A5010056388- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Colorectal Cancer Treatments and Studies
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Animal testing and alternatives
- Redox biology and oxidative stress
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Tryptophan and brain disorders
- Cancer therapeutics and mechanisms
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Pancreatic and Hepatic Oncology Research
- Regulation of Appetite and Obesity
- Sulfur Compounds in Biology
- Cancer Treatment and Pharmacology
- Sphingolipid Metabolism and Signaling
Hôpital Paul-Brousse
2002-2024
Biocodex (France)
2023-2024
Assistance Publique – Hôpitaux de Paris
2007-2024
Porsolt (France)
2014-2023
Laboratoire Vision Action Cognition
2012
Inserm
1987-2007
University of Lausanne
1996-2004
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2004
Hôpital de Cery
2002
Nestlé (Switzerland)
1993-1996
The development of antidepressants requires simple rodent behavioral tests for initial screening before undertaking more complex preclinical and clinical evaluation. Presented in the unit are two widely used antidepressants, forced swim (also termed despair) test rat mouse, tail suspension mouse. These have good predictive validity allow rapid economical detection substances with potential antidepressant-like activity. despair based on same principle: measurement duration immobility when...
Abstract The development of antidepressants requires simple rodent behavioral tests for initial screening before undertaking more complex preclinical and clinical evaluation. Presented in the unit are two widely used antidepressants, forced swim (also termed despair) test rat mouse, tail suspension mouse. These have good predictive validity allow rapid economical detection substances with potential antidepressant‐like activity. despair based on same principle: measurement duration immobility...
In patients with unresectable colorectal liver metastases (CLM) resistant to first-line chemotherapy, the impact of cetuximab therapy on resectability is unknown. This study was performed determine post-cetuximab rate and examine postoperative outcomes for these heavily pretreated patients.From February 2004 April 2006, we evaluated 151 CLM initial chemotherapy subsequently treated systemic cetuximab. Resectability rates, patient outcomes, tumoral nontumoral pathology were assessed.A total...
While high risk of failure is an inherent part developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union’s Innovative Medicines Initiative, EQIPD consortium has developed a novel preclinical quality system that applied in both public and private sectors free for anyone use. The Quality System was designed suited boost innovation ensuring generation robust reliable data while being lean, effective not...
The recent development of immunotherapy represents a significant breakthrough in cancer therapy. Several immunotherapies provide robust efficacy gains wide variety cancers. However, some patients the immune checkpoint blockade remains ineffective due to poor therapeutic response and tumor relapse. An improved understanding mechanisms underlying tumor-immune system interactions can improve clinical management cancer. Here, we report preclinical data evaluating two murine antibodies...
Schizophrenia is characterized by three major symptom classes: positive symptoms, negative and cognitive deficits. Classical antipsychotics (phenothiazines, thioxanthenes, butyrophenones) are effective against symptoms but induce side effects, in particular, extrapyramidal (EPS). The discovery of clozapine, which does not EPS thought all classes symptom, has driven research for novel with a wider activity spectrum lower liability. To increase predictiveness, current efforts aim to develop...
Most, if not all, guidelines, recommendations, and other texts on Good Research Practice emphasize the importance of blinding randomization. There is, however, very limited specific guidance when how to apply This chapter aims disambiguate these two terms by discussing what they mean, why are applied, conduct acts randomization blinding. We discuss use as means against existing potential risks bias rather than a mandatory practice that is be followed under all circumstances at any cost....
Surgery followed by a chemotherapy agent is the first-line treatment for breast cancer patients. Nevertheless, new targets are required women with triple-negative (TNBC) in order to improve of this aggressive subtype. Multiple pro-inflammatory molecules including lipid-based substances such as sphingosine-1-phosphate (S1P) promote progression. In preclinical study, we aim investigate efficacy Fingolimod, an inhibitor S1P / receptors axis, already approved immunomodulator multiple sclerosis....
Developing neurons die when deprived of trophic support from their axonal target. Although this is generally attributed to the programmed expression suicide proteins, recent data suggest that a less orderly mechanism involving oxidative stress may also be involved. We have studied retinal ganglion cell death in chick embryo after contralateral tectal lesion. The kinetics death, as judged counts pyknotic cells, are described. In addition, we show reduced following intraocular injections...
Abstract Glutathione is a major regulator of the redox equilibrium, so its deficit weakens tissue resistance to oxidants. The nervous system particularly susceptible oxidative insults and therefore very dependent on glutathione content, especially during development, when brain metabolism growth are maximal. In addition, various pathologies affecting involve stress, possibly associated with diminution concentrations. To study involvement in homeostasis, we set up an experimental model...