A5017979753- Pharmaceutical Economics and Policy
- Biotechnology and Related Fields
- Innovation Policy and R&D
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Intellectual Property and Patents
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Pharmacology and Obesity Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Hormonal Regulation and Hypertension
- Biosimilars and Bioanalytical Methods
- Science, Research, and Medicine
- Ovarian function and disorders
- Cardiac Arrhythmias and Treatments
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Diet and metabolism studies
- Electron Spin Resonance Studies
- Heart Rate Variability and Autonomic Control
- Growth Hormone and Insulin-like Growth Factors
- Statistical Methods in Clinical Trials
Novartis (Switzerland)
2016-2025
University of Zurich
2025
Hochschule Fresenius
2010-2024
National Patient Safety Foundation
2023
Center for Global Development
2023
Novartis (France)
2023
Novartis Institutes for BioMedical Research
2016-2022
University of Tübingen
2016
Bucheon St. Mary's Hospital
2016
Dongguk University Ilsan Hospital
2016
Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. Sacubitril/valsartan (LCZ696) was hypothesized increase natriuresis diuresis result in superior blood pressure control compared with valsartan Asian patients SSH. In this randomized, double-blind, crossover study, 72 SSH received sacubitril/valsartan 400 mg 320 once daily for 4 weeks each. diagnosed if the mean arterial increased ≥10% when switched from low (50...
Aims LCZ696 (angiotensin receptor neprilysin inhibitor) is a novel drug developed for the treatment of heart failure with reduced ejection fraction. Neprilysin one multiple enzymes degrading amyloid‐β (Aβ). Its inhibition may increase Aβ levels. The potential exists that LCZ696, through by LBQ657 (an metabolite), result in accumulation Aβ. aim this study was to assess blood–brain‐barrier penetration and effects on cerebrospinal fluid (CSF) concentrations isoforms healthy human volunteers....
Abstract Purpose To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant human fibroblast growth factor-21, for triglyceride lowering, weight loss, hepatic fat reduction. Methods A multicenter, double-blind, parallel design trial in obese, mildly hypertriglyceridemic adults randomized (1:1) to LLF580 300 mg or placebo subcutaneously every 4 weeks 3 doses. Results Of 64 study participants, 61 (mean ± SD: age 45 11 years, 49% male, 80/15/5% Caucasian/African...
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. The dual sodium-glucose co-transporter 1/2 inhibitor (SGLT1/2i) licogliflozin (LIK066) ameliorates hyperinsulinism in patients with diabetes obesity. This study examines the effect of on androgens women PCOS. In a multicentre, randomized, placebo-controlled, double-blind, 2-week trial, PCOS received 50 mg or placebo three times day (TID). Changes free testosterone (FT), other variables resistance...
Soil-dwelling Streptomyces bacteria such as S.coelicolor have to constantly adapt the nitrogen (N) availability in their habitat. Thus, strict transcriptional and post-translational control of N-assimilation is fundamental for survival this species. GlnR a global response regulator that controls transcription genes related S. coelicolor other members Actinomycetales. represents an atypical orphan not activated by phosphorylation conserved aspartate residue (Asp 50). We applied analysis,...
Previous analyses provide an industry benchmark of ∼10% for the success rate in clinical development. However, prior were limited by a narrow timeframe, diverse research focus, biases phase-to-phase transition methodology or focus on specific use cases. We calculated unbiased input:output ratios (Phase I to FDA new drug approval) analyze likelihood first approval using data from clinicaltrials.gov, encompassing total 2092 active ingredients, 19 927 trials conducted 18 leading pharmaceutical...
What is known and objective Sacubitril/valsartan (LCZ696) has been recently approved for the treatment of heart failure (HF) patients with reduced ejection fraction. Several HF receive statins as co-medication. Methods Because clearance meditated via OATP1B1/1B3, inhibition potential these transporters by LCZ696 analytes was evaluated in vitro. Furthermore, an open-label, fixed-sequence clinical study conducted to determine effect on exposure simvastatin its active metabolite acid. In this...
The aim of this study was to determine the role renal innervation in prolonged stimulation renin secretion and synthesis accompanying artery stenosis. Male Sprague-Dawley rats, which left kidney had been denervated or sham 4 days earlier, received a clip (ID 0.2 mm). Plasma activity mRNA were assayed 1, 2, after clipping. both plasma blunted markedly rats with clipped kidney. typical suppression intact right kidney, however, not different between sham-denervated kidneys, nor increase blood...
The pharmacokinetics of otamixaban was investigated in healthy male subjects over a wide range intravenous doses, with duration administration varying between 1‐minute infusions (bolus dose) and 24‐hour infusions, using noncompartmental multicompartmental methods. A global compartmental analysis (2 3 compartments) generated single set pharmacokinetic parameters, regardless infusion rate duration, took into account the 30% decrease clearance volume distribution observed dose range....
Cefditoren is a broad-spectrum, oral cephalosporin that highly active against clinically relevant respiratory tract pathogens, including multidrug-resistant Streptococcus pneumoniae. This study described its pharmacodynamic profile in plasma and epithelial lining fluid (ELF). Plasma ELF pharmacokinetic data were obtained from 24 patients under fasting conditions. urea concentrations determined bronchoalveolar lavage by liquid chromatography-tandem mass spectrometry. Concentration-time...
This study aimed to investigate and compare the effects of pharmacological T‐type calcium channel L‐type blockade on renin system. To this end, male healthy Sprague‐Dawley rats were treated with T‐channel blocker mibefradil or L‐channel amlodipine at doses 5 mg kg −1 , 15 45 per day for four days their plasma activity (PRA) kidney mRNA levels determined. Whilst lowered basal systolic blood pressure had no effect in whole dose range examined. Amlodipine dose‐dependently induced up 7 fold...