A5101772482- Parkinson's Disease Mechanisms and Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Peroxisome Proliferator-Activated Receptors
- Copper-based nanomaterials and applications
- Alzheimer's disease research and treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Immune Response and Inflammation
- Nanocluster Synthesis and Applications
- Neurological Disease Mechanisms and Treatments
- Advanced Photocatalysis Techniques
- Neuroscience and Neuropharmacology Research
- Plant-derived Lignans Synthesis and Bioactivity
- Berberine and alkaloids research
- Ubiquitin and proteasome pathways
- Macrophage Migration Inhibitory Factor
- Adenosine and Purinergic Signaling
- Crystallography and molecular interactions
- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Ammonia Synthesis and Nitrogen Reduction
Guangzhou University of Chinese Medicine
2024-2025
China West Normal University
2024
Dalian University of Technology
2024
Guizhou Provincial People's Hospital
2024
Hospital for Sick Children
2024
Integrated Chinese Medicine (China)
2015-2022
Nanjing University
2015-2017
Inner Mongolia Medical University
2013-2016
Qingdao Municipal Center for Disease Control and Prevention
2014
Southern Medical University
2009
The NLR family pyrin domain containing 3 (NLRP3) inflammasome was reported to be regulated by autophagy and activated during inflammatory procession of Parkinson’s disease (PD). Berberine (BBR) is well-studied play an important role in promoting anti-inflammatory response mediate the activity. However, effect on NLRP3 PD its potential mechanisms remain unclear. Hence, this study, we investigated effects BBR 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice, evaluating their...
Abstract Recent studies have strongly shown that cell‐to‐cell transmission of neuropathogenic proteins is a common mechanism for the development neurodegenerative diseases. However, underlying cause complex and little known. Although distinct processes are involved in pathogenesis various diseases, they all share feature iron accumulation, an attribute particularly prominent synucleinopathies. whether cofactor facilitating spread α‐synuclein remains unclear. Here, we constructed model using...
Objective: To investigate the effect of acupuncture on Parkinson's disease (PD) patients with tremor and its potential neuromechanism by functional magnetic resonance imaging (fMRI). Methods: Forty-one PD were randomly assigned to true group (TAG, n=14), sham (SAG, n=14) waiting (WG, n=13). All received levodopa for 12 weeks. Patients in TAG acupunctured DU20, GB20 Chorea-Tremor Controlled Zone, SAG accepted acupuncture, while WG no treatment until weeks after course was ended. The UPDRS Ⅱ Ⅲ...
Alzheimer's disease (AD) is a common neurodegenerative disease, characterized by cognitive dysfunction; however, the therapeutic strategies are not fully understood. Huang-Lian-Jie-Du-Decoction (HLJDD) famous traditional Chinese herbal formula that has been widely used clinically to treat dementia. Recently, according previous study and our clinical practice, we generate new modification of HLJDD (named modified-HLJDD). In this study, indicated modified-HLJDD attenuated learning memory...
Clinically, the effective treatment for patients with acute ischemic stroke (AIS) is very limited. Therefore, this paper aims to investigate mechanism how astragalus polysaccharide (APS) exerts protective effect against AIS and provide a new method of AIS. Cell surface antigen flow cytometry immunofluorescence were used identify M1 M2 microglia. Western blot was evaluate expression associated protein. Oxygen-glucose deprivation (OGD) simulate on rat The middle cerebral artery occlusion...
Abstract Sensor accuracy is vital for effective structural health monitoring. However, due to the shear lag effect, strain transferred from structure sensor experiences some loss, which affects accuracy. This paper offers a review of transfer effects flexible sensors within Structural Health Monitoring (SHM), highlighting role that play in accurately detecting strain. A thorough understanding characteristics crucial improving measurement accuracy, especially complex and often harsh...
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses significant challenge to the health of global aging population. Despite extensive research, complex mechanisms underlying AD pathogenesis remain largely elusive. In recent years, growing number clinical studies have demonstrated preventive and therapeutic potential Traditional Chinese Medicine (TCM) against through multiple pathways, targets, compounds. this study, we conducted review literature published over past...
Migraine is one of the most common neurological diseases which has been treated by active substances from traditional Chinese medicine (TCM), such as ligustrazine, an extract herb Chuanxiong. However, pathogenesis migraine and curative mechanisms ligustrazine have remained unclear. The genes P2X3, TRPV1, ERK, c-fos implicated to play a role. In this work, we attempted elucidate analgesic mechanism using classic migraine-representative rat model.The model was established administration...
Purpose: Scoliosis is a complex spine deformity with direct functional and cosmetic impacts on the individual. The reference standard for assessing scoliosis severity Cobb angle which measured radiographs by human specialists, carrying interobserver variability inaccuracy of measurements. These limitations may result in lack timely referral management at time scoliotic progression can be saved from surgery. We aimed to create machine learning (ML) model automatic calculation angles 3-foot...
Objective To evaluate the safety and efficacy of removing blood stasis (RBS) herbal medicine for treatment acute intracerebral haemorrhage (AICH) within a 6-hour time window. Study design A randomised, multicentre, double-blind, placebo-controlled study performed in 14 hospitals China. Participants interventions Patients with AICH were randomly assigned to receive placebo, ICH-1 (Intracerebral Haemorrhage) formula (eight herbs, including RBS herbs hirudo tabanus ) or ICH-2 (six without 6...
The formation process and a typical FESEM image of AgCl hollow cubes.
Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons the substantia nigra (SN) Parkinson's disease (PD). Low-molecular-mass protein 7 (β5i) a proteolytic subunit immunoproteasome that regulates degradation and MHC pathway immune cells. In this study, we investigated role β5i DA using 6-hydroxydopamine (6-OHDA) model vitro vivo. We showed 6-OHDA upregulated concentration- time-dependent manner. Inhibition downregulation induced...
Hollow and porous nanoparticles of α-mercury sulfide (cinnabar) have been synthesized with thioacetamide mercury nitrate as precursors via a one-pot wet chemistry process. Scanning electron microscopy (SEM) transmission (TEM) show the presence plate-like hollow particles uniform diameters 70 ± 10 nm thicknesses 20 5 nm. Moreover, surfaces pore size 6 3 High-resolution TEM images highly ordered lattice fringes, indicating high crystallinity plates identifying product to be made α-HgS. A...
Parkinson's disease (PD) is the second most common neurodegenerative worldwide. Genetic factors play important roles in PD risk. rs653765 and rs514049 of ADAM10 were reported to be associated with Alzheimer's (AD) Caucasian population; however, association two variants Chinese Han population remains unknown. The present investigation aimed explore possible population.We enrolled 565 patients 518 healthy controls conduct a case-control study. DNA samples extracted from peripheral blood...