A5101754901- Tea Polyphenols and Effects
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Stress Responses and Cortisol
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Gut microbiota and health
- Bipolar Disorder and Treatment
- Nanoplatforms for cancer theranostics
- Thyroid Cancer Diagnosis and Treatment
- Antioxidants, Aging, Portulaca oleracea
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Kidney Disease and Diabetes
- Lipid metabolism and biosynthesis
- Enzyme function and inhibition
- Hydrogen's biological and therapeutic effects
- Phytoestrogen effects and research
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- Nutrition and Health in Aging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Medicinal Plants and Bioactive Compounds
- Heart Rate Variability and Autonomic Control
- Radiopharmaceutical Chemistry and Applications
- Circadian rhythm and melatonin
University of Electronic Science and Technology of China
2021-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2020-2023
University of Tsukuba
2012
Stony Brook University
2011
Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, an increased risk for liver cirrhosis cancer. ELOVL family member 6, elongation of very long chain fatty acids (Elovl6), a microsomal enzyme that regulates the C12-16 saturated monounsaturated (FAs). We have shown previously Elovl6 major target sterol regulatory element binding proteins in it plays critical role development obesity-induced insulin resistance by modifying FA composition. To further investigate...
Microbial metabolites have been indicated to communicate with the host's endocrine system, regulating hormone production, immune-endocrine communications, and interactions along gut-brain axis, eventually affecting occurrence of cancer. Furthermore, microbiota such as short-chain fatty acids (SCFAs) found affect tumor microenvironment boost immunity against tumors. SCFAs, including butyrate acetate, demonstrated exert anti-proliferative anti-protective activity on pancreatic cancer cells....
Purpose: Diabetic nephropathy (DN), a major complication of diabetes mellitus, significantly impacts global health. Identifying individuals at risk developing DN is crucial for early intervention and improving patient outcomes. This study aims to develop validate machine learning-based predictive model using integrated biomarkers. Methods: A cross-sectional analysis was conducted on baseline dataset involving 2184 participants without DN, categorized based their development over follow-up...
Phospho-ibuprofen (P-I; MDC-917) inhibits the growth of colon cancer in mice. Here, we investigated use nanocarriers to improve its pharmacokinetics (PKs) and anti tumour efficacy.The cellular uptake cytotoxicity P-I encapsulated into liposomes micelles, vitro metabolic stability, were determined cultures human adenocarcinoma cells. The performance liposomal was further evaluated PK studies mice, a model xenografts nude mice.Liposomal micellar showed significantly enhanced Liposomal also...
Biological rhythm is closely related to health. We aimed identify the potential correlations of gene polymorphisms type 2 diabetes mellitus (DM) or bipolar disorder (BD), which both have many abnormal rhythmic activities, in a sample Chinese Han origin.A total 136 patients with BD, 166 DM, and 130 healthy controls were collected. screened 28 single nucleotide (SNPs) located genes CLOCK, ARNTL, PER2, PER3, CRY1, CRY2 respectively. Snapshot typing technology was used for genotyping.Both...
Abstract We aimed to explore a new treatment model for type 2 diabetes mellitus (DM) based on rhythm regulation under the framework of psychosomatic medicine. Using psychotropics as regulators, 178 patients with DM were evaluated and divided into three groups: antidiabetic group (AT group), psychotropic (PT combined + (combined course 16 weeks. The West China Psychiatry Association (WCPA) Somatic Symptom Classification Scale (SSCS) was used evaluate each patient. levels hormones in...
Abstract Adrenocortical carcinoma (ACC) is an uncommon, possessive, and highly metastasizable malignancy of the adrenal cortex. Using bioinformatics analysis microarray datasets, this work intended to uncover important molecular entities pathways complicated in ACC metastasis. Three datasets (GSE90713, GSE143383, GSE19750) were obtained from Gene Expression Omnibus (GEO) database, comprising a total 226 samples healthy controls. A collection differentially expressed genes (DEGs) miRNAs...