A5035823003- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Gout, Hyperuricemia, Uric Acid
- Neurological disorders and treatments
- Pregnancy and preeclampsia studies
- Electrochemical sensors and biosensors
- Memory and Neural Mechanisms
- Neonatal Health and Biochemistry
- Case Reports on Hematomas
- Conducting polymers and applications
- Neonatal and Maternal Infections
- Metabolism and Genetic Disorders
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
- Diet and metabolism studies
- Blood disorders and treatments
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
Jinan University
2022-2024
First Affiliated Hospital of Jinan University
2024
Boai Hospital of Zhongshan
2018-2021
Southern Medical University
2017-2020
The First People's Hospital of Shunde
2017-2019
Huntington’s disease (HD) arises from the abnormal expansion of CAG repeats in huntingtin gene (HTT), resulting production mutant protein (mHTT) with a polyglutamine stretch its N-terminus. The pathogenic mechanisms underlying HD are complex and not yet fully elucidated. However, mHTT forms aggregates accumulates abnormally neuronal nuclei processes, leading to disruptions multiple cellular functions. Although there is currently no effective curative treatment for HD, significant progress...
The ketogenic diet (KD) is a low carbohydrate and high-fat protein diet. It plays protective role in neurodegenerative diseases by elevating the levels of ketone bodies blood, regulating central peripheral metabolism mitochondrial functions, inhibiting neuroinflammation oxidative stress, altering gut microbiota. However, studies on therapy for Parkinson's disease (PD) are still their infancy. Therefore, we examined possible effect KD 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...
Glutamate transporters play a key role in glutamate clearance and protect the central nervous system from excitotoxicity. Dysfunctional contribute to pathogenesis of Parkinson's disease (PD); however, mechanisms that underlie regulation PD are still not well characterized. Here we report Nedd4-2 mediates ubiquitination 1-methyl-4- phenylpyridinium (MPP+)-treated astrocytes midbrain 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-constructed model mice. Nedd4-2-mediated induces abnormal...
Evidence suggests that oxidative stress is involved in the pathogenesis of Parkinson disease (PD). Simvastatin has been suggested to protect against several diseases. However, molecular mechanisms by which simvastatin protects neuropathology and damage PD are poorly elucidated. In this study, we aimed investigate potential neuroprotective effects owing its anti-oxidative properties 6-hydroxydopamine (6-OHDA)-treated SH-SY5Y cells mice. The results 2', 7'-dichlorodihydrofluorescein diacetate...
Parkinson's disease (PD) features the degeneration and death of dopamine neurons in substantia nigra pars compacta formation Lewy bodies that contain α-synuclein. Among numerous PD etiologies, glutamate excitotoxicity is a research hot spot, transporters play key roles this theory. It has been shown expression transporter regulated by microRNAs. In study, we found levels function type 1 (GLT-1) were significantly reduced miR-543-3p was upregulated during development PD. Furthermore, our...
In China, the prevalence of HUA in Pearl River Delta (PRD) region Guangdong Province has not been extensively investigated. Therefore, this study investigated and its related factors among people aged 20-99 years nine cities PRD.We selected 6491 health check participants from 9 PRD collected participants' anthropometric biochemical test results for a cross-sectional study. We included assessed their blood pressure (BP), body mass index (BMI), total cholesterol (TC), triglycerides (TG),...
Transforming growth factor β-activated kinase 1 (TAK1), a vital upstream integrator of multiple pro-inflammatory signaling pathways, mediates the production cytokines, chemokines, and adhesion molecules. Investigations targeting TAK1 provide new therapeutic options for chronic inflammatory disorders, autoimmune diseases cancer. However, role mechanism inhibitor 5Z-7-oxozeaenol in treating demyelinating remain unclear. This work aimed to identify whether exerts neuroprotective effects on...
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT). This leads to production N-terminal mutant protein (mHtt) that contains expanded polyglutamine tract, which toxic neurons and causes neurodegeneration. While mHtt can be mediated proteolytic cleavage full-length mHtt, abnormal splicing exon1-intron1 has also been identified brains HD mice patients. However, proportion aberrantly spliced mHTT...
Our previous work has established a knockin (KI) pig model of Huntington's disease (HD) that can replicate the typical pathological features HD, including selective striatal neuronal loss, reactive gliosis, and axonal degeneration. However, HD KI mice exhibit milder neuropathological phenotypes lack overt neurodegeneration. By performing RNA sequencing to compare gene expression profiles between pigs mice, we find genes related interleukin-17 (IL-17) signaling are upregulated in brains...
To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy.Patients with a total 281 singleton pregnancies (including 38 patients preeclampsia) and 72 pregnancies, as well 42 who were not pregnant, included this study. We tested levels serum Cys C, creatinine, uric acid, along the estimated glomerular filtration rate (eGFR), different groups.The all 3 trimesters for women pregnancy much higher than those corresponding pregnancy. However, we observed little...
Huntington's disease (HD) is caused by an expansion of a CAG repeat in the gene that encodes huntingtin protein (HTT). The exact function HTT still not fully understood, and previous studies have mainly focused on identifying proteins interact with to gain insights into its function. Numerous HTT-interacting been discovered, shedding light functions structure HTT. Most these N-terminal region Among various proteins, huntingtin-associated 1 (HAP1) (HIP1) extensively studied. Recent...
Abstract Background: Hyperuricemia (HUA) has become the most common and serious public health problem worldwide. In China, prevalence of HUA in Pearl River Delta (PRD) region Guangdong Province not been extensively investigated. Therefore, this study investigated its related factors among people aged 20–99 years nine cities PRD. Methods: We selected 6491 check participants from 9 PRD collected participants’ anthropometric biochemical test results for a cross-sectional study. included...