A5051344721- Ethics in medical practice
- Ethics and Legal Issues in Pediatric Healthcare
- Artificial Intelligence in Healthcare and Education
- Ethics in Clinical Research
- Genetic and Kidney Cyst Diseases
- Torture, Ethics, and Law
- Reproductive Health and Technologies
- Medical Malpractice and Liability Issues
- Organ Donation and Transplantation
- Microtubule and mitosis dynamics
- Reproductive Health and Contraception
- Cardiac Arrest and Resuscitation
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Planarian Biology and Electrostimulation
- Neuroethics, Human Enhancement, Biomedical Innovations
- Biomedical and Engineering Education
- Sexual Differentiation and Disorders
- Machine Learning in Healthcare
- Pediatric Urology and Nephrology Studies
- Advanced Memory and Neural Computing
- War, Ethics, and Justification
- Diabetic Foot Ulcer Assessment and Management
- Neuroscience of respiration and sleep
- Pharmaceutical industry and healthcare
Cardiff and Vale University Health Board
2021-2025
Manchester Academic Health Science Centre
2022-2024
University of Manchester
2022-2024
University Hospital of Wales
2024
Manchester University NHS Foundation Trust
2018-2021
Tongji University
2016-2021
National Health Service Wales
2021
University of Aberdeen
2016-2021
Manchester Metropolitan University
2018-2020
Institute of Medical Sciences
2020
Abstract With the increasing prevalence of artificial intelligence (AI) and other digital technologies in healthcare, ethical debate surrounding their adoption is becoming more prominent. Here I consider issue gaining informed patient consent to AI-enhanced care from vantage point United Kingdom’s National Health Service setting. build my discussion around two claims World Organization: that healthcare services should not be denied individuals who refuse there no precedence seeking care....
Schizophrenia is a debilitating familial neuropsychiatric disorder which affects 1% of people worldwide. Although the heritability for schizophrenia approaches 80% only small proportion overall genetic risk has been accounted for, and to date limited number loci have definitively implicated. We identified recently through in vitro functional studies, novel serine/threonine kinase gene, unc-51-like 4 (ULK4), as rare factor major mental disorders including schizophrenia. Now using approach...
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial at perinatal stages disrupts the establishment barrel cortex and relevant callosal connections, its long-term effect on adult behavior remains elusive. In this study, we investigated behavioral phenotypes mice with unilateral transection infraorbital nerve (ION) postnatal day 3 (P3). ION-transected had normal locomotor activity, motor coordination, olfaction, anxiety-like behaviors, novel...
Ectogenesis (artificial wombs) might soon become a reality. This paper will analyse how the development of such technologies affect Judith Jarvis Thomson’s defence abortion, and what potential consequences this be for society. Thomson attempts to justify abortion by appealing mother’s right bodily autonomy. We argue that once these have been developed, can no longer justified appeals. As result, when justifying Thomson-style arguments work, very different strategy adopted those wishing its...
The cilium of a cell translates varied extracellular cues into intracellular signals that control embryonic development and organ function. dynamic maintenance ciliary structure function requires balanced bidirectional cargo transport involving intraflagellar (IFT) complexes. IFT172 is member the IFT complex B, mutation associated with pathologies including short rib thoracic dysplasia, retinitis pigmentosa Bardet-Biedl syndrome, but how it underpins these conditions not clear. We used WIM...
The GTPase ARL13B is localized to primary cilia; small cellular protrusions that act as antennae. Its defective hennin (HNN) variant linked causally with Joubert Syndrome, a developmental ciliopathy attributed poor sensing of extracellular chemical gradients. We tested the hypothesis impaired detection voltage gradients also contributes HNN phenotype.In vitro, electric fields stimulated migration wild type (WT) and fibroblasts toward cathode but field only increased speed WT cells. Cilia on...
A key question has been underexplored in the literature on conscientious objection: if a physician is required to perform 'medical activities,' what medical activity? This paper explores by employing teleological evaluation of medicine and examining analogy military conscripts, commonly cited objection debate. It argues that physicians (and other healthcare professionals) can only be expected support acts - directed towards their patients' health. That is, cannot forced provide or services...
The English cases of Charlie Gard and Alfie Evans involved a conflict between the desires their parents to preserve children’s lives judgments medical teams in pursuit clinically appropriate therapy. treatment children required was clearly extraordinary, including wide array advanced life-sustaining technological support. exemplify clash worldviews rooted different philosophies life care. article highlights differing perspectives on parental authority care England, Canada, United States....
Abortion pill reversal (APR) treatment aims to halt an initiated medical abortion, wherein a pregnant woman takes progesterone after having taken the first of two consecutive abortion pills, typically because she has changed her mind and no longer wants abort pregnancy. It is controversial intervention, generally supported by those identifying as pro-life opposed pro-choice. This paper examines whether, in principle, with pro-choice view should support APR. We firstly examine commitments...
Humans often seek to improve themselves, whether through self-discipline or the use of science and technology. At some point in future, techniques might become available that will change humans such a degree they have be regarded as something other than human: posthuman. This essay tries define at which human-to-posthuman metamorphosis may occur. is achieved by discerning what it makes human substance distinct, i.e. essence. accomplished examining features body, looking mode existence...
There have been repeated calls to ensure that clinical artificial intelligence (AI) is not discriminatory, is, it provides its intended benefit all members of society irrespective the status any protected characteristics individuals in whose healthcare AI might participate. also tailored local population which being used fit-for-purpose. Yet, there be a clash between these two since tailoring an reduce effectiveness when care who are represented population. Here, I explore bioethical concept...
Patients need to be given the relevant information able give informed consent, which might require disclosure of a provisional diagnosis. Yet, there is no duty patient if that aware this exists but chooses not request it. Diagnostic radiographers and healthcare scientists are often responsible for ensuring patients have consent investigations they undertake, were requested by other clinicians. Here we examine disclose patient’s diagnosis made referring clinician asks as part process...
In his recent paper Hatherley discusses four reasons given to support mandatory disclosure of the use machine learning technologies in healthcare, and provides counters each these reasons. While I agree with Hatherley's conclusion that such disclosures should not be (at least an upfront fashion), raise some problems materiality argument. Finally, another potential problem exists a democratic society: even if (and other authors who share conclusions) arguments are sound, society simple fact...
Babylon 5, like other great sci-fi franchises, touched on important ethical questions. Two conundrums relating to the series' main characters included providing life-saving treatment a child against their parents' wishes and potential involvement with highly beneficial but morally dubious medication. I use these cases discuss some aspects of COVID-19 vaccines' development roll-out, demonstrating that people (be it patients or clinicians) might object vaccines due reasonable ethics...
Disorders of sexual differentiation lead to what is often referred as an intersex state. This state has medical, well some legal, recognition. Nevertheless, the question remains whether persons occupy a in between maleness and femaleness or they are truly men women. To answer this question, another important conundrum needs be first solved: defines sex? The seems rather simple most people, yet when morphology does not coincide with haplotypes, genetics might correlate physiology issue...