A5058433072- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Organ Donation and Transplantation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Transplantation: Methods and Outcomes
- Neuroendocrine Tumor Research Advances
- Appendicitis Diagnosis and Management
- Neurological Complications and Syndromes
- Immune Response and Inflammation
- Renal and Vascular Pathologies
- Radiopharmaceutical Chemistry and Applications
- Endometriosis Research and Treatment
Université Libre de Bruxelles
2015-2024
Institut Jules Bordet
2015-2024
Erasmus Hospital
2009-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018
Creative Commons
2016
Institute of Pathology and Genetics
2009
Mie University Hospital
2009
Royal Belgian Society for Surgery
2007
Medico
2001-2006
Hôpital d'Hautepierre
2006
A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose not responding to medical therapy have a survival rate of approximately 30%. Since most deaths occur within 2 months, early transplantation attractive but controversial.We selected seven centers The had no prior episodes and scores 0.45 or higher according the Lille model (which calculates ranging 0 1, score ≥ indicating nonresponse an...
In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged an important player in the regulation T cell responses and promising target vaccination strategies. However, translation into clinical protocols been hampered by failure to identify humans. Here, we characterize population human that expresses DNGR-1 (CLEC9A) high levels BDCA3 resembles mouse phenotype function. We describe presence such spleens humans humanized mice report on protocol generate them vitro. Like DCs,...
The purpose of our study was to determine prospectively the value helical CT and various signs ischemia in context acute bowel obstruction.All patients seen over a 3-year period with diagnosis small-bowel obstruction were included. There 144 examinations 142 patients. Images interpreted consensus by fellow an experienced gastrointestinal radiologist. Attention focused on presence following strangulation ischemia: reduced enhancement wall, mural thickening, mesenteric fluid, congestion small...
The aim of our study was to examine, in a recent cohort kidney transplant recipients who have received modern immunosuppressive therapy, the respective role cold ischemia time (CIT) and delayed graft function (DGF) on acute rejection (AR) rates long-term survival.We retrospectively reviewed charts 611 renal transplantations between 1996 2005. Most patients calcineurin inhibitor as maintenance either cyclosporine (43%) or tacrolimus (52%) 76% an antilymphocyte induction therapy. Study...
The aim of this study was to evaluate the role fluorescence imaging (FI) using an intraoperative injection free indocyanine green (ICG) in detection peritoneal metastases (PM) due colorectal cancer (CRC).A large proportion patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy will have local recurrence. This is, part, related presence small undetected nodules cavity. Near-infrared FI-guided has provided new opportunities for nonvisible lesions during...
Abstract Background and Objectives To assess the value of FDG positron emission tomography (PET) for early detection incomplete tumor destruction after radiofrequency ablation (RFA) liver metastasis. Methods Twenty‐eight unresectable metastases in 17 patients were treated by RFA. Patients underwent computed (CT) FDG‐PET preoperatively, at 1 week, month, 3 months postoperatively. Postoperative CT week month analyzed to identify hypervascular hypermetabolic residual tumors RFA site. These...
In adhesive small bowel obstruction, the early recognition of complications such as strangulation or volvulus is essential to choose between surgical conservative initial treatment. The objective this study was determine prospectively contribution computed tomography (CT) decision making in management these patients.Patients with suspected obstruction had CT at admission. Patients signs and/or clinical peritoneal irritation underwent urgent surgery; other patients treatment.Fifty-four were...
There is evolving interest in the use of mesenchymal stem cells (MSC) solid organ transplantation. Pre-clinical transplantation models show efficacy MSC prolonging graft survival and a number clinical studies are planned or underway. At recent meeting MISOT consortium (MSC In Solid Organ Transplantation) advances these were evaluated mechanisms underlying potential effects discussed. Continued discussion required for definition safety eventually endpoints therapy
No intraoperative imaging techniques exist for detecting tumor nodules or scar tissues in patients treated with upfront interval cytoreductive surgery (CS) after neoadjuvant chemotherapy (NAC). The aims of this study were to evaluate the role indocyanine green (ICG) fluorescence (FI) detection peritoneal metastases (PM) and whether it can be used detect remnant cells tissue.Patients PM from ovarian cancer admitted CS included. ICG, at 0.25 mg per kg patient weight, was injected...
Abstract Background Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing immunogenic cell death, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT), have the potential to act synergistically with immunotherapy. For development new approaches combining locoregional treatments immunotherapy, better...
Abstract Background Secondary resection of initially unresectable colorectal cancer liver metastases (CRLM) can prolong survival. The added value selective internal radiotherapy (SIRT) to downsize lesions for is not known. This study evaluated the change in technical resectability CRLM with addition SIRT FOLFOX-based chemotherapy. Methods Baseline and follow-up hepatic imaging patients who received modified FOLFOX (mFOLFOX6: fluorouracil, leucovorin, oxaliplatin) chemotherapy or without...
Long-term results of organ transplantation are still limited by serious side effects immunosuppressive drugs. A major issue, therefore, is to elaborate novel therapeutic protocols allowing withdrawal or minimization therapy after transplantation. We report on 3 patients prospectively enrolled in an original protocol designed promote graft acceptance living donor liver transplantation, using posttransplant conditioning with high doses antithymocyte globulin followed injection donor-derived...