A5087665565- Pregnancy and preeclampsia studies
- Sarcoma Diagnosis and Treatment
- Birth, Development, and Health
- DNA Repair Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Carcinogens and Genotoxicity Assessment
- Cancer therapeutics and mechanisms
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Gestational Trophoblastic Disease Studies
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Chemical Synthesis and Analysis
- Cancer Risks and Factors
- Dermatological and Skeletal Disorders
- Cervical and Thoracic Myelopathy
- Clostridium difficile and Clostridium perfringens research
- Inflammasome and immune disorders
- Click Chemistry and Applications
- Prenatal Screening and Diagnostics
- Renal Diseases and Glomerulopathies
- Management of metastatic bone disease
- Toxin Mechanisms and Immunotoxins
- Spine and Intervertebral Disc Pathology
Oita University
2014-2025
Fukuoka University
2004-2023
Hayashibara (Japan)
1998-2021
Nagoya University
2005-2018
Otsu Red Cross Hospital
2017
South China Agricultural University
2014
Japanese Red Cross Narita Hospital
2013
Nagoya Medical Center
2013
National Hospital Organization
2013
Orthopedic One
2010
Interleukin‐18 binding protein is a novel glycoprotein that we successfully cloned and expressed. First, murine interleukin‐18 was purified from the sera of mice with endotoxin shock using ligand affinity chromatography. The cDNA after RT‐PCR mixed primer pair sequences based on partial amino acid sequence analysis. Subsequently, human libraries normal liver as probe. Next, transiently expressed recombinant proteins in COS‐1 cells them culture supernatants. Both did not exhibit species...
Bufalin is a traditional oriental medicines which induces apoptosis in some lines of human tumor cells. It constitutes the major digoxin-like immunoreactive component Chan Su, obtained from skin and parotid venom glands toads. cardioactive C-24 steroids that exhibits variety biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory antineoplastic effects. In terms its anti-tumor activity, bufalin has been demonstrated to inhibit growth tumors,...
Telmisartan, an angiotensin II receptor type 1 blocker, is often used as antihypertension drug, and it has also been characterized a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand. The purpose of this study was to elucidate the antitumor effects telmisartan on endometrial cancer cells. We treated three cell lines with various concentrations telmisartan, we investigated proliferation, apoptosis, their related measurements in vitro. administered nude mice experimental tumors...
A DNA double-strand break (DSB) is one of the most cytotoxic lesions because unrepaired DSBs cause chromosomal aberrations and cell death. Although many physiological occur at replication sites, molecular mechanisms underlying this remain poorly understood. There was therefore a need to develop highly specific method detect DSB fragments containing sites. Here we investigated whether pulsed-field gel electrophoresis (PFGE) combined with visualization sites by immunoblotting using halogenized...
Within the human intestinal tract, dietary, microbial- and host-derived compounds are used as signals by many pathogenic organisms, including Clostridioides difficile . Trehalose has been reported to enhance virulence of certain C. ribotypes; however, such variants widespread not correlated with clinical outcomes for patients suffering from infection (CDI). Here, we make preliminary observations on how trehalose supplementation affects microbiota in an vitro model show that trehalose-induced...
Abstract BACKGROUND Surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) is still challenging, and factors good surgical outcomes are unknown. OBJECTIVE To identify with prospective comparative study. METHODS Seventy-one consecutive patients who underwent decompression instrumented fusion were divided into or poor outcome groups based on ≥50% <50% recovery rates Japanese Orthopaedic Association score. Preoperative, intraoperative, postoperative findings...
Abstract DNA replication inhibitors are utilized extensively in studies of molecular biology and as chemotherapy agents clinical settings. The inhibition often triggers double-stranded breaks (DSBs) at stalled sites, resulting cytotoxicity. In East Asia, some traditional medicines administered anticancer drugs, although the mechanisms underlying their pharmacological effects not entirely understood. this study, we screened Japanese herbal identified two benzylisoquinoline alkaloids (BIAs),...
We present two patients who developed severe protrusion of the conjunctiva and chemosis secondary to Harlequin ichthyosis (HI).Case 1 was a male infant diagnosed with HI had parchment-like appearance conjunctival chemosis. Case 2 female on whom been suspected before birth through ultrasonography. She showed thickened skin over entire body For both cases, vitamin A derivative applied hyperkeratotic layer peeled off every day. Great care taken sterilize moisten ocular surface. The gradually...
Cholecystitis is a major complication after self-expandable metallic stent (SEMS) placement for malignant biliary obstruction. Ischemia one of the risk factors cholecystitis, but little known about influence tumor invasion to feeding artery gallbladder on onset cholecystitis SEMS placement. The aim present study was identify placement.Incidence and nine predictive were retrospectively evaluated in 107 patients who underwent unresectable distal obstruction at Kyoto University Hospital Otsu...
A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 KB. fungicidal most had a considerable effect on selected fungi. Generally bioactivity its better than derivatives. substituted groups orthoand para- positions gave ones meta-position. Keywords: Synthesis, 5-Phenyl-2-furan, Carvacrol derivatives, Antitumor activity, Antifungal activity.
Background . Although radiation exposure is of great concern to expecting patients, little information available on the fetal dose associated with prophylactic internal iliac artery balloon occlusion (IIABO). Here we estimated IIABO in Caesarean section (CS). Cases We report our experience procedure three consecutive patients suspected placenta previa/accreta. Fetal measurements were conducted prior each CS by using an anthropomorphic phantom. Based simulated value, calculated as absorbed...
Platelet-activating factor (PAF) is involved in such reproductive processes as parturition. We investigated the effect of PAF on expression matrix metalloproteinase-1 (MMP-1) and that tissue inhibitor metalloproteinases-1 (TIMP-1) human uterine cervical fibroblasts. Uterine was obtained from patients who underwent cesarean section at term. Collagenase-dispersed fibroblasts were cultured used experiments. receptor identified by use reverse transcription-polymerase chain reaction Southern blot...
Background: There have been no well-documented reports detailing the relationship between skeletal metastasis and tumor markers in a large series of patients. The purpose our study was to assess clinical features serum determine whether are useful modality differential diagnosis metastasis.
Abstract Introduction The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method assessment embryo quality. Objective We aimed to examine metabolic changes in culture medium develop a non-invasive for Methods performed analysis obtained from single blastocyst cultured freezing. Results In total, 187 (39.8%) 469 detectable organic acid metabolites were identified. A significant change ( p < 0.05) was...
The aim of this study was to assess the radiologic and clinical outcome when beta-tricalcium phosphate is used as a bone graft substitute backfill fibular defect that created by harvesting fibula. Fourteen patients who had fibula resections be grafts for tumor were assessed radiographically. Callus formation bridging seen in 12 14 at an average 1.4 months after surgery. In these mostly absorbed replaced newly formed 9.3 all children, 3.2 Only one adult patient complete regeneration Few...
Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken identify the oncological outcomes significance of adjuvant radiotherapy in achieving local control sarcomas. We reviewed 31 consecutive soft tissue (24), bone (7) arising analyzed impact patient characteristics on outcomes. There were seven cases clear cell or epithelioid Two experienced recurrence despite fact that only two received radiotherapy. Sixteen out 18...
Three children treated with bone marrow transplantation for acute lymphoblastic leukemia, Diamond-Blackfan anemia, and congenital amegakaryocytic thrombocytopenia developed secondary osteosarcoma in the left tibia at age of 13, 9 years, respectively, 51, 117, 106 months after transplantation, respectively. Through treatment chemotherapy surgery, all 3 patients are alive without disease. We surveyed literature reviewed 10 cases hematopoietic stem cell (SCT), including our cases. Eight had...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTXylose: The First Ambident Acceptor Substrate for Galactosyltransferase from Bovine MilkTorsten Wiemann, Yoshihiro Nishida, Volker Sinnwell, and Joachim ThiemCite this: J. Org. Chem. 1994, 59, 22, 6744–6747Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a038https://doi.org/10.1021/jo00101a038research-articleACS PublicationsRequest reuse...