The metabolic consequences of obesity are well-documented in Western populations. However, limited data available on the association between body mass index (BMI) and cardiovascular risk factors developing countries. authors therefore examined BMI a very lean population China. A total 2,542 subjects aged 20–70 years from rural area Anqing, China, participated cross-sectional survey, 1,610 provided blood samples 1993. Mean (kg/m2) was 20.7 for men 20.9 women. After adjustment age, sex,...

Psoriasis is not only related to genetic factors but also environmental factors. However, the combined effect of and in development psoriasis has still been unclear.The study was analyze HLA-Cw6 smoking on vulgaris.A hospital-based case-control conducted study. One hundred seventy-eight cases 178 controls received this epidemiological investigation HLA typing by polymerase chain reaction utilizing sequence-specific primers.The risk smoking, adjusted odds ratio (OR) being 2.07 (P < 0.01),...

Cigarette smoking is the most established risk factor, and genetic variants and/or gene promoter methylations are also considered to play an essential role in development of lung cancer, but pathogenesis cancer still unclear. We collected data 150 cases age-matched sex-matched controls on a Hospital-Based Case-Control Study China. Face face interviews were conducted using standardized questionnaire. Gene polymorphism methylation status measured by RFLP-PCR MSP, respectively. Logistic...

Abstract As an important risk factor of respiratory disorders, traffic-related air pollution (TRAP) has caused extensive concerns. Epigenetic change been considered a link between TRAP and diseases. However, the exact effects on epigenetic changes are still unclear. Here we investigated dose- time- effect responses DNA methylations H3K9 acetylation (H3K9ac) in both blood lung tissues rats. The findings showed that every 1 μg/m 3 increase components were associated with %5 mC (95% CI) LINE -...

<title>Abstract</title> Background Coal miners are chronically exposed to underground air pollutants (e.g., coal dust, CO, NO₂), with a notably higher hypertension (HTN) incidence than the general population. Previous studies focused on single pollutants, yet health effects of occupational multipollutant mixtures remain unclear. This study aimed elucidate association between combined exposure and HTN, identifying dominant contributors. Methods Data were collected from 3,432 employed by three...

Abstract Urtica cannabina ( U . ), a member of the rticaceae family, is widely distributed throughout temperate regions world and can be used as nutritious feed for animals through winter period. To provide high‐quality forage all year‐round, we treated freshly harvested without additives (control), but with corn flour CF ) (5:1 w/w), molasses (2, 4, 8% fresh weight), or L alsi D ry LD inoculant (5, 10 20 mg kg −1 weight). We then assessed chemical composition, in vitro digestibility...

Dietary supplementation with Urtica cannabina is a viable source of available protein and fibre for livestock nutrition. To investigate the effect U. on gastrointestinal development growing animals, 32 male, 120-day-old Ujumuqin × small-tailed Han lambs were randomly assigned to one four dietary treatment groups: (1) G50 = 500 g/kg concentrate + mixed forage (control); (2) L50 Leymus chinensis; (3) U50 cannabina, or (4) L25-U25 250 L. chinensis cannabina. The treatments had similar energy...

Non–small cell lung cancer (NSCLC) is related to the genetic and epigenetic factors. The goal of this study was determine association cigarette smoking BPDE-DNA adducts with promoter methylations several genes in NSCLC. Methylation promoters p16, RARβ, DAPK, MGMT, TIMP-3 tumor tissues from 199 patients analyzed methylation-specific PCR (MSP), adduct level tissue obtained by ELISA. Level increased significantly males, aged people (over 60 years), smokers; however, no significant difference...

During the summer of 1999, information about respiratory health outcomes and relevant covariates was collected from 3,709 Chinese adults in Beijing, Anqing City, rural communities Prefecture. Indoor PM10 SO2 were measured a random sample selected households. Using logistic regression controlling for important (excluding SO2) familial intraclass correlation, highly significant differences found between study areas prevalences chronic cough, phlegm, wheeze, shortness breath, but not...

To investigate the effects of promoter methylation p16, death-associated protein kinase (DAPK) and retinoic acid receptor-beta (RAR beta) genes on clinical data in non-small cell lung cancers, to study effect smoking risk gene methylation.The DAPK RAR beta 200 primary cancers corresponding nonmalignant tissues were determined by methylation-specific PCR.Methylation tumor was detected 51.0% for 60.0% DAPK, 58.0% gene, with significant differences (P < 0.05) when compared those tissues(12.5%,...

Abstract Background Genetic factors were considered as one of the risk for lung cancer or other cancers. The aim this work was to determine whether a genetic predisposition accounts such familial aggregation among relatives probands. Methods A case-control study conducted in 800 case families identified by patients (probands), and control probands'spouses. data analysed with logistic regression analysis model. Results revealed significantly greater overall (OR = 1.82, P &lt; 0.01) proband...

To investigate the effect of CYP1A1 and GSTM1 genetic polymorphisms BPDE-DNA adducts on lung tumorigenesis.The case control study has included 200 cases cancer controls. DNA was extracted from blood samples all subjects. The genotype both were detected with PCR-based restriction fragment length (PCR-RELP). competitive ELISA.CYP1A1 mutant null smoke increased risk cancer, OR being 2.406(1.321-4.382), 2.755(1.470-5.163), respectively. level in patients greater than control, adduct ever smokers...

This study investigates the effects of restricted grazing time on forage selectivity and meat fatty acid deposition lambs compared to a traditional system. Results showed that animals preferred graze pasture species were more palatable lower in fibre, while demonstrating partial preference for with high protein levels. Leymus chinensis was preferentially selected by shorter periods than longer periods. Lambs grazed 4 h per day had LNA (α-linolenic acid) intake. The accumulation its...

Abstract Background Road traffic air pollution is linked with an increased risk of autistic spectrum disorder (ASD). The aim this study to assess the effect exposure prenatal or postnatal traffic-related combining concomitant noise on ASD-related epigenetic and behavioral alternations offspring. Methods A 2 × factorial analysis experiment was designed. Wistar rats were exposed at different sites (L group: green space; H crossroads) timings (E full gestation; P 21 days after birth) same time,...

&lt;i&gt;Background:&lt;/i&gt; The prevalence of allergic sensitization has increased all over the world during last years and may be related to genetic or environmental factors both. objective this study was estimate rates assess familial aggregation aeroallergens in asthma index families. &lt;i&gt;Methods:&lt;/i&gt; skin prick test (SPT) reactivity 8 SPT reactivity-related risk were evaluated. based on SPT. Univariate multivariate logistic regressive models used effect size (odds ratio,...