opportunity for a comprehensive survey of the genes governing lipid metabolism, potentially revealing new insights or even therapeutic strategies cardiovascular disease and related metabolic disorders. Methods Results— We have performed large-scale, genome-wide among 6382 white women with replication in 2 cohorts 970 additional men associations between common single-nucleotide polymorphisms low-density lipoprotein...
Fibrinogen is a multifunctional circulating glycoprotein involved in wound healing, thrombosis, platelet aggregation, and inflammation, elevated levels predict vascular disease. Despite evidence of crucial biological function moderate heritability, comprehensive analysis the influence genetic variation on fibrinogen not available.To address this issue, we undertook genome-wide association study evaluating potential relationships between 337 343 single-nucleotide polymorphisms (SNPs) plasma...
As part of a biomarker discovery effort in peripheral blood, we acquired an immunological profile cell-surface markers from healthy control and untreated subjects with relapsing–remitting MS (RRMS). Fresh blood each subject was screened ex vivo using panel 50 fluorescently labelled monoclonal antibodies distributed amongst 56 pools four each. From these pools, derived consisting 1018 'features' for our analysis systematic gating strategy. These profiles were interrogated screening phase (23...
Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed to a previously unreported susceptibility locus on chromosome 18p11. This result improved stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching logarithm odds 3.82 (allele sharing 0.6654) at point between markers D18S976 D18S391 when the most obese 20% sample was analyzed. Several genes 18 have been suggested as metabolic disease candidates, but none these colocalize our...