A5033810197- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Immunotherapy and Immune Responses
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Hearing Loss and Rehabilitation
- Immune Cell Function and Interaction
- Cerebral Venous Sinus Thrombosis
- Olfactory and Sensory Function Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Facial Nerve Paralysis Treatment and Research
- Peripheral Nerve Disorders
- Visual perception and processing mechanisms
- Meningioma and schwannoma management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- melanin and skin pigmentation
- Ocular Surface and Contact Lens
- Liver Disease and Transplantation
- Migraine and Headache Studies
- Head and Neck Anomalies
Kanazawa Medical Center
2020-2023
Komatsu (Japan)
2023
Kanazawa University
2011-2022
Kanazawa University Hospital
2018-2021
Shiga University of Medical Science
1986-2015
Kyoto Medical Center
2008
Kumamoto University
2007
Yamato Municipal Hospital
1994
City Hospital
1994
Shiga University
1980
Host antitumor immune responses may be different between hepatocellular carcinoma (HCC) caused by metabolic disorders and HCC associated with hepatitis virus infection. In this study, we examined the response of tumor‐associated antigen (TAA)–specific T cells cell profile in patients separated cause. Thirty‐two B (HBV)–related HCC, 42 C virus–related 18 nonalcoholic steatohepatitis (NASH)–related were analyzed. The frequencies TAA‐specific cells, expression levels surface markers on each...
Abstract The behaviors and fates of immune cells in cancer patients, such as dysfunction stem-like states leading to memory formation T cells, are intense focus investigation. Here we show, by post hoc analysis peripheral blood lymphocytes hepatocellular carcinoma patients previously undergoing vaccination with tumour-associated antigen-derived peptides our clinical trials (registration numbers UMIN000003511, UMIN000004540, UMIN000005677, UMIN000003514 UMIN000005678), that induced...
From 1975 to 1990, nationwide surveys on Meniere's disease were performed three times by the Research Committee of (1975–76) and Peripheral Vestibular Disorders (1982–84 1990) in Japan. Nine hundred fifty-eight definite Meniere cases, 520 Ist, 230 2nd 148 3rd survey, sampled members Committees. The epidemiological clinical characteristics analyzed compared with such control cases as other vertiginous patients, ENT patients without vertigo, healthy subjects. In disease, male female ratio has...
Meniere's disease is a common inner ear with an incidence of 15 to 50 per 100,000 population. Since thought be triggered by immune insult the ear, we examined intraendolymphatic sac application steroids as new therapeutic strategy for intractable disease.Prospective randomized controlled study.Between 1996 and 2005, enrolled assigned 197 patients three groups in trial: Group I (G-I)- who underwent endolymphatic drainage steroid-instillation; II (G-II)-those without III (G-III)-those declined...
Summary Despite curative locoregional treatments for hepatocellular carcinoma (HCC), tumour recurrence rates remain high. The current study was designed to assess the safety and bioactivity of infusion dendritic cells (DCs) stimulated with OK432, a streptococcus-derived anti-cancer immunotherapeutic agent, into tissues following transcatheter hepatic arterial embolization (TAE) treatment in patients HCC. DCs were derived from peripheral blood monocytes hepatitis C virus-related cirrhosis HCC...
Dendritic cells (DCs) are antigen‐presenting with a central role in host immune response. This study analyzed gene expression and DC function hepatitis B virus (HBV) patients, functions impaired because of HBV, identified the genes related to these functions. Peripheral blood mononuclear from 64 HBV patients 19 healthy controls were analyzed. DCs stained antibodies against human leukocyte antigen–DR/Lin‐1/CD123/CD11c separated into plasmacytoid (pDCs) myeloid by fluorescence‐activated cell...
AbstractThe feasibility of furosemide test for the detection endolymphatic hydrops has previously been discussed (Authors, 1973, 1975). The glycerol also reported as being effective same purpose but only in Meniere patients with fluctuating hearing loss (Klockhoff & Lindblom, 1966). In 48 Meniere's disease, both (F-test) and (G-test) were performed on 51 ears including 3 cases bilateral involvement. average value urine volume F-test was significantly greater than that G-test. decrease...
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, although there no proven therapeutic procedure following termination of sorafenib, hepatic arterial infusion chemotherapy (HAIC) may be a option in HCC. The aim this study was to evaluate feasibility and efficacy HAIC patients with HCC as subsequent therapy.We retrospectively evaluated 27 consecutive who were treated sorafenib between June 2009 December 2012 at our hospital. Cisplatin (20 mg/m(2) per...
Background & aims The modest consumption of alcohol has been reported to decrease the incidence fatty liver or prevalence steatohepatitis. In this study, we investigated effect light on function and gene expression in patients with non-alcoholic disease (NAFLD). Methods study group was formed 178 diagnosed disease, subclassified into two groups for analysis based daily consumption: non-alcohol consumer (≤20 g ethanol/day). Clinical characteristics, histological features, expression,...
Summary The curative treatments for hepatocellular carcinoma (HCC), including surgical resection and radiofrequency ablation (RFA), do not prevent tumour recurrence effectively. Dendritic cell (DC)-based immunotherapies are believed to contribute the eradication of residual recurrent cells. current study was designed assess safety bioactivity DC infusion into tissues following transcatheter hepatic arterial embolization (TAE) patients with cirrhosis HCC. Peripheral blood mononuclear cells...
Experimental hydrops caused by underabsorption of endolymphatic fluid is a model remissional stage Meniere's disease. In this study, another type model, ie, overproduction fluid, was accomplished applying various pressures into scala media through micropipette via stria vascularis. This could be attacks By using two types the effects glycerol administration and opening sac were discussed.
A survey of 265 Japanese patients with Meniere's disease revealed bilateral involvement in approximately 29% all these patients. Somatic and psychiatric aspects were as follows. (1) The duration the cases was significantly longer than unilateral involvement. (2) An abnormal general condition, a more extensive degree hearing loss neurotic type frequently diagnosed Based on results, it concluded that management prevention aggravation deafness should be part treatment disease.
We investigated the usefulness of three-dimensional audiograms in assessing prognosis during early phase 116 patients with sudden deafness. The initiation time improvement middle-frequency hearing at 15 dB or more was valuable deafness and scale-out types loss. Improvement within 13 days type, 17 those correlated a high incidence marked complete recovery. Patients an initial mean level below 80 dB, whom glycerol test electrocochleography results suggested presence endolymphatic hydrops, had...
In a previous report it was suggested that intravenous administration of furosemid followed by comparative caloric test (the test) could be utilized for detection endolymphatic hydrops (Kitahara et al., 1973). As result the further application upon 161 patients with vertigo, positive results were observed in 80 % typical Menière's disease, 6 atypical 42 labyrinthine syphilis and 27 sudden deafness. labyrinthitis, negative. It is thus concluded provides evidence determining etiology vertigo.
Pancreatic ductal adenocarcinoma (PDAC) is the most life-threating disease among all digestive system malignancies. We developed a blood mRNA PDAC screening using real-time detection PCR to detect expression of 56 genes, discriminate from noncancer subjects. undertook clinical study assess performance system. collected whole RNA 53 patients, 102 subjects, 22 patients with chronic pancreatitis, and 23 intraductal papillary mucinous neoplasms in per protocol analysis. The sensitivity for...
Accurate diagnosis of non-alcoholic steatohepatitis (NASH) from fatty liver disease (NAFLD) is clinically important. Therefore, there a need for easier ways diagnosing NASH. In this study, we investigated the serum acid composition and evaluated possibility using as diagnostic marker NASH.The subjects were 78 NAFLD patients (non-alcoholic [NAFL]: 30, NASH: 48) 24 healthy individuals. Fatty acids extracted tissue identified quantified by gas chromatography. addition, relationship between...
Although bilateral involvement of Meniere's disease is serious enough to produce deafness in both ears, actually little attention has been directed such involvement. Recently, several reports have made concerning the aspects this (1–8). However, lacking mutual agreeable diagnostic criteria for making these and differences characteristics patients with among institutes makes it difficult establish definitive interpretations. In 1988, Vestibular Disorder Research Committee a survey 15...