A5038832018- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Appendicitis Diagnosis and Management
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Sphingolipid Metabolism and Signaling
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytomegalovirus and herpesvirus research
University Hospital Regensburg
2015-2024
Gemeinschaftsklinikum Mittelrhein
2022-2024
Johannes Gutenberg University Mainz
2024
Conway School of Landscape Design
2015
University of Central Arkansas
2015
Heidelberg University
2006-2013
University Hospital Heidelberg
2007-2013
Chirurgische Universitätsklinik Heidelberg
2010
Cardiff University
2006
University of Education Schwaebisch Gmuend
2004
Acute cholecystitis is a common disease, and laparoscopic surgery the standard of care.Optimal timing for acute remains controversial: either early shortly after hospital admission or delayed elective conservative treatment with antibiotics.The ACDC ("Acute Cholecystitis-early versus antibiotic therapy Delayed Cholecystectomy") study randomized, prospective, open-label, parallel group trial. Patients were randomly assigned to receive immediate within 24 hours (group ILC) initial treatment,...
Liver ischemia/reperfusion (IR) injury is caused by a heavily toothed network of interactions cells the immune system, cytokine production, and reduced microcirculatory blood flow in liver. These complex networks are further elaborated multiple intracellular pathways activated cytokines, chemokines, danger-associated molecular patterns. Furthermore, ionic disturbances especially mitochondrial disorders play an important role leading to apoptosis necrosis hepatocytes IR injury. Overall,...
Background and Aim: According to several guidelines, both invasive non-invasive tests can be used detect Helicobacter pylori (H. pylori). Invasive methods include H. culture, histological staining, rapid urease (RUTs) PCR. Non-invasive breath test, stool antigen serum IgG testing. The aim of our study was compare all commercially available RUTs histology in Germany. Material Methods: One hundred fifty patients were enrolled study, irrespective proton pump inhibitors (PPIs) or antibiotic use....
nervous system dysfunction, rhabdomyolysis, arrhythmias, disseminated intravascular coagulation and hepatic failure, not uncommon followed by death [4] .The current model of heat stroke favors hyperthermia as trigger, while endotoxaemia drives the disease.However, patholog y is fully understood [2] .In athletes undergoing intense training a variety immune gastrointestinal disturbances can occur.We here describe two completely different causes resulting in acute severe liver failure leading...
Abstract Background and Aim: Liver histology still represents the gold standard for assessment of liver inflammation, necrosis, fibrosis. The least cumbersome way obtaining tissue is percutaneous biopsy. aim this retrospective study was to compare complications following biopsy in in‐ outpatients evaluate which patients benefit from highest. Methods: All undergoing at a teaching hospital between January 1990 April 2005 were evaluated indications, impact histology. Results: performed 287...
Hepatitis C virus (HCV)-induced inflammation contributes to progressive liver disease. The chemoattractant protein chemerin is associated with systemic inflammation. We hypothesized that a biomarker predicts the severity of disease in HCV patients. Furthermore, we investigated whether serum levels change during course treatment using direct-acting antivirals (DAAs). Therefore, measured concentration cohort 82 HCV-infected patients undergoing DAA treatment. Serum was positively leukocyte...
Lenvatinib is a multikinase inhibitor approved for systemic first line treatment of hepatocellular cancer (HCC) in patients with compensated liver cirrhosis (LC) and unaltered function. We aimed to evaluate the efficiency tolerability lenvatinib HCC real world setting, also including advanced LC impaired function.Retrospectively, 35 BCLC stages B, C D were screened. After drop-out exclusion not receiving active > 2 weeks, 28 (27 male; median age 64.7) included analysis.Fourteen (male, 62.7)...
A rapid decline of liver stiffness (LS) was detected by non-invasive methods in patients with chronic hepatitis C (HCV) infection during treatment direct-acting antivirals (DAA).To investigate the influence inflammation on LS.We prospectively examined LS sonographic shear-wave elastography 217 DAA therapy from initiation (BL) to 12 weeks after end (SVR12). Demographic data, laboratory findings and serum levels cytokines were determined.Values decreased 1.86 m/s 1.68 (p = 0.01) which most...
Hepatitis C virus (HCV) infection affects ceramide metabolism, and, here, we have evaluated associations of eight serum species with viral load, genotype, and disease markers in 178 patients chronic HCV. In this cohort, d18:1;O2/16:0 was higher the 20 diabetic compared to without complication. Moreover, d18:1;O2/24:0 negatively correlated age. Of note, all but 26:0 were diminished liver cirrhosis exception d18:1;O2/16:0, model for end-stage (MELD) score. Most ceramides are carried...
Little is known about the parameters and factors that determine intracellular distribution of hepatitis B virus core protein (HBc). In order to study HBc in living cells, was tagged with green fluorescent (GFP). Being assembly-incompetent, GFP-fusion distributed equally throughout cell. Mutational inactivation serine-phosphorylation sites within C-terminal region led predominantly intranuclear localization. Phosphorylation these targets, presumably by an SR domain kinase, resulted a...
With the approval of new direct acting antiviral agents (DAA), therapeutic options for patients with chronic hepatitis C virus (HCV) infection are now generally available before and after liver transplantation (LT). Interferon-free DAA regimens highly effective therapies provide a good safety profile. However, body clinical evidence in this patient population is limited best treatment strategies on waiting list (de)compensated cirrhosis LT not well defined. The following recommendations...
Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted lipid metabolism for treatment of HCC. Very little is known about hepatitis B virus (HBV) and C (HCV)-related hepatic disturbances in non-malignant cancer tissues. The present study showed that triacylglycerol cholesterol concentrations were similar tumor adjacent HBV HCV liver, not induced HCC Higher levels free cholesterol, polyunsaturated phospholipids diacylglycerol species...
Hepatitis C virus (HCV) infection alters lysophosphatidylcholine (LPC) metabolism, enhancing viral infectivity and replication. Direct-acting antivirals (DAAs) effectively treat HCV rapidly normalize serum cholesterol. In serum, LPC species are primarily albumin-bound but also present in lipoprotein particles. This study aims to assess the impact of eradication on levels patients infected with HCV. Therefore, 12 different were measured by electrospray ionization tandem mass spectrometry...
Abstract Background Acute cholecystitis occurs frequently in the elderly and patients with gall stones. Most cases of severe or recurrent eventually require surgery, usually laparoscopic cholecystectomy Western World. It is unclear whether an initial, conservative approach antibiotic symptomatic therapy followed by delayed elective surgery would result better morbidity outcome than immediate surgery. At present, treatment generally determined patient first sees a surgeon gastroenterologist....
Summary Little is known about the ability of hepatitis C virus (HCV) to alter early innate immune responses in infected patients. Previous studies have shown that natural killer (NK) cells are functionally impaired after interaction recombinant HCV glycoprotein E2 with co-stimulatory CD81 molecule vitro; however, functional consequences a prolonged contact NK particles remained unclear. We examined phenotypes purified, interleukin-2-activated from healthy donors and genotype 1b patients...