A5087345779- Metalloenzymes and iron-sulfur proteins
- Electrocatalysts for Energy Conversion
- Liver Disease Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Hydrogen Storage and Materials
- Urban and spatial planning
- Hepatocellular Carcinoma Treatment and Prognosis
- Polyoxometalates: Synthesis and Applications
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Advanced battery technologies research
- Tracheal and airway disorders
- Hepatitis C virus research
- Liver physiology and pathology
- Organ Donation and Transplantation
- Ammonia Synthesis and Nitrogen Reduction
- Injection Molding Process and Properties
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Ion channel regulation and function
- Metal-Catalyzed Oxygenation Mechanisms
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Additive Manufacturing Materials and Processes
- Cancer Research and Treatments
Tokyo Metropolitan Komagome Hospital
2017-2025
University of Hyogo
2014-2023
National Sagamihara Hospital
2020-2022
Nippon Medical School
2008-2022
Osaka Soda (Japan)
2021
Japan Science and Technology Agency
2018-2019
Tokyo Institute of Technology
1997-2019
Kyoto University
1962-2018
Hyogo University
2016-2018
SPring-8
2018
Tracheal intubation in coronavirus disease 2019 (COVID-19) patients creates a risk to physiologically compromised and attending healthcare providers. Clinical information on airway management expert recommendations these are urgently needed. By analysing two-centre retrospective observational case series from Wuhan, China, panel of international experts discussed the results formulated consensus for tracheal COVID-19 patients. Of 202 undergoing emergency intubation, most were males (n=136;...
BackgroundThere is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was assess the safety, tolerability, and effect PRI-724, a small-molecule modulator Wnt signaling, in patients with HCV cirrhosis.MethodsIn single-center, open-label, phase 1 trial, we sequentially enrolled cirrhosis who were classified as Child-Pugh (CP) class A or B. PRI-724 administered continuous intravenous infusion 10, 40, 160 mg/m2/day for six cycles...
H<sub>2</sub>/O<sub>2</sub>biofuel cells utilizing hydrogenases and multicopper oxidases as bioelectrocatalysts are clean, sustainable, environmentally friendly power devices.
We conducted an exploratory study to assess the safety tolerability, and anti-fibrotic effects of PRI-724, a CBP/β-catenin inhibitor, in patients with hepatitis C virus (HCV)- B (HBV)-induced cirrhosis.This multicentre, open-label, non-randomised, non-placebo-controlled phase 1/2a trial was at three hospitals Japan. Between July 27, 2018, 13, 2021, we enrolled HCV- HBV-induced cirrhosis classified as Child-Pugh (CP) class A or B. In 1, 15 received intravenous infusions PRI-724 escalating...
Abstract A [NiFe] hydrogenase (H 2 ase) is a proton‐coupled electron transfer enzyme that catalyses reversible H oxidation; however, its fundamental proton pathway remains unknown. Herein, we observed the protonation of Cys546‐SH and Glu34‐COOH near Ni–Fe site with high‐sensitivity infrared difference spectra by utilizing Ni‐C‐to‐Ni‐L Ni‐C‐to‐Ni‐SI photoconversions. Protonated in Ni‐L state was verified SH stretching frequency (2505 cm −1 ), whereas Cys546 deprotonated Ni‐C Ni‐SI states....
Abstract Nicotinamide mononucleotide (NMN), an intermediate in nicotinamide adenine dinucleotide biosynthesis, is recently attracting much attention for its pharmacological and anti-aging efficacies. However, current commercial products containing NMN are very high-priced because efficient facile methods industrial production limited. In this study, aiming nutraceutical application, we attempted to screen lactic acid bacteria intracellular and/or extracellular production. Using a bioassay...
Abstract [NiFe] hydrogenase catalyzes the reversible cleavage of H 2 . The electrons produced by pass through three Fe–S clusters in to its redox partner. It has been reported that Ni‐SI a , Ni‐C, and Ni‐R states are involved catalytic cycle, although mechanism regulation transition between Ni‐C remain unrevealed. In this study, FT‐IR spectra under light irradiation at 138–198 K show Ni‐L state is an intermediate states. occurred when proximal [Fe 4 S ] p 2+/+ cluster was oxidized, but not...
Primary squamous cell carcinoma of the liver (PSCCL) is an extremely rare disease with a poor prognosis. To date, few cancer-related genetic abnormalities in PSCCL have been reported. This report describes case FGFR2 alterations male patient his 50s. The presented loss appetite and epigastric pain. Computed tomography confirmed irregular mass lymphadenopathy mediastinum right supraclavicular region. Biopsies were obtained from lymph nodes, diagnosis was determined. No other primary lesions...
Hepatocyte apoptosis has been implicated in the progression of nonalcoholic steatohepatitis. However, it is unclear whether induction tumor necrosis factor (TNF)‐α‐mediated hepatocyte simple fatty liver triggers fibrosis. To address this question, high‐fat diet‐fed mice were repeatedly administered D‐galactosamine, which increases sensitivity hepatocytes to TNF‐α‐mediated apoptosis. In treated with a diet plus and fibrosis induced, whereas both inhibited these following gut sterilization...
Different light-induced Ni-L states of [NiFe] hydrogenase from its Ni-C state have previously been observed by EPR spectroscopy. Herein, we succeeded in detecting simultaneously two Desulfovibrio vulgaris Miyazaki F FT-IR A new νCO band at 1890 cm–1 and νCN bands 2034 2047 were detected the spectra H2-activated enzyme under N2 atmosphere basic conditions, addition to 1910 2061 Ni-L2 state. The attributed Ni-L3 comparison spectra. frequencies are lowest among corresponding standard-type...
The C-MAC D-blade is a new, highly angulated, videolaryngoscope blade designed for use in patients with difficult airways. Directing tracheal tube into the trachea any indirect viewing laryngoscope can be difficult, even good view of laryngeal inlet.To determine which introducing strategy most suitable videolaryngoscope.Observational manikin study.Centre Simulation and Patient Safety.Twenty-four anaesthetists at least 12 months' experience.Six introducer strategies (no (TX); hockey stick...
Objective: An open-label noncontrolled study was conducted in subjects with increased oxidative stress burden to evaluate the mental and physical effects of antioxidant astaxanthin.Methods: Of 35 healthy postmenopausal women, 21 high (diacron-reactive oxygen metabolites; d-ROM) were selected, 20 (55.7±4.8 years old, BMI 22.1±3.9) included study, after excluding 1 dropout. In orally treated astaxanthin (Fuji Chemical Industry) at a daily dose 12 mg for eight weeks, Anti-Aging QOL Common...
Abstract Chronic cholestatic liver diseases are characterized by injury of the bile ducts and hepatocytes caused accumulated acids (BAs) inflammation. Wnt/β‐catenin signaling is implicated in organ fibrosis; however, its role fibrosis remains unclear. Therefore, we explored effect a selective cAMP response element‐binding protein‐binding protein (CBP)/β‐catenin inhibitor, PRI‐724, on murine fibrosis. PRI‐724 suppressed induced multidrug resistance 2 knockout (KO), duct ligation, or...
We investigated the influence of spontaneous portosystemic collateral pathways on portal hemodynamics and examined necessity for ligating these vessels in pediatric liver transplantation from living donors. assessed blood flow before, during, after surgery 82 recipients (mean age, 4.2 years), using Doppler ultrasonography. When reconstructed vein was decreased (< 10 ml/min/kg body weight) collaterals persisted during surgery, those were ligated flowmetry again. Spontaneous detected at one or...
In the course of our screening for a new anti-tumor substance, bisabolane sesquiterpenoid endoperoxide, 3,6-epidioxy-1,10-bisaboladiene (EDBD), was isolated from edible wild-plant, Cacalia delphiniifolia. EDBD showed cytotoxicity toward human chronic myelogenous leukemia K562 and prostate carcinoma LNCaP cell lines with IC50 values 9.1 μm 23.4 μm, respectively. DNA fragmentation condensation chromatin, hallmarks apoptosis, appeared in cells after an 18-h treatment EDBD. α-Curcumene,...
Abstract Hepatitis B virus (HBV) reactivation reportedly occurs frequently after hematopoietic stem cell transplantation (HSCT) in resolved HBV-infected patients. Here, 50 patients with HBV infections and scheduled to undergo HSCT were enrolled; all subjects vaccinated three doses of hepatitis vaccine 12 months the incidence was monitored. The patients’ characteristics were: median age, 61 (34–72) years; male/female, 27/19; allogeneic/autologous, 40/6; bone marrow/peripheral blood cells/cord...
Cholecystitis is a major complication after self-expandable metallic stent (SEMS) placement for malignant biliary obstruction. Ischemia one of the risk factors cholecystitis, but little known about influence tumor invasion to feeding artery gallbladder on onset cholecystitis SEMS placement. The aim present study was identify placement.Incidence and nine predictive were retrospectively evaluated in 107 patients who underwent unresectable distal obstruction at Kyoto University Hospital Otsu...
The Ni-SIr state of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F was photoactivated to its Ni-SIa by Ar(+) laser irradiation at 514.5 nm, whereas the Ni-SL light induced a newly identified state, which less active than any other and existed in "as-isolated" enzyme.