A5089434362- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Transplantation Techniques and Outcomes
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Simulation-Based Education in Healthcare
- Intraperitoneal and Appendiceal Malignancies
- Airway Management and Intubation Techniques
- Medical and Health Sciences Research
- Mechanical Circulatory Support Devices
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Appendicitis Diagnosis and Management
- Thermal Regulation in Medicine
- Drug-Induced Hepatotoxicity and Protection
- Organ Donation and Transplantation
- Biomedical and Chemical Research
- Liver Diseases and Immunity
- Abdominal Surgery and Complications
- Organ and Tissue Transplantation Research
Innsbruck Medical University
2022-2024
University Hospital Regensburg
2013-2022
University of Regensburg
2009-2018
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2015
University of Göttingen
2006-2010
Heidelberg University
1997-2008
University Hospital Heidelberg
2003-2008
Universitätsmedizin Göttingen
2007
Heidelberg University
2002-2005
Czech Academy of Sciences, Institute of Physiology
2005
Bupivacaine causes muscle damage. However, the myotoxic potency of ropivacaine is still unexplored. Therefore, we performed this study to compare effects bupivacaine and on skeletal tissue in equipotent concentrations. Femoral nerve catheters were inserted into anesthetized minipigs, 20 mL either (5 mg/mL) or (7.5 was injected. Subsequently, (2.5 (3.75 continuously infused over 6 h. Control animals treated with corresponding volumes normal saline. Finally, samples dissected at injection...
The role of venovenous extracorporeal membrane oxygenation (VV ECMO) in patients with COVID-19-induced acute respiratory distress syndrome (ARDS) still remains unclear. Our aim was to investigate the clinical course and outcome those identify factors associated need for prolonged ECMO therapy.A retrospective single-center study on VV COVID-19-associated ARDS performed. Baseline characteristics, ventilatory parameters, laboratory virological results were evaluated over time. Six months...
Compared with bupivacaine, acute myotoxicity of ropivacaine is less severe. Thus, in this study we compared the long term myotoxic effects both drugs a clinically relevant setting. Femoral nerve catheters were inserted anesthetized pigs, and either 20 mL bupivacaine (5 mg/mL) or (7.5 was injected. Subsequently, (2.5 (3.75 continuously infused (8 mL/h) over 6 h. Control animals treated corresponding volumes normal saline. After 7 28 days, respectively, muscle samples dissected at former...
Cardiac toxicity significantly correlates with the lipophilicity of local anesthetics (LAs). Recently, infusion lipid emulsions has been shown to be a promising approach treat LA-induced cardiac arrest. As postulated mechanism action, so-called "lipid sink" effect may depend on LAs. In this study, we investigated whether effects differ regard administered LAs.In isolated rat heart, arrest was induced by administration equipotent doses bupivacaine, ropivacaine, and mepivacaine, respectively,...
Background Bupivacaine produces skeletal muscle damage in clinical concentrations. It has been suggested that this may be caused by an increased intracellular level of [Ca2+]. Therefore, the aim study was to investigate direct effects bupivacaine on Ca2+ release from sarcoplasmic reticulum (SR), uptake into SR, and sensitivity contractile proteins. Methods Saponin skinned fibers extensor digitorum longus BALB/c mice were examined according a standardized procedure described previously. For...
In Brief BACKGROUND: the immature brain, neuronal Ca2+ oscillations are present during a time period of high plasticity and regulate differentiation synaptogenesis. this study we examined long-term blockade hippocampal oscillations, role N-methyl-D-aspartate (NMDA) receptors effects S(+)-ketamine on synapsin expression. METHODS: Hippocampal neurons were incubated at day 15 in culture with specific NMDA receptor antagonists dizocilpine (MK 801, 100 μM) or (3 μM to 25 for 24 hours....
We evaluated intermittent and continuous thermodilution cardiac output data in 12 patients undergoing orthotopic liver transplantation. Measurements were performed at 16 predefined time points between induction of anaesthesia 3 h after reperfusion the graft. Cardiac measurements yielded 192 pairs (intermittent range: 1.8–18.9 l.min −1 , 3.3–20.0 ). During most procedure correlation was significant ( r = 0.87, p < 0.0001), accompanied with a bias −0.240 degree precision 1.789 (< 10.0 :...
Background: Analysis of critical incidents in anaesthesia practice emphasizes the important role non‐technical skills (NTS) improving patient safety. Therefore, debriefing with regard to NTS has been added medical management (MM) simulator training improve acute crisis competencies anaesthesiologists. The purpose this study was compare and MM performance two groups anaesthesiologists a simulated after undergoing different types training. Methods: Forty‐two were randomly assigned groups, each...
Pump-driven extracorporeal membrane oxygenation (ECMO) or pumpless arterio-venous interventional lung assist (iLA) is associated with possible complications, mainly consisting of bleeding thrombosis/clotting by cellular deposits on the circuit surfaces, which may reduce gas-exchange capacity. In this study, we report our experiences addition low-dose acetylsalicylic acid (ASA 1.5 mg/kg body weight/d) to heparin for anticoagulation a low-resistance (Novalung GmbH, Talheim, Germany). We...
To investigate changes in intracellular Ca2+-regulation and Ca2+-sensitivity of the contractile apparatus murine skeletal muscle fibers during sepsis.Animal study a university-based research laboratory.Isolated (M. extensor digitorum longus) septic mice.In one group, sepsis was induced "black six" mice using cecal ligation puncture (CLP). In second laparotomy (SHAM), third general anesthesia (GA) performed. Saponin-skinned were examined 2, 3, 5, 7 days after treatment, caffeine-induced...
Abstract Introduction The current debate about the side effects of induction agents, e.g. possible adrenal suppression through etomidate, emphasizes relevance choosing correct agent in septic patients. However, cardiovascular depression is still most prominent adverse effect these and might be especially hazardous patients presenting with a biventricular cardiac dysfunction - or so-called cardiomyopathy. Therefore, we tested dose-response direct clinically available agents an isolated rat...
Increased intracellular Ca concentrations are considered to be a major pathomechanism in local anesthetic myotoxicity. Racemic bupivacaine and S-ropivacaine cause release from the sarcoplasmic reticulum of skeletal muscle fibers simultaneously inhibit reuptake. Examining optical isomers both agents, authors investigated stereoselective effects on muscular regulation get closer insight subcellular mechanisms myotoxicity.R- S-enantiomers as well racemic mixtures agents were tested 1, 5, 10, 15...
Summary Background: According to different algorithms of airway management, emergency cricothyrotomy is the final step in managing an otherwise not accessible airway. As alternative open surgical procedure, minimally invasive approaches exist. Quicktrach baby™ a commercially available set for minimal infants. The consists plastic cannula over metal needle direct placement trachea. So far, this device has been evaluated its intended use. Objectives: We hypothesize that allows establishment...
In septic patients, myocardial depression-the so-called cardiomyopathy-needing inotropic support is common. The aim of this study was to compare the dose-responsive electrophysiological and mechanical properties concerning metabolic effects clinically available agents in an isolated rat heart model. After 20 h incubation, both sham-operated (cecal ligation single puncture) hearts from male Wistar rats (n = 64) were received dobutamine, dopamine, epinephrine, or levosimendan at concentrations...
Abstract Background Portal vein complications (PVCs) after pediatric liver transplantation (LT) are sometimes asymptomatic, especially in the early phase, and can threaten both graft patient's survival. Therefore, purpose of this study is to analyze risk factors for portal thrombosis (PVT) stenosis (PVS) LT. Methods All patients ( n = 115) who underwent primary LT at Regensburg University Hospital between January 2010 April 2017 were included study. The pre‐, intra‐, postoperative parameters...
The effects of anesthetics on the injured brain continue to be subject controversial discussion. Since isoflurane has recently been shown induce apoptosis cerebral endothelial cells, this study compared different anesthetic compounds regarding their potential cerebro-vascular apoptosis.The in vitro model blood-brain barrier used consisted astrocyte-conditioned human umbilical vein cells (AC-HUVEC) used. After 24 h deep hypoxia and reoxygenation or control treatment, AC-HUVEC were exposed 0,...
Natural latex rubber products have been known to cause severe anaphylactic reactions during surgery. Even 25 years after the first description of in literature, natural are still used pediatric The following article describes case a healthy 4.5-year old Caucasian boy who simultaneously developed hypotension, tachycardia and bronchospasm surgery for congenital strabismus sursoadductorius under uneventful anesthesia. An allergy test conducted afterwards showed as trigger this intraoperative...