A5032265903- Parkinson's Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Genetic and Kidney Cyst Diseases
- Phytochemicals and Antioxidant Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Endoplasmic Reticulum Stress and Disease
- Soybean genetics and cultivation
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Legume Nitrogen Fixing Symbiosis
- Genomics, phytochemicals, and oxidative stress
- Monoclonal and Polyclonal Antibodies Research
- Phytochemicals and Medicinal Plants
- Chronic Kidney Disease and Diabetes
- Prion Diseases and Protein Misfolding
- Extraction and Separation Processes
- Biomedical Research and Pathophysiology
- Metabolism and Genetic Disorders
- Restless Legs Syndrome Research
Southern Medical University
2018-2025
Nanfang Hospital
2018-2025
Experimental Center of Forestry in North China
2023-2024
Qingdao Agricultural University
2024
Qingdao University of Science and Technology
2024
Zhengzhou University
2024
Jiangsu Academy of Agricultural Sciences
2024
Shanghai First People's Hospital
2023
Guangzhou Medical University
2017-2022
First Affiliated Hospital of Guangzhou Medical University
2017-2022
Mitochondrial fragmentation is a crucial mechanism contributing to tubular cell apoptosis during acute kidney injury (AKI). However, the of modulating mitochondrial dynamics AKI remains unclear. Numb multifunction adaptor protein that expressed in renal tubules. The aim present study was evaluate role dysfunction AKI.The expression upregulated both ischemia-reperfusion- and cisplatin-induced AKI. Depletion from proximal tubules (PT-Nb-KO) exacerbated shown as more severe damage higher serum...
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation has emerged as a central mediator of kidney inflammation in diabetic disease (DKD). However, the mechanism underlying this DKD remains poorly defined. In study, we found that kidney-enriched microRNA-10a -10b (miR-10a/b), predominantly expressed podocytes tubular epithelial cells, were downregulated from mice patients with DKD. High glucose decreased miR-10a/b expression vitro an osmolarity-independent manner....
Abstract Recent studies have strongly shown that cell‐to‐cell transmission of neuropathogenic proteins is a common mechanism for the development neurodegenerative diseases. However, underlying cause complex and little known. Although distinct processes are involved in pathogenesis various diseases, they all share feature iron accumulation, an attribute particularly prominent synucleinopathies. whether cofactor facilitating spread α‐synuclein remains unclear. Here, we constructed model using...
Objective: To investigate the effect of acupuncture on Parkinson's disease (PD) patients with tremor and its potential neuromechanism by functional magnetic resonance imaging (fMRI). Methods: Forty-one PD were randomly assigned to true group (TAG, n=14), sham (SAG, n=14) waiting (WG, n=13). All received levodopa for 12 weeks. Patients in TAG acupunctured DU20, GB20 Chorea-Tremor Controlled Zone, SAG accepted acupuncture, while WG no treatment until weeks after course was ended. The UPDRS Ⅱ Ⅲ...
Soybean [ Glycine max (L.)Merr.] is a leading oil-bearing crop and cultivated globally over vast scale. The agricultural landscape in China faces formidable challenge with drought significantly impacting soybean production. In this study, we treated natural population of 264 Chinese accessions using 15% PEG-6000 used GR, GE, GI, RGR, RGE, RGI ASFV as evaluation index. Using the ASFV, screened 17 strong drought-tolerant germplasm germination stage. Leveraging 2,597,425 high-density SNP...
Salt stress poses a significant challenge to crop productivity, and understanding the genetic basis of salt tolerance is paramount for breeding resilient soybean varieties. In this study, natural population was evaluated during germination stage, focusing on key traits, including rate (GR), energy (GE), index (GI). It seen that under stress, obvious inhibitions were found these with GR, GE, GI diminishing by 32% 54% when compared normal conditions. These traits displayed coefficient...
Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson's disease (PD) the toxic fibrillary α-syn binds lymphocyte-activation gene 3 (LAG3) receptor mediates transmission. The deletion LAG3 in animal models was shown limit spreading alleviate pathological changes dopaminergic neurons behavioral deficits induced by aggregation. However, little is known about genetic association variation with human PD development.
Trimethylamine-N-oxide (TMAO) is an intestinal metabolic toxin, which produced by gut flora via metabolizing high-choline foods. TMAO known to increase the risk of atherosclerosis and cardiovascular events in chronic kidney disease (CKD) patients.The objective this study was explore role mechanism aggravating injury.We used five-sixths nephrectomy (5/6 Nx)-induced CKD rats investigate whether could aggravate damage its possible mechanisms. Six weeks after operation, two groups 5/6 Nx were...
Patients with ulcerative colitis (UC) have higher rates of depression. However, the mechanism depression development remains unclear. The improvements EPA and DHA on dextran sulfate sodium (DSS)-induced UC been verified. Therefore, present study mainly focused effects UC-induced in C57BL/6 mice possible mechanisms involved. A forced swimming test tail suspension experiment showed that significantly improved DSS-induced depressive-like behavior. Further analysis demonstrated could suppress...
// Pei Yu 1, * , Chao Zhang Cai-Yun Gao 1 Ting Ma Hao Miao-Miao Zhou Yan-Wei Yang Lei and Ling-Yi Kong Jiangsu Key Laboratory of Bioactive Natural Product Research State Medicines, China Pharmaceutical University, Nanjing 210009, These authors have contributed equally to this work Correspondence to: Kong, email: cpu_lykong@126.com Yang, dorothy19802003@gmail.com Keywords: physagulide P, cell cycle arrest, apoptosis, autophagy, ROS/JNK Received: April 13, 2017    ...
Citrifurans A-D (1-4), metabolized by an Aspergillus sp., are unusual dimers of azaphilone and furanone derivatives. Michael addition was thought to be the pivotal procedure in their biosynthesis, different sites generated two new carbon skeletons. Their structures were elucidated on basis spectroscopic methods, single-crystal X-ray diffraction, chemical conversion, electronic circular dichroism analyses. Compounds 1-3 showed moderate inhibitory activities against LPS-induced NO production...
Aims: The risk factors promoting acute kidney injury (AKI) to chronic disease (CKD) progression remain largely unknown. aim of the present study was investigate whether hyperhomocysteinemia (Hhcy) accelerates development renal fibrosis after AKI. Results: Hhcy aggravated ischemia-reperfusion-induced AKI and subsequent fibrotic lesions characterized by excessive extracellular matrix deposition. Mechanistically, RNA binding protein human antigen R (HuR) bound 3′-untranslated region (3′-UTR)...
Rationale: Contactin-associated protein-like 4 (CNTNAP4) belongs to the neurexin superfamily and has critical functions in neurological development synaptic function. Loss of CNTNAP4 interneurons been linked autism, schizophrenia, epilepsy. is also highly enriched dopaminergic (DA) neurons substantia nigra (SN), however, few studies have investigated role DA neurons, whether deficiency contributes Parkinson's disease (PD) remains unclear. Methods: Effects knockdown or overexpression on MN9D...
A new withanolide (1), physagulide P, together with five known withanolides (2–6), was isolated from the aerial parts of Physalis angulata L. The structure compound elucidated on basis extensive spectroscopic techniques, including 1D, 2D NMR and HRESIMS. activity screening indicated that 1 showed significant cytotoxicities against human osteosarcoma cell line MG-63, HepG-2 hepatoma cells breast cancer MDA-MB-231 IC50 value 3.50, 4.22 15.74 μM.