A5081798624- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Renal cell carcinoma treatment
- Genetic Neurodegenerative Diseases
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease and Transplantation
- Advanced X-ray and CT Imaging
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Gout, Hyperuricemia, Uric Acid
- Neuroscience and Neuropharmacology Research
Hôpitaux Universitaires Henri-Mondor
2012-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Hôpital Albert-Chenevier
2024
Hotel Dieu Hospital
2021
Cereep Ecotron Île-de-France
2021
Centre Hospitalier Universitaire Henri-Mondor
2019-2020
Paris-Est Sup
2014-2019
Université Paris-Est Créteil
2013-2019
Institut Mondor de Recherche Biomédicale
2012
Interim analysis of the DOSISPHERE-01 study demonstrated a strong improvement in response and overall survival (OS) on using <sup>90</sup>Y-loaded glass microspheres with personalized dosimetry compared standard patients nonoperable locally advanced hepatocellular carcinoma. This report sought to provide long-term OS. <b>Methods:</b> In this phase II (ClinicalTrials.gov identifier NCT02582034), treatment was randomly assigned (1:1) goal deliver either at least 205 Gy (if possible >250–300...
In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification altered metabolic pathways might be targeted therapeutically.We studied mice with activation liver (Apcko-liv mice) male C57Bl/6 given injections diethylnitrosamine, which each develop HCCs. Mice were fed a conventional or methionine-...
516 Background: 90Y loaded microsphere SIRT (radioembolization) is a treatment option in advanced HCC. However, no personalized dosimetric endpoints are currently used. The goal of this study was to compare the efficacy glass HCC using standard versus approach. Methods: DOSISPHERE-01 multicenter, randomized phase 2 trial unresectable patients with at least one tumor ≥7cm. Treatment arm randomly assigned (1:1) dosimetry (SDA), deliver 120±20Gy treated volume or (PDA) 205Gy index lesion....
This study evaluated the clinical impact of contrast-enhanced computed tomography (CECT) on routine management patients with lymphoma. Over a 1-year period, 237 CECT scans were performed prospectively in 163 after low-dose 18F-fluorodeoxyglucose positron emission tomography/computed (18F-FDG PET/CT). Scans at staging (n = 41), interim 73), post-therapy 115) and follow-up 8). Clinical was determined from multidisciplinary committee reports. had no 219 cases (92%). A clear noted only 3%, i.e....
To compare the apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) with standardized uptake values (SUV) measured by(18)F-FDG-PET/CT in naïve hepatocellular carcinoma (HCC) nodules, and to determine whether these markers are associated tumours at high-risk of aggressiveness.From 2007 2010, all patients HCC waiting list for liver transplantation who underwent both FDG-PET/CT 1.5-T DWI-MRI (b values: 0, 200, 400, 800 s/mm(2)) were included this institutional review...
Background Patients with aluminum hydroxide adjuvant-induced macrophagic myofasciitis (MMF) complain of arthromyalgias, chronic fatigue and cognitive deficits. This study aimed to characterize brain perfusion in these patients. Methods Brain SPECT was performed 76 consecutive patients (aged 49±10 y) followed the Garches-Necker-Mondor-Hendaye reference center for rare neuromuscular diseases. Images were acquired 30 min after intravenous injection 925 MBq 99mTc-ethylcysteinate dimer (ECD) at...
The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship cognitive dysfunction through use PET <sup>18</sup>F-FDG. <b>Methods:</b><sup>18</sup>F-FDG imaging a comprehensive battery neuropsychological tests were performed 100 consecutive MMF (age [mean ± SD], 45.9 12 y; 74% women). Images analyzed statistical parametric mapping (SPM12). Through analysis covariance, all <sup>18</sup>F-FDG images compared those...
Parkinsonian syndromes include typical cases of idiopathic Parkinson's disease (PD) and atypical parkinsonian (APS) associated with cognitive vegetative disorders, which are more challenging to diagnose. The aim this study was assess -the value dual-tracer imaging 6-fluoro-(18F)-L-DOPA (FDOPA) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), performed in routine patients demonstrating extrapyramidal signs complains, for the diagnosis management syndromes.We...
Whole-body positron emission tomography/magnetic resonance imaging (WB-PET/MRI) is increasingly used in oncology. However, chest staging remains challenging.To compare the diagnostic performance of a free-breathing 3D-T1-GRE stack-of-stars volume interpolated breath-hold examination (StarVIBE) with that (VIBE) during WB-PET/MRI for staging.Retrospective, cohort study.One hundred and twenty-three patients were referred initial solid cancer, 46 whom had pulmonary nodules 14...
Background: Selective internal radiation therapy (SIRT) is recommended as a downstaging (DS) strategy for solitary unresectable HCC <8 cm. The aim of this study was to report the results acquired experience in tertiary center all HCCs. Methods: We conducted retrospective, observational using data collected from consecutive patients undergoing SIRT between October 2013 and June 2020. DS considered achieved when curative treatment could be proposed 6 months after SIRT. Results: One hundred...
Optimal HCC therapeutic management relies on accurate tumor staging. Our aim was to assess the impact of 18F-FDG-WB-PET/MRI metastatic staging, compared with standard care CT-CAP/liver MRI combination, in patients referred a curative intent or before transarterial radioembolization. One hundred and four consecutive followed for were retrospectively included. The WB-PET/MRI combination pathology, followup, multidisciplinary board assessment as reference standard. Thirty metastases identified...
BACKGROUND. Assessment of hepatocellular carcinoma (HCC) treatment response after transarterial radioembolization (TARE) is challenging, because by conventional imaging criteria may not become apparent until 6 months treatment. Though HCC exhibits variable avidity for FDG, some cases without FDG show 18F-fluorocholine (18F-FCH). OBJECTIVE. The purpose this study was to evaluate the utility early posttreatment evaluation PET/CT using or 18F-FCH predict 6-month and survival TARE in patients...