A5074229634- Insect and Pesticide Research
- Insect-Plant Interactions and Control
- Fungal Plant Pathogen Control
- Neurobiology and Insect Physiology Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Insect Pest Control Strategies
- Synthesis and biological activity
- Insect Resistance and Genetics
- Insect Utilization and Effects
- Plant and animal studies
- Plant biochemistry and biosynthesis
- Synthesis of Organic Compounds
- Insect and Arachnid Ecology and Behavior
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- Plant-Microbe Interactions and Immunity
- Parkinson's Disease Mechanisms and Treatments
- Insect Pheromone Research and Control
- Enzyme-mediated dye degradation
- Protein Interaction Studies and Fluorescence Analysis
- Plant Disease Resistance and Genetics
- Phytochemical compounds biological activities
- Studies on Chitinases and Chitosanases
China Agricultural University
2016-2025
Xinjiang Medical University
2014-2025
Shanghai Pesticide Research Institute
2025
State Forestry and Grassland Administration
2025
Second Affiliated Hospital of Xinjiang Medical University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Chinese PLA General Hospital
2023-2024
State Key Laboratory of Chemical Engineering
2024
Southwest Petroleum University
2023
China Tobacco
2019-2023
As important physiological regulators, peptides have been used in many fields including medicine, cosmetics, healthcare products, animal nutrition and health, plant protection. In recent years, become a popular research subject protection as antimicrobial immune inducers, growth insecticides, herbicides for their extensive raw material sources, excellent activity, ideal environmental compatibility. This paper briefly introduces peptide progress, presents an overview of studies protection,...
A competitive indirect enzyme-linked immunosorbent assay (ciELISA) using monoclonal antibodies (Mabs) having broad specificity for fluoroquinolone (FQ) antibiotics is described. Four FQs, ciprofloxacin (CIP), enrofloxacin (ENR), norfloxacin (NOR), and ofloxacin (OFL), were conjugated to bovine serum albumin immunogens ovalbumin coating antigens. Mab C4A9H1 raised against the CIP hapten exhibited high cross-reactivity (35−100%) with 12 of 14 FQs detected these in a ciELISA below their maximum...
Laccase is a novel target for fungicides. We previously developed new fungicide, 4-chlorocinnamaldehyde thiosemicarbazide (PMDD-5Y), as laccase inhibitor. The introduction of active groups natural products into the framework pesticide molecular structure an effective method discovering lead compounds, and it has applications in discovery pesticides. In this work, PMDD-5Y was selected compound, we designed synthesized series sulfonyl hydrazide derivatives containing product scaffold...
Abstract Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of grafts and decreased drug effectiveness in protease‐rich microenvironments. Here, multifunctional artificial (NIR‐mFAS) photothermal‐triggered delivery capabilities is designed actively comprehensively improve regenerative potential full‐thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix skin, cross‐linked by electrostatic interactions,...
The introduction of active groups natural products into the framework pesticide molecules is an effective approach for discovering lead compounds, and thus has been widely used in development new agrochemicals. In this work, a novel series 1,2,3,4-tetrahydroquinoline derivatives containing pyrimidine ether scaffold were designed synthesized by substructure splicing method. compounds showed good antifungal activities against several fungi. Especially, compound 4fh displayed excellent vitro...
Abstract BACKGROUND The emergence and increasing intensification of insect pest resistance greatly shortens the service life commercial insecticides. Hence, continuous development novel insecticides is extremely necessary. Discovering new insecticide molecules based on natural products with insecticidal activity has been a popular technique made outstanding contributions in this field. RESULTS A series betulin‐cinnamic acid‐related hybrid compounds was prepared by molecular hybridization...
Abstract Recent studies have strongly shown that cell‐to‐cell transmission of neuropathogenic proteins is a common mechanism for the development neurodegenerative diseases. However, underlying cause complex and little known. Although distinct processes are involved in pathogenesis various diseases, they all share feature iron accumulation, an attribute particularly prominent synucleinopathies. whether cofactor facilitating spread α‐synuclein remains unclear. Here, we constructed model using...
Abstract BACKGROUND Succinate dehydrogenase inhibitors (SDHIs) play an increasingly important role in controlling plant diseases. However, the similar structures of SDHIs result rapid development cross‐resistance and a clear bottleneck poor activity against oomycetes, therefore need to seek new SDHI fungicides with novel is urgent. RESULTS Innovative pyrazolyl oxime ethers were designed by replacing amide ether based on succinate (SDH) structure, 19 pairs Z ‐ E ‐isomers efficiently prepared...
Aphids have been mainly controlled by traditional chemical insecticides, resulting in unamiable risk to the environment over last decades. Push-pull strategy is regarded as a promising eco-friendly approach for aphid management through repelling away and attracting their natural enemy. Methyl salicylate (MeSA), one of typical HIPVs (herbivore-induced plant volatiles), can repel aphids attract ladybugs. Our previous studies discovered new lead compound 3e, salicylate-substituted carboxyl...
Remodeling the endogenous regenerative microenvironment in wounds is crucial for achieving scarless, functional tissue regeneration, especially recovery of skin appendages such as sweat glands burn patients. However, current approaches mostly rely on use exogenous materials or chemicals to stimulate cell proliferation and migration, while remodeling a pro-regenerative remains challenging. Herein, we developed flexible sono-piezo patch (fSPP) that aims create an promote repair wounds. This...
Abstract Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration‐directing artificial (RDAS) system presented, which based on the rational design of multi‐layered hydrogels that closely mimic natural matrices. By leveraging programmability and architectural rigidity DNA components, without need exogenous cell...
(E)-β-farnesene is a strong and efficient alarm pheromone in most aphid species. However, applications agriculture are prevented by its relatively high volatility, susceptibility to oxidation complex expensive synthesis. To develop novel compounds for control, we have designed synthesized analogues of (E)-β-farnesene, containing pyrazole moiety present several insecticides. Their structures been confirmed 1H NMR, elemental analysis, high-resolution mass spectroscopy IR. Binding activities...
A novel series of 1,3,4-oxadiazole derivatives containing a 5-phenyl-2-furan moiety were synthesized from the intermediates diacylhydrazine 3 and acylhydrazone 5 via an efficient approach under microwave irradiation in good yields. Their structures characterized by IR, (1)H NMR, elemental analysis. The antifungal tests indicated that title compounds showed vivo fungicidal activity against Botrytis cinerea Rhizoctonia solanii at 500 μg/mL obviously. Some tested even had superiority effect...
Abstract BACKGROUND The aphid alarm pheromone, ( E )‐β‐farnesene (EβF), is a natural product secreted from the cornicle as signal to warn companions of danger. Odorant binding proteins (OBPs) are vital targets in insect transduction pathways. To improve bioactivity EβF more economic and stable control agents, derivatives containing an active substructure, salicylic acid moiety, were designed, synthesized, evaluated for their bioactivities structure–function study under laboratory conditions....
Harmonia axyridis is an important natural enemy that consumes many agricultural and forestry pests. It relies on a sensitive olfactory system to find prey mates. Odorant-binding proteins (OBPs) as the first-step of recognizing volatiles, transport odors through sensillum lymph odorant receptors (ORs). However, little known about molecular mechanisms H. olfaction. In this study, four antenna specific OBP genes, HaxyOBP3 , 5 12 15 were bacterially expressed binding features recombinant 40...
Insect growth regulators (IGRs) disrupt normal development of physiological processes in insects and are recognized as green insecticides. chitinases play a crucial role cuticle degradation during molting, OfChtI, OfChtII, OfChi-h the prospective targets for discovering new insecticides IGRs. In our previous study, we identified lead compound a12 promising multitarget inhibitor. Herein, used binding modes with three to recognize critical interactions residues favorable bioactivity....
Insect growth regulators (IGRs) are important green insecticides that disrupt normal and development in insects to reduce the harm caused by pests crops. The ecdysone receptor (EcR) three chitinases
Insect neuropeptides play an essential role in regulating growth, development, reproduction, nerve conduction, metabolism, and behavior insects; therefore, G protein-coupled receptors of are considered important targets for designing green insecticides. Cockroach-type allatostatins (ASTs) (FGLamides allatostatins) insect Diploptera punctata that inhibit juvenile hormone (JH) synthesis the corpora allata affect reproduction insects. Therefore, pursuit novel insecticides targeting allatostatin...
Two series of novel 2,4-diphenyl-1,3-oxazolines containing an oxime ether moiety were designed and synthesized via the key intermediate N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide. The bioassay results showed that target compounds with substituent at para position 4-phenyl exhibited excellent acaricidal activity against Tetranychus cinnabarinus in laboratory. Moreover, all had much higher activities than etoxazole, as ovicidal larvicidal I-a-I-l II-a-II-n T. over 90% 0.001 mg L-1,...
In order to discover novel eco-friendly lead compounds for plant pathogenic fungi control, a series of benzaldehyde thiosemicarbazide derivatives with piperidine moiety have been designed and synthesized. Fungicidal activities all the synthesized were evaluated in vitro. The results indicated that title exhibited moderate good fungicidal activities. Compound 3b displayed excellent against Pythium aphanidermatum, Rhizoctonia solani, Valsa mali, Gaeu-mannomyces graminsis, EC50 values lower...
Our aim was to investigate the bioactivity and mode of action a novel fungicide 4-chlorocinnamaldehyde thiosemicarbazide (PMDD). As result its efficacy against various plant pathogens, protective fungicidal activity, systemic transport after root treatment, PMDD could be promising control wheat diseases. In field assay, showed good on take-all disease. A biochemical study indicated that acts as laccase inhibitor, date unique action. Moreover, total seven stable PMDD-resistant Gaeumannomyces...