A5036154200- Cardiac electrophysiology and arrhythmias
- Animal testing and alternatives
- Ion channel regulation and function
- Computational Drug Discovery Methods
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Biosimilars and Bioanalytical Methods
- Biomedical Ethics and Regulation
- Cell Image Analysis Techniques
- Veterinary Pharmacology and Anesthesia
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Vascular Tumors and Angiosarcomas
- Clinical practice guidelines implementation
- Electron Spin Resonance Studies
- Neurogenesis and neuroplasticity mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Conducting polymers and applications
- Plant Pathogens and Resistance
- Alzheimer's disease research and treatments
- Health and Medical Research Impacts
- Biochemical effects in animals
Sanofi (France)
2015-2021
Centre National de la Recherche Scientifique
1989-1996
Hôpital Marie Lannelongue
1996
Université Paris-Sud
1991
Laboratoire d’Ethologie Expérimentale et Comparée
1989
Université Paris-Saclay
1989
Royal Brisbane and Women's Hospital
1986
The University of Queensland
1986
While high risk of failure is an inherent part developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union’s Innovative Medicines Initiative, EQIPD consortium has developed a novel preclinical quality system that applied in both public and private sectors free for anyone use. The Quality System was designed suited boost innovation ensuring generation robust reliable data while being lean, effective not...
Over the last two decades, awareness of negative repercussions flaws in planning, conduct and reporting preclinical research involving experimental animals has been growing. Several initiatives have set out to increase transparency internal validity studies, mostly publishing expert consensus experience. While many points raised these various guidelines are identical or similar, they differ detail rigour. Most them focus on reporting, only few cover planning studies. The aim this systematic...
1. The whole‐cell voltage‐clamp technique was applied to isolated rat ventricular myocytes investigate the effects of D600 (10(‐9)‐10(‐3) M) on intracellular calcium‐independent component transient outward current. I(lo), recorded in a sodium‐free medium containing 0.5 x 10(‐3) M‐cadmium and 10(‐6) M‐ryanodine. 2. Externally reduced Ilo dose‐dependent, reversible manner, accelerated decay 3. Current‐voltage relationships corresponding activation curves (determined assuming I(lo) be pure...
Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked cognitive symptoms that precede neuronal neurodegeneration. Neurogranin (Ng) a somatodendritic protein has been shown reduced brain tissue but increased the cerebrospinal fluid (CSF) AD patients compared age-matched controls. High levels CSF Ng have reflect more rapid progression. To gauge translational value as biomarker, we developed new, highly sensitive, digital...
Thorotrast, once a popular radiographic contrast medium, is associated with an increased incidence of angiosarcoma, cholangiocarcinoma and hepatocellular carcinoma about 10 to 30 years after administration. Use Thorotrast was discontinued in the 1950s primarily because concern potential long-term radiation effects. A 59-year-old female had received prior administration for investigation right-sided cerebrovascular accident 1952. She admitted 1984 evaluation right upper quadrant pain,...
While high risk of failure is an inherent part developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted date have clearly identified measures that need taken improve rigor. Supported through the European Union’s Innovative Medicines Initiative, EQIPD consortium has developed a novel preclinical quality system applied in both public and private sectors free for anyone use. The Quality System was designed suited...
Thousands of pharmacology experiments are performed each day, generating hundreds drug discovery programs, scientific publications, grant submissions, and other efforts. Discussions the low reproducibility robustness some this research have led to myriad efforts increase data quality thus reliability. Across ecosystem, regardless extent concerns, debate about solutions, differences among goals practices, scientists strive provide reliable advance frontiers knowledge. Here we share our...