Abstract BACKGROUND Botrytis cinerea is one of the most serious plant diseases and severely threatens agricultural production. The rapidly intensifying resistance makes commercial chemical fungicides lose control efficacy. Developing new with novel structures modes action an effective measure to solve this problem. RESULTS In work, 29 sulfonamide compounds containing pinacolone scaffolds were designed synthesized based on active substructure splicing strategy. biological activity assay three...

Abstract BACKGROUND Succinate dehydrogenase inhibitors (SDHIs) play an increasingly important role in controlling plant diseases. However, the similar structures of SDHIs result rapid development cross‐resistance and a clear bottleneck poor activity against oomycetes, therefore need to seek new SDHI fungicides with novel is urgent. RESULTS Innovative pyrazolyl oxime ethers were designed by replacing amide ether based on succinate (SDH) structure, 19 pairs Z ‐ E ‐isomers efficiently prepared...

Peanut stem rot, caused by Sclerotium rolfsii , considerably affects crop productivity. Application of chemical fungicides harms the environment and induces drug resistance. Biological agents are valid eco-friendly alternatives to fungicides. Bacillus spp. important biocontrol that now widely used against several plant diseases. This study aimed evaluate efficacy mechanism a potential agent sp. for controlling peanut rot S. . Here, we isolated strain from pig biogas slurry inhibits radial...

Plant virus diseases are difficult to prevent and control, causing serious economic losses the agricultural production world. To develop new pesticides with antiviral activity, a serial of compounds containing structure pyrimidine moroxydine were synthesized, among which GLY-15 exhibited good activity against tobacco mosaic (TMV), while mechanism remains be clarified.GLY-15 treatment significantly inhibited formation necrotic spots caused by TMV in Nicotiana glutinosa, effectively suppressed...

Anilinopyrimidines are the main chemical agents for management of Botrytis cinerea. However, drug resistance in fungi against this kind compounds is very serious. To explore new potential fungicides B. cinerea, a series 4-phenyl-6-trifluoromethyl-2-amino-pyrimidine (compounds III-1 to III-22) were synthesized, and their structures confirmed by ¹H-NMR, IR MS. Most these possessed excellent fungicidal activity. The III-3 III-13 showed higher activity than positive control pyrimethanil on...

A series of 2-oxocycloalkylsulfonylureas (2) have been synthesized in a six-step, three-pot reaction sequence from readily available cyclododecanone, cycloheptanone, and cyclohexanone. Their structures were confirmed by IR, 1H NMR, elemental analysis. The bioassay indicated that some them possess certain fungicidal activity against Gibberella zeae Petch. In general, compounds containing 12-membered ring (2A) are more active than those 6- or 7-membered (2B, 2C). the 2A, which R is...

Abstract BACKGROUND: With the objective of exploring fungicidal activity 2‐oxocyclohexylsulfonamides (2), a series novel 2‐amino‐6‐oxocyclohexenylsulfonamides (6 to 23) were synthesised, and their activities against Botrytis cinerea Pers. evaluated in vitro vivo . RESULTS: The compounds characterised by IR, 1 H NMR elemental analysis. Bioassay results mycelial growth showed that 6 23 had moderate antifungal B. N...

Abstract In this study, a simple and accurate sample preparation method based on dispersive solid‐phase extraction liquid‐liquid microextraction has been developed for the determination of seven novel succinate dehydrogenase inhibitor fungicides (isopyrazam, fluopyram, pydiflumetofen, boscalid, penthiopyrad, fluxapyroxad, thifluzamide) in watermelon. The watermelon samples were extracted with acetonitrile, cleaned up by procedure using primary secondary amine, concentrated...

To explore new potential fungicides, a series of novel compounds, including 11 2-oxocycloalkylsulfonamide (3) and 21 2-hydroxycycloalkylsulfonamide (4) derivatives, were synthesized their structures confirmed by (1)H nuclear magnetic resonance (NMR), infrared (IR), elemental analysis. The results the bioassay showed that compounds 3 4 possessed excellent fungicidal activity against Botrytis cinerea Pers. both in vitro vivo. with 7- or 8-membered rings is better than those 5-, 6-, 12-membered...

Eighteen N-substituted phenyl-2-acyloxycyclohexylsulfonamides (III) were designed and synthesized by the reaction of phenyl-2-hydroxyl- cycloalkylsulfonamides (I, R1) with acyl chloride (II, R2) in dichloromethane under catalysis TMEDA molecular sieve. High fungicidal active compound N-(2,4,5-trichlorophenyl)-2-(2-ethoxyacetoxy) cyclohexylsulfonamide (III-18) was screened out. Mycelia growth assay against Botrytis cinerea exhibited that EC50 EC80 III-18 4.17 17.15 μg mL−1 respectively, which...

A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 KB. fungicidal most had a considerable effect on selected fungi. Generally bioactivity its better than derivatives. substituted groups orthoand para- positions gave ones meta-position. Keywords: Synthesis, 5-Phenyl-2-furan, Carvacrol derivatives, Antitumor activity, Antifungal activity.

The optimization of fermentation conditions is necessary for field application biological control agents. present study was designed to optimize the Bacillus aerius strain, JS-786 in terms cell dry mass and its antifungal activity against Botrytis cinerea with response surface methodology. A strain bacteria strong isolated from phyllosphere tomato plant identified as B. based on sequence homology 16S rRNA gene. After success preliminary tests, methodology used (medium pH, gelatin percentage,...

Plant disease is one of the most serious problems in agriculture that can damage crops. Chemical fungicides are widely used to control plant diseases, but have led resistance and a series environmental problems. It is, therefore, necessary develop highly effective eco-friendly antimicrobial compounds with novel structures.A hydantoin cyclohexyl sulfonamide derivatives were synthesized through an intramolecular condensation reaction. The bioassay results indicated majority title displayed...

Sulfonyl-containing compounds, which exhibit a broad spectrum of biological activities, comprise substantial proportion and play vital role, not only in medicines but also agrochemicals. As result increasing attention has been paid to the research development sulfonyl derivatives. A series thirty-eight 2-substituted phenyl-2-oxo- III, 2-hydroxy- IV 2-acyloxyethylsulfonamides V were obtained their structures confirmed by IR, ¹H-NMR, elemental analysis. The vitro vivo bioactivities against two...

Abstract In order to discover new antifungal agrochemicals that could have highly active and novel motifs, thirty-six 2-acylaminocycloalkylsulfonamides ( IV ) were synthesized. Their structures characterized confirmed by 1 H NMR, 13 C IR, MS, elemental analysis X-ray single crystal diffraction. vitro in vivo activities against various Botrytis cinerea strains evaluated. Bioassay results revealed most of the title compounds exhibited excellent fungicidal activity, which compound IV-26 showed...

To develop new fungicides with high efficiency, 46 novel sulfonamide derivatives were designed and synthesized by introducing pinacolone fragment into chesulfamide which was used as lead compound. All compounds characterized 1H NMR, 13C MS spectra, the structure of compound P-27 also confirmed X-ray single crystal diffraction. It found that a variety present excellent inhibitory effect against Botrytis cinerea. The inhibition rates P-29 on tomato strawberry 90.24% (200 mg/L) 100% (400 in...

N-(2-trifluoromethyl-4-chlorophenyl)-2-oxocyclohexyl sulfonamide (chesulfamide) is in the limelight as a novel fungicide, and has fungicidal activity against Botrytis cinerea. For exploring more structures, 33 new compounds were synthesized by N-alkylation acid-amine coupling reactions with chesulfamide core moiety, their structures characterized established ¹H-NMR, 13C-NMR, MS, elemental analysis. The structure of...

Abstract Famoxadone is a widely used chiral fungicide on tomato, apple, and grape. But it still being employed as racemic mixture without distinguishing the difference between enantiomers, which often leads to its inaccurate risk assessment. In this study, rapid, sensitive, reliable analytical method was developed for famoxadone enantiomers by ultra high performance liquid chromatography/tandem mass spectrometry, optimal separation condition achieved with Lux Amylose‐1 column using...