A5014166660- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Fungal and yeast genetics research
- Complement system in diseases
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Berberine and alkaloids research
- Immunotherapy and Immune Responses
- Thyroid Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Aquaculture Nutrition and Growth
- Cancer Immunotherapy and Biomarkers
- Medical Image Segmentation Techniques
- Pharmacology and Obesity Treatment
- Neural Networks and Applications
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Autoimmune Neurological Disorders and Treatments
Huazhong University of Science and Technology
2007-2025
Huazhong Agricultural University
2025
Hubei Provincial Water Resources and Hydropower Planning Survey and Design Institute
2025
Union Hospital
2022-2025
Tangshan Gongren Hospital
2024-2025
Guilin University of Electronic Technology
2025
Wuhan Union Hospital
2022-2024
Union Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2020-2024
Reduced insulin sensitivity is a key factor in the pathogenesis of type 2 diabetes and hypertension. Skeletal muscle resistance particularly important for its major role insulin-mediated glucose disposal. Angiotensin II (ANG II) integral regulating blood pressure plays In addition, we have documented that ANG II-induced skeletal associated with generation reactive oxygen species (ROS). However, linkage between ROS remains unclear. To explore potential mechanisms, employed transgenic...
Background . It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as new biomarker for diagnosis. However, the correlation between gastric cancer (GC) it is still unclear. Materials Methods In this study, by using real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs), we detected expression level hsa_circ_0001649 tissue serum samples from GC patients. Results We found was significantly downregulated compared...
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2)-expressing macrophages (TEMs) are an angiogenesis-promoting subset of tumor-associated that have been demonstrated to be increased in solid tumors associated the progression cervical cancer. However, induction mechanism TEMs remains unclear. Here, based on multicolor immunofluorescence 58 cancer tissues GEPIA database, we found were TIE2-high related shorter survival. In vitro vivo experiments verified...
Ovarian cancer (OC) is characterized by frequent widespread peritoneal metastasis. Cancer-associated fibroblasts (CAFs) represent a critical stromal component of metastatic niche and promote omentum metastasis in OC patients. However, the role exosomes derived from omental CAFs remains unclear. We isolated primary normal (NFs) patients (NF-Exo CAF-Exo, respectively) assessed their effect on In mice bearing orthotopic xenografts, CAF-Exo treatment led to more rapid intraperitoneal tumor...
Abstract Purpose Integrins are critical to cancer progression. Integrin alpha 5 (ITGA5) is correlated with the prognosis of cervical patients. However, whether ITGA5 plays an active role in progression or not remains unknown. Methods protein expression was detected 155 human tissues by immunohistochemistry. Data from The Cancer Genome Atlas were utilized identify risk factors for overall survival patients and ITGA5‐associated differentially expressed genes. Analyses single‐cell RNA‐seq based...
To investigate whether the use of mycophenolate mofetil (MMF) could reduce relapse risk in patients with myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG)-associated disorders (MOGADs).This prospective observational cohort study included MOGAD at Peking Union Medical College Hospital between January 1, 2017, and April 30, 2019. The were divided into 2 groups: those (MMF+) or without (MMF-) MMF therapy. primary outcome was follow-up. We used Cox proportional hazards models to...
Brucellosis is a major public health problem that seriously affects developing countries and could cause significant economic losses to the livestock industry great harm human health. Reasonable prediction of incidence significance in controlling brucellosis taking preventive measures.Our data were extracted from Shanxi Provincial Center for Disease Control Prevention. We used seasonal-trend decomposition using Loess (STL) monthplot analyse seasonal characteristics Province 2007 2017. The...
Background Observational studies have suggested an association between inflammatory markers and low back pain (LBP), but the causal relationship these factors remains uncertain. Methods We conducted a bidirectional two-sample Mendelian randomization analysis (MR) study to investigate whether there is pain. obtained genetic data for CRP, along with its upstream IL-6, IL-8, IL-10, as well from publicly available genome-wide (GWAS). applied several MR methods, including inverse variance...
Aim. We examined the methylation status of SNCA and FBN1 genes in patients’ paired tissue stool samples for detection colorectal cancer (CRC). Patients Methods . 89 DNA (normal/cancer) corresponding were analyzed our study. In addition, 30 collected as healthy controls. Results The level those was measured by methylation-specific polymerase chain reaction (MSP). result shows that compared with controls, both significantly hypermethylated CRC patients (<mml:math...
Abstract Malignant tumours of the appendix are quite rare, especially appendiceal adenocarcinomas, which may be difficult to detect preoperatively or intraoperatively. We collected data for 1404 patients with adenocarcinoma from Surveillance, Epidemiology, and End Results Program (SEER) database explore potential associations between clinicopathological factors overall survival. Furthermore, a novel nomogram predicting prognosis was developed based on our analysis SEER data. The prediction...
Colorectal cancer (CRC) is the third most commonly diagnosed and fourth leading cause of cancer‑related mortality worldwide. Thus, identification mechanisms involved in progression CRC has become a crucial element facilitating early diagnosis targeted therapy for patients with advanced CRC. Currently, Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), type histidine protein, been confirmed as tumor suppressor hepatocellular carcinoma (HCC) cervical cancer. However,...
Abstract The roles of phospholysine phosphohistidine inorganic pyrophosphate phosphatase ( LHPP ) in tumorigenesis have been recently proven hepatocellular carcinoma (HCC), cervical, pancreatic, bladder, and thyroid cancers. Previous research demonstrated that repressed cell proliferation growth by inactivating the phosphatidylinositol 3-kinase/ AKT signaling pathway vitro vivo. However, functions potential mechanisms as a tumor suppressor colorectal cancer (CRC) metastasis are still...
Abstract Background Omental metastasis is the major cause of ovarian cancer recurrence and shortens patient survival, which can be largely attributed to dynamic evolution fertile metastatic microenvironment driven by cells. Previously, we found that adipose-derived mesenchymal stem cells (ADSCs) undergoing a phenotype shift toward cancer-associated fibroblasts (CAFs) participated in orchestrated omental premetastatic niche for cancer. Here, aim elucidate underlying mechanisms. Methods Small...