A5055319231- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Corneal Surgery and Treatments
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Pluripotent Stem Cells Research
- Spinal Cord Injury Research
- Genetics and Physical Performance
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Sport Psychology and Performance
- Sports and Physical Education Studies
- Healthcare during COVID-19 Pandemic
- Education and Digital Technologies
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Advanced Cellulose Research Studies
- Science, Research, and Medicine
- Preterm Birth and Chorioamnionitis
- Radiopharmaceutical Chemistry and Applications
Universidade Positivo
2012-2024
Pontifícia Universidade Católica do Paraná
2023
Colégio Pedro II
2023
University of Minho
2022
Universidade Tecnológica Federal do Paraná
2014
Universidade Federal do Paraná
2007-2008
Aim . The effects of cryopreservation on adipose tissue‐derived mesenchymal stem cells are not clearly documented, as there is a growing body evidence about the importance adipose‐derived for regenerative therapies. aim this study was to analyze human phenotypic expression (CD34, CD45, CD73, CD90, CD105, and CD49d), colony forming unit ability, viability, differentiation potential before after cryopreservation. Materials Methods 12 samples tissue were collected from healthy donor using...
To analyze the functional and anatomical-pathological effect of transplantation bone marrow mononuclear cells associated to aquatic physical activity after myocardial infarction in rats.Twenty-one rats were induced by infarction, through left coronary artery ligation. After a week, animals subjected echocardiography for evaluation ventricle ejection fraction (LVEF, %) dyastolic end systolic volume (EDV, ESV, ml), randomized stem cells. The divided into four groups: sedentary group without...
Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need development new therapeutic modalities. The amniotic membrane has been used various diseases, such as conjunctive defects; however, mechanisms behind its repair functions are unclear. Regenerative medicine seeking newer alternatives among them, biomaterials emerged in recent years developing manipulating molecules, cells, tissues or organs grown laboratories order to replace...
The difficulty in the regeneration of cardiomyocytes after myocardial infarction is a major cause heart failure. Together, amniotic membrane and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) can help recovery cardiomyocyte, as they present many growth factors anti-inflammatory effect, respectively. objective this study to compare efficacy Human Decellularized Amniotic Membrane Scaffold (AHAS) loaded with 15d-PGJ2 improving ventricular function rat model postinfarct dysfunction. Myocardial was...
Introduction: The systematic analysis of cancer markers and the impact artificial intelligence (AI) on early detection therapeutic approach are crucial in today’s medical field. Cancer represents a significant global burden morbidity mortality, making identification priority for effective disease management. This study aims to explore recent advancements characterization indicators, including genetic, molecular, protein, imaging biomarkers. Objective: To analyze latest advances identifying...
Introduction: Most cardiomyocytes do not regenerate after myocardial infarction.Porcine small intestinal submucosa has been shown to be effective in tissue repair.Objective: To evaluate regeneration and functional effects of SIS implantation pigs left ventriculotomy.Methods: Fifteen were assigned two groups: porcine (SIS) (N=10) control (N=5).The group underwent a mini sternotomy, ventriculotomy placement patch.The sham procedure.Echocardiography was performed before 60 days the surgical...
Chronic inflammatory diseases are disorders multifactorial growing on elderly and diabetic populations.15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) acts in protective role against oxidative stress inflammation both vivo vitro.Here, we present a simple method to incorporate 15d-PGJ2 nanoparticles acellular human amniotic membrane scaffold, potential local anti-inflammatory delivery system.After completely removing the cells with sodium dodecyl sulphate mechanical approach, seeded Vero...
This study analysed the adaptation of football athletes to competitive stressors regarding upcoming match. For that, adopted a cross-sectional methodology using critical incident approach. The participants were 352 young male athletes, aged between 15 and 19 years (M = 16.91, SD 0.99), who competing in national championship. results indicated that cognitive appraisal partially mediated relationship emotions: perceived as challenge, tended feel more control over situation resourceful (coping...
Regenerative medicine has now emerged as one of the most promising treatments for patients suffering from damaged tissue.Tissue engineering currently been based on technology using bacterial celluloses (BC) scaffolds alternatives extracellular matrix.Several types matrix were projected successfully to cultivate different cells, such as, example, Chitosan [poly-(β-1/4)-2-amino-2-deoxy-D-glucopyranose], alginate, gelatin or collagen scaffolds.Nonetheless, insufficient cell proliferation into...
HIGHLIGHTS Alginate/Chitosan is the second most abundant polysaccharide on earth. PRF (platelet-rich fibrin) potential to play adjunct roles in regenerative medicine. 3D printing grafts can increase wound healing capacity. Prospective of combining with different biomaterials promotes tissue regeneration.
Acellular amniotic membrane (AAM) is a biodegradable and biocompatible natural that has wide range of applications in the field pharmaceutics, biomedical, chemical cosmetics industry. One most interesting characteristics AAM its antibacterial anti-inflammatory, anti-angiogenic, anti-fibrosis activity an attractive approach for treating inflammatory disorders, wounds, burns. The isolated use may not be sufficient to produce adequate anti-inflammatory antimicrobial effect fulfill different...
O implante de diversos tipos celulares tem sido proposto para o tratamento lesão da medula espinal após trauma, visando sua regeneração funcional. Objetivos: Avaliar os efeitos funcionais terapia autóloga células derivadas óssea, fração mononuclear no trauma crônico espinal. Métodos: 70 ratos foram submetidos à por impacção, sendo avaliados diariamente quanto função motora, com auxílio escala motora Basso, Beatie e Bresnahan a cada 48 horas, durante pesquisa. Catorze dias depois, animais...
Objective: To evaluate the impact of fibromyalgia in daily and associated factors women treated at polyclinic Paraná. Method: A descriptive, cross-sectional study was conducted with individualized data for 52 ≥ 50 years from policlinic Curitiba Paraná State, Brazil. Data were collected an online survey quality life assessed by one specific instrument, Fibromyalgia Impact Questionnaire (FIQ). Verbal or written informed consent obtained all participants. Results: total 157 patients completed...
Cancer is a global problem that in addition to physical, emotional and physiological causes economic social impacts. The p53 gene tumor suppressor found many malignant benign tumors; this has the primary function of keeping cells at rest after damaging DNA. acts maintenance cellular homeostasis, mainly through autophagy, playing role cell cycle arrest, when necessary, thus avoiding mutated DNA replication. When oncogenic environment cases it mutated, losing much its efficiency allowing...
One of the biggest challenges professional, scientific and technological education integrated into secondary is to provide learning students who, in addition having a large workload at educational institution, spend 3 hours or more on public transport every day and, short time left, they need work.Faced with this reality, classes active methodologies can be way engage these who already arrive classroom exhausted, making it possible promote cognitive learning, critical thinking, communication...
Abstract The aim of this study was to analyze adipose tissue-derived mesenchymal stem cells (AT-MSCs) using the Pap test as a first screening step evaluate genetic stability. Human tissue from six healthy female donors obtained elective liposuction procedures. were isolated, cultivated at P2/P3, characterized by flow cytometric analysis, and differentiation induced. AT-MSCs stained Papanicolaou staining analyzed according Bethesda classification, viability-apoptosis relationships evaluated....