A5082904873- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Emergency and Acute Care Studies
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma Management and Diagnosis
- Lung Cancer Treatments and Mutations
- Urticaria and Related Conditions
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
- Disaster Response and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Disaster Management and Resilience
- Thermal Regulation in Medicine
- Safety and Risk Management
- Cardiac Ischemia and Reperfusion
Nanjing Medical University
2022-2024
Wuxi People's Hospital
2022-2024
Tongji University
2014-2022
Second Affiliated Hospital of Zhejiang University
2005-2015
Zhejiang University
2005-2014
National Natural Science Foundation of China
2010
Sir Run Run Shaw Hospital
2009
Ministry of Education of the People's Republic of China
2009
Abstract Introduction Early detection of pneumothorax in multiple trauma patients is critically important. It can be argued that the efficacy ultrasonography (US) for enhanced if it performed and interpreted directly by clinician charge patients. The aim this study was to assess ability emergency department clinicians perform bedside US detect size with trauma. Methods Over a 14 month period, treated were enrolled prospective study. Bedside Portable supine chest radiography (CXR) computed...
Schizophrenia is a debilitating familial neuropsychiatric disorder which affects 1% of people worldwide. Although the heritability for schizophrenia approaches 80% only small proportion overall genetic risk has been accounted for, and to date limited number loci have definitively implicated. We identified recently through in vitro functional studies, novel serine/threonine kinase gene, unc-51-like 4 (ULK4), as rare factor major mental disorders including schizophrenia. Now using approach...
Lung adenocarcinoma (LUAD) has emerged as one of the most aggressive lethal cancers. Anoikis serves programmed apoptosis initiated by detachment cells from extracel-lular matrix. Cuproptosis is distinct traditional cell death modalities. The above two modes are both closely related to tumor progression, prognosis, and treatment. However, whether they have synergistic effects in LUAD deserves further investigation.The anoikis-related prognostic genes (ANRGs) co-expressed with...
The potential pathogenic mechanism of idiopathic pulmonary fibrosis is widely recognized to involve immune dysregulation. However, the current pool studies has yet establish a unanimous agreement regarding correlation between various types cells and IPF.
Itch, chronic itch in particular, can have a significant negative impact on an individual's quality of life. However, the molecular mechanisms underlying processing central nervous system remain largely unknown. We report here that activation ERK signaling spinal cord is required for sensation. activation, as revealed by anti-phosphorylated ERK1/2 immunostaining, observed dorsal horn mice treated with intradermal injections histamine and compound 48/80 but not chloroquine or SLIGRL-NH2,...
Immune checkpoint blockade (ICB) only works well for a certain subset of patients with non-small cell lung cancer (NSCLC). Therefore, biomarkers patient stratification are desired, which can suggest the most beneficial treatment.In this study, three datasets (GSE126044, GSE135222, and GSE136961) immunotherapy from Gene Expression Omnibus (GEO) database were analyzed, seven intersected candidates extracted as potential ICB followed by validation The Cancer Genome Atlas (TCGA) dataset in-house...
Background The nervous system, through the vagus nerve and its neurotransmitter acetylcholine, can down-regulate systemic inflammation in vivo , recently, a role of brain cholinergic mechanisms activating this anti-inflammatory pathway has been indicated. Galanthamine is cholinesterase inhibitor one centrally acting agents available clinic. This study aimed to evaluate effect galanthamine on circulating tumor necrosis factor alpha (TNF-α) rats with lipopolysaccharide-induced peritonitis...
Cancer invasion and metastasis, involving a variety of pathological processes cytophysiological changes, contribute to the high mortality lung cancer. The type 1 insulin-like growth factor receptor (IGF-1R), associated with cancer progression invasion, is potential anti-invasion anti-metastasis target in To inhibit invasive properties cells, we successfully down-regulated IGF-1R gene expression A549 human cells by small interfering RNA (siRNA) technology, evaluated its effects on...
Acute itch is divided into histamine- and non-histamine-dependent subtypes, our previous study has shown that activation of ERK signaling in the spinal dorsal horn (SDH) required selectively for histamine-induced sensation. Morphological characteristics pERK-expressing neurons are exploring mechanism underlying To investigate whether supraspinally-projecting neurons, we injected Fluorogold (FG) ventrobasal thalamic complex (VB) parabrachial region, two major ascending sites rodents. A small...
Trauma is statistically a significant cause of mortality among patients across countries. Nevertheless, the precise correlation between genetic diagnostic markers and intricate mechanism trauma remains indistinct. Our study exclusively centered on selected three trauma-related datasets from Gene Expression Omnibus (GEO) database, all which had blood samples collected within post-traumatic 12 h. Differential gene screening, WGCNA Cytoscape software were employed to analyze two datasets, with...
Background: Lung adenocarcinoma (LUAD) represents the most prevalent type of lung cancer. SHOX2 and RASSF1A methylation have been identified as important biomarkers for diagnosis prognosis Bronchoalveolar lavage fluid (BALF) exhibits good specificity sensitivity in diagnosing pulmonary diseases, but its acquisition is challenging may cause discomfort to patients. In clinical, plasma samples are more convenient obtain than BALF; however, there little research on concurrent detection plasma....
To assess whether these characteristics of less misclassification and greater area under receiver operator characteristic (ROC) curve the new injury severity score (NISS) are better than (ISS) as applying it to our multiple trauma patients registered into emergency intensive care unit (EICU). This was a retrospective review registry data from 2 286 consecutively EICU January 1,1997 December 31, 2006 in Second Affiliated Hospital, Medical School Zhejiang University China. Comparisons between...
We investigated the feasibility and efficacy of bone marrow mesenchymal stem cells (BMSCs)-derived neural stem-like (MS-NSCs) therapy on injured brain in rats after severe acute carbon monoxide (CO) poisoning.Controlled animal study.Research laboratory a university hospital.Sprague-Dawley weighing 230 +/- 20 g 90 10 g.The were exposed to 1000 ppm CO air for 40 minutes then 3000 another until they lost consciousness. Approximately 7 x allogeneic BMSCs or MS-NSCs labeled with BrdU infused into...
PTEN is known as a tumor suppressor and plays essential roles in brain development. Here, we report that primary sensory neurons involved processing itch thermal information adult mice. Deletion of the dorsal root ganglia (DRG) achieved Drg11-CreER: PTENflox/flox (PTEN CKO) mice with oral administration tamoxifen, CKO develop pathological elevated responses on exposure to various pruritogens. deletion leads ectopic expression TRPV1 MrgprA3 IB4+ non-peptidergic DRG neurons, responsive...
The aim of this study was to explore the protective effect basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain induced by four vessels occlusion systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection vessels; B, intravenous infusion normal saline after for 6 h; C, 30 microg/kg bFGF injected intravenously at onset reperfusion, then infused with 10 microg/(kg.h) h. Serum neuron...
Background Among the deaths due to trauma, about one half of patients suffer from road traffic injury (RTI). Most RTI complicate acute respiratory distress syndrome (ARDS) and severe multiple injuries. ARDS is a major contributor morbidity mortality in trauma patients. Although many injuries conditions are believed be associated with independent risk factors patients, their relative importance development undefined. We hypothesize that not all traditional impacting independently strictly...