Sabine Grote
A5069337144- Animal testing and alternatives
- Viral Infectious Diseases and Gene Expression in Insects
- Health and Medical Research Impacts
- Immunotoxicology and immune responses
- Meta-analysis and systematic reviews
- Engineering Technology and Methodologies
- Computational Drug Discovery Methods
AbbVie (Germany)
2022
Over the last two decades, awareness of negative repercussions flaws in planning, conduct and reporting preclinical research involving experimental animals has been growing. Several initiatives have set out to increase transparency internal validity studies, mostly publishing expert consensus experience. While many points raised these various guidelines are identical or similar, they differ detail rigour. Most them focus on reporting, only few cover planning studies. The aim this systematic...
Digital toxicologic histopathology has been broadly adopted in preclinical compound development for informal consultation and peer review. There is now increased interest implementing the technology good laboratory practice-regulated study evaluations. However, implementation not straightforward because systems work processes require qualification validation, with consideration also given to security. As a result of high-throughput, high-volume nature safety evaluations, computer...