A5087228377- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Organ Transplantation Techniques and Outcomes
- Gut microbiota and health
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Liver physiology and pathology
- HIV/AIDS drug development and treatment
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Pulmonary Hypertension Research and Treatments
- Glycosylation and Glycoproteins Research
- Veterinary medicine and infectious diseases
- Liver Diseases and Immunity
- Neurological Complications and Syndromes
- Cell Adhesion Molecules Research
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Clostridium difficile and Clostridium perfringens research
- Renal Transplantation Outcomes and Treatments
- Abdominal vascular conditions and treatments
Hôpital de la Timone
2016-2025
Assistance Publique Hôpitaux de Marseille
2014-2024
Aix-Marseille Université
2012-2023
Hôpital Nord
2023
Méditerranée Infection Foundation
2012-2023
Inserm
2007-2019
Université Paris-Saclay
2018
Centre de Recherche en Cancérologie de Marseille
2016
657 Oslo
2016
Hôpital de la Conception
2006-2015
The source and route of autochthonous hepatitis E virus (HEV) infections are not clearly established in industrialized countries despite evidence that it is a zoonosis pigs. We investigated the role figatellu, traditional pig liver sausage widely eaten France commonly consumed raw, as HEV infection.A case-control study was conducted 3 patients who presented 15 members their different families. Anti-HEV immunoglobulin G M antibody testing performed with commercial assays. RNA detected serum...
The efficacy of rifaximin in the secondary prevention overt hepatic encephalopathy (HE) is well documented, but its effectiveness preventing a first episode patients after transjugular intrahepatic portosystemic shunt (TIPS) has not been established.To determine whether prevents HE TIPS compared with placebo.Randomized, double-blind, multicenter, placebo-controlled trial. (ClinicalTrials.gov: NCT02016196).197 cirrhosis undergoing for intractable ascites or variceal rebleeding.Patients were...
Abstract Human microbiota-associated (HMA) mice are an important model to study the relationship between liver diseases and intestinal microbiota. We describe a new method humanize conventional based on bowel cleansing with polyethylene glycol followed by fecal microbiota transplantation (FMT) from human donor. Four successive cleansings were sufficient empty intestine decrease 90%. then compared four different strategies frequency of FMT over weeks: (1) twice week; (2) once (3) two FMTs;...
During January-March 2011, diagnoses of hepatitis E virus (HEV) infection increased in Marseille University hospitals southeastern France. HEV genotype 4, which is described almost exclusively Asia, was recovered from 2 persons who ate uncooked pork liver sausage. Genetic sequences were 96.7% identical to those recently swine Europe.
Reactivation of hepatitis B virus (HBV) infection in patients with past has been described 5% to 10% individuals undergoing immunosuppressive therapies. No data are available date on the outcome treated by tumour necrosis factor-alpha (TNFalpha) inhibitors for chronic arthritis a serological pattern HBV infection. The aim our study was monitor markers surface antigen (HBsAg)-negative/anti-HBcAb-positive TNFalpha inhibitor inflammatory arthritides.Twenty-one HBsAg-negative/anti-HBcAb-positive...
Summary. We studied clinical outcome and clinico-virological factors associated with hepatitis B virus reactivation (HBV-R) following cancer treatment in surface antigen (HBsAg)-negative/anti-hepatitis core antibodies (anti-HBcAb)-positive patients. Between 11/2003 12/2005, HBV-R occurred 7/84 HBsAg-negative/anti-HBcAb-positive patients treated for haematological or solid cancer. Virological including HBV genotype, promoter, precore, HBsAg genotypic amino acid (aa) patterns were studied....
Portopulmonary hypertension (PoPH) is diagnosed in 2‐6% of liver transplantation (LT) candidates. We studied outcomes candidates for LT suffering from PoPH. Data were collected retrospectively a prospective registry. Pulmonary hemodynamic variables at the time PoPH diagnosis, last evaluation before LT, and within 6 months beyond after LT. Forty‐nine patients (35 males, 48 ± 8 years) analyzed (median Model End‐Stage Liver Disease score 20). At baseline, mean pulmonary artery pressure (mPAP)...
Nonalcoholic steatohepatitis (NASH) increases with fructose consumption and metabolic syndrome has been recently linked endogenous ethanol production, notably by high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn). Candida yeasts are the main causes of auto-brewery syndromes but have neglected in NASH. Here, fecal microbial content 10 cases controls were compared. Ethanol was measured gas chromatography-mass spectrometry. Species identification performed MALDI-TOF MS, triglyceride...
Background Non-alcoholic steatohepatitis (NASH) has become a major public health issue as one of the leading causes liver disease and transplantation worldwide. The instrumental role gut microbiota is emerging but still under investigation. Endogenous ethanol (EtOH) production by bacteria yeasts an putative mechanism. Microbial metagenomics culture studies targeting enterobacteria or have been reported, no culturomics conducted so far. Aim To assess fecal EtOH other biochemical parameters,...
ABSTRACT Background and Aims The impact of bulevirtide in patients awaiting liver transplantation (LT) for decompensated disease and/or hepatocellular carcinoma (HCC) is unclear. We assessed clinical, virological, biochemical responses to with chronic hepatitis delta virus (HDV) LT compared outcomes a cohort similar untreated patients. Methods Consecutive HDV‐infected waiting since approval were included. Patients receiving 2 mg daily had biological, virological data collected at baseline,...
Background: Hepatitis B virus (HBV) infection is a global health epidemic that causes fatal complications, leading to liver cirrhosis and hepatocellular carcinoma. The link between HBV-related dysbiosis specific bacterial taxa still under investigation. Enterocloster emerging as new genus (formerly Clostridium), including bolteae, gut pathogen previously associated with human diseases such autism, multiple sclerosis, inflammatory bowel diseases. Its role in diseases, especially HBV...
Borentain, Patrick; Colson, Philippe; Bolon, Emilie; Gauchez, Coso, Diane; Gérolami, René Author Information