A5037505762- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Clinical Laboratory Practices and Quality Control
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Abdominal Surgery and Complications
- Respiratory Support and Mechanisms
- Cerebrospinal fluid and hydrocephalus
- Urinary Tract Infections Management
- Clinical practice guidelines implementation
- Spinal Fractures and Fixation Techniques
- Tracheal and airway disorders
- Renin-Angiotensin System Studies
- Trauma Management and Diagnosis
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Intensive Care Unit Cognitive Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University Hospital Regensburg
2014-2024
University of Regensburg
1998-2021
Universität Ulm
2006
In Europe, intravenous fosfomycin (IV) is used particularly in difficult-to-treat or complex infections, caused by both Gram-positive and Gram-negative pathogens including multidrug-resistant strains. Here, we investigated the efficacy safety of under real-life conditions.Prospective, multi-center, non-interventional study patients with bacterial infections from 20 intensive care units (ICU) Germany Austria (NCT01173575).Overall, 209 were included (77 females, 132 males, mean age: 59 ± 16...
The isolation of affected patients and intensified infection control measures are used to prevent nosocomial transmission vancomycin-resistant enterococci (VRE), but early detection VRE carriers is needed. However, there still no standard screening criteria for VRE, which poses a significant threat patient safety. Our study aimed develop evaluate an artificial intelligence (AI)-based approach identifying predicting at-risk who could assist prevention staff through human-in-the-loop approach....
Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects disease and refine treatment strategies but also improve clinical decision-making. For decision-making in particular, prognostic factors a lethal course would be highly relevant.
This study aimed to investigate and compare the effects of pharmacological T‐type calcium channel L‐type blockade on renin system. To this end, male healthy Sprague‐Dawley rats were treated with T‐channel blocker mibefradil or L‐channel amlodipine at doses 5 mg kg −1 , 15 45 per day for four days their plasma activity (PRA) kidney mRNA levels determined. Whilst lowered basal systolic blood pressure had no effect in whole dose range examined. Amlodipine dose‐dependently induced up 7 fold...
Abstract Background: Migration, production of reactive oxygen species (ROS), release myeloperoxidase (MPO), and NETosis are functional immunological reactions elementary importance for polymorphonuclear neutrophils (PMN). Unregulated inflammatory response PMN within tissues plays a key role in the pathophysiology several diseases. However, little is known about behavior after migration through blood vessel walls. Therefore, we investigated influence extracellular matrix (ECM) on function....
This study aimed to characterize the cellular pathways along which nitric oxide (NO) influences secretion of renin from kidney. Using isolated perfused rat kidney model, we found that NO donor sodium nitroprusside (SNP) (1–30 μmol/l) induced a prompt, concentration-dependent fourfold increase basal secretion. The membrane-permeable cGMP analogs 8-bromo-cGMP and 8-(4-chlorophenylthio)-cGMP (8-pCPT-cGMP; each 5–50 inhibited attenuated stimulation by SNP. Conversely, stimulatory effect SNP was...
Background Patients with COVID-19 and severe acute respiratory failure may require veno-venous extracorporeal membrane oxygenation (VV ECMO). Yet, this procedure is resource-intensive high mortality rates have been reported. Thus, predictors for identifying patients who will benefit from VV ECMO would be helpful. Methods This retrospective study included 129 failure, had received at the University Medical Center Regensburg, Germany, between 1 March 2020 31 December 2021. Patient-specific...
BACKGROUND Autologous platelet‐rich plasma (PRP) can be used either to prevent platelets (PLTs) from lesions during extracorporeal circulation or for wound therapy, when processed into PLT gel. The aim of this study was evaluate the sequestration abilities a new‐generation autotransfusion device. STUDY DESIGN AND METHODS In experimental discontinuous, device XTRA evaluated using fresh donor blood. blood in four different size bowls (X55, X125, X175, X225 [bowls' mL]) device's built‐in “PLT...
Background . Inadequate bowel movements might be associated with an increase in intracranial pressure neurosurgical patients. In this study we investigated the influence of a structured application laxatives and physical measures following strict standard operating procedure (SOP) on movement, (ICP), length hospital stay patients serious acute cerebral disorder. Methods After implementation SOP suffering from disorder received pharmacological nonpharmacological to improve standardized manner...
Background Various rescue techniques are used for the prehospital transport of trauma patients. This study compares different in terms immobilization cervical spine and time. Methods A wireless motion capture system (Xsens Technologies, Enschede, The Netherlands) was to record three-dimensional space time a standardized environment. Immobilization performed by applying through teams trained paramedics physicians. All tests were on set course, starting with test person lying floor ending an...
According to the literature, validity and reliability of medical documentation concerning episodes cardiopulmonary resuscitation (CPR) is suboptimal. However, little known about quality CPR efforts during intensive care unit (ICU) stays in electronic patient data management systems (PDMS). This study analyses CPR-related within ICU PDMS.In a retrospective chart analysis, PDMS records three ICUs single university hospital were searched over 5 y for check marks. Respective datasets analyzed...
Bei der Dokumentation eines Akutschmerzdienstes (ASD) entstehen große Datenmengen. Im klinischen Alltag spielen eine erleichterte Datenerhebung sowie verbesserte Dokumentationsqualität und Auswertbarkeit entscheidende Rolle. Die elektronische Patientenakte findet daher zunehmende Verbreitung. Bislang standen nur wenige kommerzielle Programme zur Verfügung, die auf Bedürfnisse zugeschnitten sind. Wir beschreiben Entwicklung Implementierung Software Schmerzvisite (Fa. Medlinq, Hamburg) in den...
Es wird von einer Patientin berichtet, bei der es nach schweren Subarachnoidalblutung zu kardialen Mitbeteiligung mit inversen Tako-Tsubo-Kardiomyopathie gekommen war. Um manifeste zerebrale Ischämien vermeiden, war ausgeprägten zerebralen Vasospasmen neben konservativen Therapieoptionen passager eine endovaskuäre Therapie mittels kontinuierlicher intraarterieller Applikation Nimodipin notwendig. Bei insgesamt sehr langwierigem und kompliziertem Verlauf waren die therapeutischen Bemühungen...
Abstract Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects this disease and refine treatment strategies but also improve clinical decision-making. For last aspect in particular, predictors a lethal course would be highly relevant. Methods: In retrospective cohort study, we analyzed first 59 adult Covid-19 treated one intensive care units University Medical Center Regensburg, Germany. Using uni- multivariable...