A5032845373- Autoimmune and Inflammatory Disorders Research
- Bone Tissue Engineering Materials
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- Orthopaedic implants and arthroplasty
- Adolescent and Pediatric Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Rheumatoid Arthritis Research and Therapies
- Glutathione Transferases and Polymorphisms
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Macrophage Migration Inhibitory Factor
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Titanium Alloys Microstructure and Properties
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Immune cells in cancer
- Dental Trauma and Treatments
- Nutrition, Genetics, and Disease
Bashkir State Medical University
2014-2024
Russian Academy of Sciences
2007-2024
Institute of Chemical Biology and Fundamental Medicine
2024
Ministry of Health of the Russian Federation
2019-2022
Ufa State Aviation Technical University
2021
Institute of Geology Ufa Scientific Center
2014
Currently, significant attention is attracted to the problem of development specific architecture and composition surface layer in order control biocompatibility implants made titanium its alloys. The properties can be tuned both by creating an inorganic sublayer with desired morphology organic top coating contributing bioactivity. In this work, we developed a composite biologically active coatings based on hybrid molecules obtained chemical cross-linking amino acid bisphosphonates linear...
Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in metabolism fats glucose, as well contributes fatty degeneration myocardium heart failure development. may serve a risk factor biomarker for cardiovascular diseases, is also potential therapeutic target. The purpose this review was highlight current research data on EAT,...
Free radicals have taken a firm place among the explanatory principles of onset and development tumors. Unambiguous ideas about role these highly active agents in carcinogenesis not yet been obtained. The experimental results are contradictory, often opposite. field study value activity antioxidant systems based on obtained is no less controversial. In this regard, urgent problem need to prescribe antioxidants oncology. Antitumor effects being questioned many works, which brings forefront...
Titanium is considered to be the most essential metal in field of implantology. The main factors determining biocompatibility, among others, include morphology and chemical composition titanium surface. Therefore, aim this work was develop approaches control biological activity surface by creating coatings that combine both an inorganic phase with a given organic molecules containing integrin-selective peptide regulate cell adhesion proliferation. As such, we synthesized new c(RGDfC)...
Background . Prostate cancer (PCa) is the most common human worldwide. In progression of prostate cancer, total number macrophages in tumor tissue associated with poor prognosis and increased risk metastasis. However, heterogeneity intratumoral at various stages PCa development, role tumor-associated (TAMs) have been insuffciently investigated. The aim study was to analyze morphological features, size TAMs samples, reveal their correlation clinical data patients. Material Methods...
The article presents data on experimental study of the hepatoprotective activity pyrimidine derivatives (5-amino-6-methyluracil, 5-methylamino-6-methyluracil, 1,3,6-trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl N-phtalyl valinate, 5-piperidinomethyl-6-methyluracil, 3-morpholinomethyl-5-nitro-6-methyluracil) by incubation mouse hepatocytes МН-22а poisoned with carbon tetrachloride. MTT-test was used to determine cell viability. Positive control cells treated only tetrachloride (100 mM,...
MicroRNAs are key regulators of gene expression controlling components signaling cascades involved in the pathogenesis heart failure (HF). The profile microRNAs may serve as a sensitive indicator different types HF. aim present study was to compare miR-148b-3p, miR-30c-5p, miR-221-3p, miR-328-3p, miR-146a-5p, miR-375-3p, miR-22-3p, miR-15b-3p, miR-148a-3p, miR-590-5p peripheral blood mononuclear cells (PBMC) and epicardial adipose tissue coronary disease (СHD) patients with without HF...
Objective. Evaluation of ischemic kidney damage in hemorrhagic fever with renal syndrome severe severity using ultrasound techniques and urine gas analysis. Patients methods. Fifty patients at the Republican Clinical Infectious Diseases Hospital, Izhevsk, aged 40.5[33.0;46.0] years 2022–2023 a diagnosis HFRS 42 Ufa, 41.2[33.0;49.0] 2024 were examined. The syndrome, complications made accordance current clinical recommendations. Renal elastometry artery Dopplerography performed during febrile...
Objective ― The aim of the work was to study contribution immune response mediator genes polymorphism (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) formation predisposition juvenile idiopathic arthritis (JIA) and its clinical variants. Material Methods JIA group included 330 patients control – 342 volunteers without autoimmune diseases from...
The aim of the study was to analyze relationship immune response mediator genes’ polymorphic loci (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) variants with methotrexate efficacy in juvenile idiopathic arthritis (JIA).The included 274 JIA patients from Republic Bashkortostan, Russia. Achieving American College Rheumatology Pediatric 30 (ACR...
Abstract: The centrepiece of this analytical review is the metabolism hydroxyapatite in its natural, bone, and synthetic forms, where mitochondria-mediated mechanism may serve as leading mechanism. possibility that osteoblast mitochondria play an important role initial stages bone mineralisation discussed. Furthermore, paper highlights key hydroxyapatite.Differences between results vivo vitro studies using different morphologies are also detailed. It noted long-term infiltration with immune...
To date, descension of the pelvic floor is a fairly common gynecological pathology that requires surgical treatment. The development cellular technologies suggests use multipotent mesenchymal stem cells (MMSC) in treatment this can stimulate regeneration damaged tissue and contribute to reconstruction structures floor.to evaluate effectiveness using MMSC combination with biological synthetic materials vitro vivo floor.Sprague Dawley rats 10 weeks old weighing 200 grams were used experiment....
1 , Т.В.Викторова 2 О.Е.Мустафина Популяционный анализ полиморфного маркера rs1002149 гена глутатионредуктазы у жителей
Different cytokines are believed to play an important role in the pathogenesis of juvenile idiopathic arthritis (JIA). Some them may serve as prognostic markers for disease severity, eye lesion, and effectiveness therapy JIA patients. To evaluate serum concentration TNFα, IL1β, IL6 IL10, their spontaneous mitogen-induced production levels whole blood cell culture patients correlate these indicators with features methotrexate therapy. Twentyeight Russian JIA, naive disease-modifying...
Background . Melittin is a major constituent of honeybee venom and comprises water-soluble surfactant peptide with cytolytic effects potentially applicable in anticancer therapy. We evaluated the impact melittin from Bashkir ( Apis mellifera L.) on cell viability various prostate cancer lineages. Materials methods. MTT assays index estimation were used to evaluate effect proliferation various-grade malignancy (PC) lineages, LNCaP, PC-3 DU145. Results discussion. Lineage DU145 revealed low...