A5071024122- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Pharmacogenetics and Drug Metabolism
- Analytical Methods in Pharmaceuticals
- Metabolism and Genetic Disorders
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
- Erythropoietin and Anemia Treatment
- Diabetes Treatment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism, Diabetes, and Cancer
- Gout, Hyperuricemia, Uric Acid
- Chemotherapy-induced organ toxicity mitigation
- Eosinophilic Disorders and Syndromes
- Multiple and Secondary Primary Cancers
- Pediatric Hepatobiliary Diseases and Treatments
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Renal Transplantation Outcomes and Treatments
- Adenosine and Purinergic Signaling
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Endoplasmic Reticulum Stress and Disease
Lanzhou University
2016-2025
First Hospital of Lanzhou University
2016-2025
Zhejiang Chinese Medical University
2024
Hebei Medical University
2024
Zhejiang University
2024
First Affiliated Hospital of Hebei Medical University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2009-2023
Zhongnan Hospital of Wuhan University
2012
Wuhan University
2012
Abstract The organic anion-transporting polypeptide 1B3 and P-glycoprotein (P-gp) provide efficient directional transport (OATP1B3-P-gp) from the blood to bile that serves as a key determinant of hepatic disposition drug. Unfortunately, there is still lack effective means evaluate disposal ability mediated by transporters. present study was designed identify suitable endogenous biomarker for assessment OATP1B3-P-gp function in liver. We established stably transfected HEK293T-OATP1B3...
Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug toxin excretion. Unfortunately, there are no biomarkers to evaluate their function. The aim this study was identify characterize endogenous biomarker renal OATs-MRP4 channel. Twenty-six uremic toxins were selected as candidate compounds, which kynurenic acid identified a potential assessing protein-binding ratio uptake in OAT1-, OAT3-,...
Abstract The renal tubular organic cation transporter 2 (OCT2) and multidrug toxin extrusion protein 1 (MATE1) mediate the vectorial elimination of many drugs toxins from kidney, endogenous biomarkers for transport (OCT2‐MATE1) would allow more accurate drug dosing help to characterize drug–drug interactions toxicity. Human serum uptake in OCT2‐overexpressing cells metabolomics analysis were carried out. Potential verified vitro vivo . specificity was validated overexpressing sensitivity...
A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed validated for the simultaneous quantitation of metformin (MTF), metoprolol (MET), α-hydroxymetoprolol (HMT) O-desmethylmetoprolol (DMT) in rat plasma using paracetamol as an internal standard (IS), respectively. The sample preparation involved a protein-precipitation with methanol after addition IS. separation performed on Agilent HC-C18 column (4.6 × 250 mm, 5 µm) at flow rate 1.0...
ABSTRACT Isoniazid (INH) and rifampicin (RFP), two front‐line drugs used in tuberculosis therapy, may lead to seriously hepatotoxicity. The current study was carried out investigate the hepatoprotective effects of hesperidin against INH‐ RFP‐induced oxidative damage. liver injury animal model rats induced by INH (75 mg/kg) RFP (150 coadministration for 7 days, hesperidin, at dose 50, 100, 200 mg/kg, orally administered 2 h before administration. biochemical pathologic examinations were...
Objective: To systematically identify early biomarkers of cisplatin-induced acute kidney injury (AKI) in rats.
Abstract Background Wolfram syndrome (WS) is a rare autosomal recessive multisystem neurodegenerative disease characterized by non-autoimmune insulin-dependent diabetes mellitus, optic atrophy, sensorineural deafness, and as the main features. Owing to clinical phenotypic heterogeneity, misdiagnosis rate high. However, early accurate diagnosis comprehensive management are key improving quality of life prolonging life. Results Eleven patients from seven WS pedigrees with 10 mutation sites...
The usage of irinotecan hydrochloride (CPT-11) chemotherapy is hindered by its dose-limiting diarrhea which appears to be associated with the intestinal exposure SN-38, active metabolite CPT-11. Hesperidin, a safe and natural food ingredient flavonoid, exhibits various biological properties. Accumulated evidence showed that regulatory effect hesperidin on expression Mrp2 in liver may one critical factors controlling biliary excretion SN-38. This study examined pharmacokinetics CPT-11 SN-38...
A simple, specific and sensitive LC-MS/MS method was developed validated for the simultaneous determination of metoprolol (MET), α-hydroxymetoprolol (HMT) O-desmethylmetoprolol (DMT) in rat plasma. The plasma samples were prepared by protein precipitation, then separation analytes performed on an Agilent HC-C18 column (4.6 × 250 mm, 5 µm) at a flow rate 1.0 mL/min, post-column splitting (1:4) used to give optimal interface rates (0.2 mL/min) MS detection; total run time 8.5 min. Mass...
Renal fibrosis is relentlessly progressive and irreversible, a life-threatening risk. With the continuous intake of high-purine diet, hyperuricemia has become health risk factor in addition to hyperglycemia, hypertension, hyperlipidemia. Hyperuricemia also an independent for renal interstitial fibrosis. Numerous studies have reported that increased mast cells (MCs) are closely associated with kidney injury induced by different triggering factors. This study investigated effect MCs on rats...
Abstract Objective To explore the predictive value of interleukin-6 (IL-6) combined with human neutrophil lipocalin (HNL) stroke-associated pneumonia (SAP) in patients who were diagnosed acute ischemic stroke (AIS). Methods 108patients divided into two groups: group (52 cases) and non-pneumonia (56 cases), according to whether developed SAP within 7 days admission. General information was compared between groups, like age, gender, history hypertension, diabetes mellitus, cardiovascular...
Gallbladder cancer is a major health concern in China, and awareness of the associated incidence mortality rates particularly important given aging population. To determine trends gallbladder over 12 years quantitatively analyze influence demographic factors on these China. We performed retrospective study 98,860 Chinese citizens using Cancer Registry, national database. data pertaining to patients treated between 2005 2017 were collected. Joinpoint regression models used estimate annual...
Hepatic transporters and drug metabolizing enzymes (DMEs) play important roles in the pharmacological effects (or) side-effects of many drugs, are regulated by several mediators, including neurotransmitters. This work aimed to investigate whether serum levels 5-hydroxytryptamine (5-HT) affected expression hepatic or DMEs. The was assessed using Western-blot technique a 2,4,6-trinitrobenzenesulfonic-acid-induced rat model post-infectious irritable bowel syndrome (PI-IBS), which 5-HT were...
Background . The interrelation between obesity and autoimmune thyroid diseases is complex has not been confirmed. aim of the present study was to observe relationship autoimmunity obesity, especially abdominal in a large population. Methods A total 2253 residents who had lived Xinjiang for more than 3 years were enrolled. Serum hormone concentration, autoantibodies, lipid parameters, Weight, height, waist hip circumference measured. Results prevalence peroxidase antibody (TPOAb) and/or...