A5065460222- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Organ Transplantation Techniques and Outcomes
- Colorectal and Anal Carcinomas
- Genetic and Kidney Cyst Diseases
- Medical Imaging Techniques and Applications
- Transplantation: Methods and Outcomes
- Colorectal Cancer Screening and Detection
- Hernia repair and management
- Acute Myeloid Leukemia Research
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Adrenal and Paraganglionic Tumors
- Cancer Treatment and Pharmacology
- Hemodynamic Monitoring and Therapy
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
University Medical Center Groningen
2017-2025
University of Groningen
2018-2025
Amsterdam University Medical Centers
2024
University of Amsterdam
2024
Cancer Center Amsterdam
2024
Medisch Spectrum Twente
2022
Erasmus MC
2021
Imaging Center
2019
University Hospital Leipzig
2019
Assistance Publique – Hôpitaux de Paris
2007-2017
Although oncosurgical strategies have demonstrated increased survival in patients with unresectable colorectal liver metastases (CLM), their potential for cure is still questioned. The aim of this study was to evaluate long-term outcome after combining downsizing chemotherapy and rescue surgery define prognostic factors cure.All initially CLM who underwent had a minimum follow-up 5 years were included. Cure defined as disease-free interval > or = from last hepatic extrahepatic resection...
Transplantation of livers obtained from donors after circulatory death is associated with an increased risk nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion may reduce the incidence complications, but data prospective, controlled studies are limited.In this multicenter, trial, we randomly assigned patients who were undergoing transplantation a liver donor to receive that either hypothermic (machine-perfusion group) or conventional static cold storage alone (control...
In Brief Objective: To compare long-term outcome of R0 (negative margins) and R1 (positive liver resections for colorectal metastases (CLM) treated by an aggressive approach combining chemotherapy repeat surgery. Summary Background Data: Complete macroscopic resection with negative margins is the gold standard recommendation in surgical treatment CLM. However, due to vascular proximity or multinodularity, complete can sometimes only be performed through resection. Increasingly efficient may...
To assess feasibility, risks, and long-term outcome of 2-stage hepatectomy as a means to improve resectability colorectal liver metastases (CLM).Two-stage uses compensatory regeneration after first noncurative enable second curative resection.Between October 1992 January 2007, among 262 patients with initially irresectable CLM, 59 (23%) were planned for hepatectomy. Patients eligible when single resection could not achieve complete treatment, even in combination chemotherapy, portal...
Purpose Complete clinical response (CCR) of colorectal liver metastases (CLM) following chemotherapy is limited predictive value for complete pathologic (CPR) and cure the disease. The objective this study was to determine factors CPR as well its impact on survival. Patients Methods From January 1985 July 2006, 767 consecutive patients with CLM underwent resection after systemic chemotherapy. were compared without CPR. Results Twenty-nine (4%) had CPR, none these 29 CCR. (mean age, 54 years)...
Abstract Background This study evaluated the outcome of liver surgery for colorectal metastases (CLM) in patients over 70 years old a large international multicentre cohort. Methods Among 7764 who had resection CLM, 999 (12·9 per cent) were aged 70–75 years, 468 (6·0 75–80 and 157 (2·0 at least 80 old. Elderly compared with younger population. Results Multinodular bilateral less common elderly than (P < 0·001). Preoperative chemotherapy was used frequently more limited performed...
In patients with unresectable colorectal liver metastases (CLM) resistant to first-line chemotherapy, the impact of cetuximab therapy on resectability is unknown. This study was performed determine post-cetuximab rate and examine postoperative outcomes for these heavily pretreated patients.From February 2004 April 2006, we evaluated 151 CLM initial chemotherapy subsequently treated systemic cetuximab. Resectability rates, patient outcomes, tumoral nontumoral pathology were assessed.A total...
Purpose For patients with colorectal liver metastases (CLM), regional lymph node (RLN) involvement is one of the worst prognostic factors. The objective this study was to evaluate ability a multidisciplinary approach, including preoperative chemotherapy and hepatectomy, improve patient outcomes. Patients Methods Outcomes for consecutively treated group CLM simultaneous RLN were compared cohort without involvement. Univariate multivariate analysis clinical variables used identify factors in...
An expansion of resectability criteria colorectal liver metastases (CLM) is justified provided "acceptable" short-term and long-term outcomes. The aim the present study was to ascertain this paradigm in an era modern surgery.All consecutive patients who underwent hepatic resection for CLM at our institute between 1990 2010 were included study. Ninety-day mortality morbidity rates determined total population 2 separate time periods (group I: 1990-2000; group II: 2000-2010). Similarly, overall...
Abstract Background The optimal surgical strategy for patients with synchronous colorectal liver metastases (CLMs) is still unclear. aim of this study was to compare simultaneous and hepatic resection a delayed in who had limited hepatectomy (fewer than three segments). Methods All CLMs underwent between 1990 2006 were included retrospectively. Short-term outcome, overall progression-free survival compared having those treated by hepatectomy. Results Of 228 undergoing CLMs, 55 (24·1 per...
To evaluate the impact of location extrahepatic disease (EHD) on survival and to determine patient outcome in a consecutive series patients with both intrahepatic colorectal metastases treated by an oncosurgical approach, combining repeat surgery chemotherapy.Although recognized as poor prognostic factor, concomitant EHD is no more considered absolute contraindication liver (CLM). However, benefit still diversely appreciated.From 840 resected for CLM between 1990 2006, 186(22%) also had...
Coronavirus disease 2019 (COVID-19) is a contagious life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk for kidney injury during COVID-19 infection. The pathophysiologic mechanisms leading to in are unclear but may include direct cytopathic effects of virus on tubular and endothelial cells, indirect damage virus-induced cytokine release, hypoperfusion due restrictive fluid strategy. In this report...
AimThis multi-centre prospective cohort study aimed to investigate non-inferiority in patients' overall survival when treating potentially resectable colorectal cancer liver metastasis (CRLM) with stereotactic microwave ablation (SMWA) as opposed hepatic resection (HR).MethodsPatients no more than 5 CRLM larger 30 mm, deemed eligible for both SMWA and at the local multidisciplinary team meetings, were deliberately treated (study group). The contemporary control group consisted of patients...
Pheochromocytomas and paragangliomas have up to a 20% rate of metastatic disease that cannot be reliably predicted. This study prospectively assessed whether the dopamine metabolite, methoxytyramine, might predict disease, predictions improved using machine learning models incorporate other features, how learning-based compare with made by specialists in field.
Abstract Background Portal vein embolization (PVE) increases the resectability of initially unresectable colorectal liver metastases (CLM). This study evaluated long-term survival in patients with CLM who underwent hepatectomy following PVE. Methods In a retrospective analysis treated by PVE before major were compared those did not have PVE, and had without resection. Results Of 364 hepatectomy, 67 beforehand 297 not. Those more often than three (68 versus 40·9 per cent; P < 0·001)...
Abstract Background Multidisciplinary team (MDT) meetings have been adopted widely to ensure optimal treatment for patients with cancer. Agreements in tumour staging, resectability assessments and allocation between different MDTs were assessed. Methods Of all referred one hospital, 19 considered non-metastatic pancreatic cancer evaluation selected randomly a multicentre study of MDT decisions seven units across Northern Europe. Anonymized clinical information radiological images...
Abstract Background and Aim Portal vein thrombosis (PVT) is a common complication of cirrhosis. The exact pathophysiology remains largely unknown, treatment with anticoagulants does not lead to recanalization the portal in all patients. A better insight into structure composition thrombi may assist developing strategies for prevention PVT. Approach Results Sixteen prospectively 63 retrospectively collected nonmalignant from patients cirrhosis who underwent liver transplantation were...
Regenerative nodular hyperplasia (RNH) represents the end-stage of vascular lesions liver induced by chemotherapy. The goal was to evaluate its incidence and impact on outcome patients resected for colorectal metastases (CLM).Patients who underwent hepatectomy CLM after six cycles or more first-line chemotherapy, between January 1990 November 2006, were included. Detailed histopathologic analysis nontumoral performed according a standard format.From cohort 856 at our institution, 771 (90%)...
The salvage liver transplantation (SLT) strategy was conceived for initially resectable and transplantable (R&T) hepatocellular carcinoma (HCC) patients, to try obviate upfront transplantation, with the “safety net” of SLT in case postresection recurrence. is successful or curative when patients are recurrence free following primary resection alone, after aim current study determine strategy's potential cure R&T HCC identify predictors its success. From 1994 2012, all cirrhosis were...
Deep learning has been proven to be able stage liver fibrosis based on contrast-enhanced CT images. However, until now, the algorithm is used as a black box and lacks transparency. This study aimed provide visual-based explanation of diagnostic decisions made by deep learning.The staging network (LFS network) was developed at images in portal venous phase 252 patients with histologically stage. To give visual LFS network, Gradient-weighted Class Activation Mapping (Grad-cam) produce location...
The Mayo Imaging Classification was developed to predict the rate of disease progression in patients with autosomal dominant polycystic kidney disease. This study aimed validate its ability outcomes a large multicenter cohort.