A5061600942- Viral Infections and Outbreaks Research
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Cancer-related Molecular Pathways
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Beijing Shijitan Hospital
2021
Capital Medical University
2021
Zhengzhou University
2015-2019
Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cell viability rapid proliferation. Pyruvate kinase muscle (PKM) rate-limiting enzyme the final step glycolysis. Herein, we report PKM potential therapeutic target triple-negative breast (TNBC) cells. We found PKM1 or PKM2 highly expressed TNBC tissues Knockdown significantly suppressed proliferation migration, strongly reduced S phase induced G2...
SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported that viral induce syncytia formation within cells expressing ACE2 spike protein, leading production of micronuclei with an average rate about 4 per syncytium (> 93%). Remarkably, these were manifested a high level both DNA damage response cGAS-STING signaling,...
Although targeting cancer metabolism is a promising therapeutic strategy, clinical success depends on accurate molecular and metabolic subtyping. Here, this study reports two metabolism-based subtypes associated with the ketogenic treatment of colon cancer: glycolytic (glycolysis
Abstract SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported that viral induce syncytia formation within cells expressing ACE2 spike protein, leading production of micronuclei with an average rate about 4 per syncytium (> 93%). Remarkably, these were manifested a high level both DNA damage response cGAS -STING...