A5051580402- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
- Protease and Inhibitor Mechanisms
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Psoriasis: Treatment and Pathogenesis
- Glioma Diagnosis and Treatment
- TGF-β signaling in diseases
- Galectins and Cancer Biology
- Axon Guidance and Neuronal Signaling
- Platelet Disorders and Treatments
- Fibroblast Growth Factor Research
- Angiogenesis and VEGF in Cancer
- NF-κB Signaling Pathways
- Chemokine receptors and signaling
- Dermatology and Skin Diseases
- Immunotoxicology and immune responses
Porsolt (France)
2018-2024
Inserm
2013-2018
Université de Strasbourg
2014-2018
Immuno-Rhumathologie moléculaire
2015
Bipar
2015
Abstract Tenascin-C is an extracellular matrix molecule that drives progression of many types human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes cancer cell migration in tumor microenvironment. murine xenograft model advanced osteosarcoma, and receptor integrin α9β1 were determined to be essential lung metastasis cells. We activation pathway also reduced cell–autonomous expression...
High expression of the extracellular matrix component tenascin-C in tumor microenvironment correlates with decreased patient survival. Tenascin-C promotes cancer progression and a disrupted vasculature through an unclear mechanism. Here, we examine angiomodulatory role tenascin-C. We find that direct contact endothelial cells disrupts actin polymerization, resulting cytoplasmic retention transcriptional coactivator YAP. also downregulates YAP pro-angiogenic target genes, thus reducing cell...
The recent development of immunotherapy represents a significant breakthrough in cancer therapy. Several immunotherapies provide robust efficacy gains wide variety cancers. However, some patients the immune checkpoint blockade remains ineffective due to poor therapeutic response and tumor relapse. An improved understanding mechanisms underlying tumor-immune system interactions can improve clinical management cancer. Here, we report preclinical data evaluating two murine antibodies...
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression linked to poor prognosis in several cancers.To provide comprehensive understanding TNC's functions cancer, we established an immune-competent transgenic mouse model pancreatic b-cell carcinogenesis with varying levels compared stochastic neuroendocrine tumor formation abundance or absence TNC.We show that promotes cell survival, angiogenic switch, more leaky vessels,...
// Benoit Langlois 1, 2, 3, 4, * , Falk Saupe Tristan Rupp 4 Christiane Arnold Michaël van der Heyden Gertraud Orend Thomas Hussenet 1 Inserm U1109, MN3T team, Molière, Strasbourg, 67200, France 2 Université de 67000, 3 LabEx Medalis, Fédération Médecine Translationnelle Strasbourg (FMTS), These authors contributed equally to this work Correspondence to: Orend, e-mail: gertraud.orend@inserm.fr Hussenet, hussenetthomas@gmail.com Keywords: Tumor angiogenesis, angiogenic switch, extracellular...
Surgery followed by a chemotherapy agent is the first-line treatment for breast cancer patients. Nevertheless, new targets are required women with triple-negative (TNBC) in order to improve of this aggressive subtype. Multiple pro-inflammatory molecules including lipid-based substances such as sphingosine-1-phosphate (S1P) promote progression. In preclinical study, we aim investigate efficacy Fingolimod, an inhibitor S1P / receptors axis, already approved immunomodulator multiple sclerosis....
Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- disease-associated matrix components with pro- anti-adhesive activity, respectively. Whereas both present in the tumour vasculature, their functional interplay on vascular endothelial cells remains unclear. We have previously shown that basally-oriented deposition of a FN restricts motility promotes junctional stability cultured this effect is tightly coupled to expression FN. Here we report TNC induces cells. This...
Tumor stroma remodeling is a key feature of malignant tumors and can promote cancer progression. Laminins are major constituents basement membranes that physically separate the epithelium from underlying stroma.
Glioblastomas are malignant brain tumors which remain lethal due to their aggressive and invasive nature. The standard treatment combines surgical resection, radiotherapy, chemotherapy using Temozolomide, albeit with a minor impact on patient prognosis (15 months median survival). New therapies evaluated in preclinical translational models therefore still required improve survival quality of life. In this study, we the effect Temozolomide different glioblastoma. We also aimed investigate...
Ethical considerations, cost, and time constraints have highlighted the need to develop alternatives rodent in vivo models for evaluating drug candidates cancer. The tumor chicken chorioallantoic membrane (TCAM) model provides an affordable fast assay that permits direct visualization of progression. Tumors from multiple species including rodents human cell lines can be engrafted. In this study, we engrafted several onto CAM demonstrated TCAM is alternative mouse preliminary cancer efficacy...
New therapies are required for patients with non-small cell lung cancer (NSCLC) which the current standards of care poorly affect patient prognosis this aggressive subtype. In preclinical study, we aim to investigate efficacy Fingolimod, a described inhibitor sphingosine-1-phosphate (S1P)/S1P receptors axis, and Dimethyl Fumarate (DMF), methyl ester fumaric acid, both already approved as immunomodulators in auto-immune diseases additional expected anti-cancer effects. The impact drugs was...
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, inflammation, and aberrant differentiation. Imiquimod-induced psoriasis in rodent models has been widely used to study the pathogenesis of disease evaluate potential therapeutic interventions. In this study, we investigated efficacy two commonly treatments, Clobetasol Tacrolimus, ameliorating psoriatic symptoms an Wistar rat model. Interestingly, are poorly evaluated literature despite rats...
Summary Tumor stroma remodeling is a key feature of malignant tumors and can promote cancer progression. Laminins are major constituents basement membranes that physically separate the epithelium from underlying stroma. By employing mouse models expressing high low levels laminin α1 chain (LMα1), we highlighted its implication in tumorstroma crosstalk, thus leading to increased colon tumor incidence, angiogenesis growth. The mechanism involves attraction carcinoma-associated fibroblasts by...
<div>Abstract<p>Tenascin-C is an extracellular matrix molecule that drives progression of many types human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes cancer cell migration in tumor microenvironment. murine xenograft model advanced osteosarcoma, and receptor integrin α9β1 were determined to be essential lung metastasis cells. We activation pathway also reduced...
<p>KRIB cell migration on FN</p>
<p>KRIB cell migration on FN/TNC</p>
<p>Supplementary data</p>
<p>Supplementary data</p>
<p>KRIB cell migration on FN/TNC</p>
<p>KRIB cell migration on FN</p>
<div>Abstract<p>Tenascin-C is an extracellular matrix molecule that drives progression of many types human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes cancer cell migration in tumor microenvironment. murine xenograft model advanced osteosarcoma, and receptor integrin α9β1 were determined to be essential lung metastasis cells. We activation pathway also reduced...
Introduction The recent development of immunotherapy represents a significant breakthrough in cancer therapy. Several immunotherapies provide robust efficacy gains wide variety cancers. However, some patients immune checkpoint blockade remains ineffective due to absence therapeutic response, tumour relapse, and high severity adverse drug reactions. An improved comprehension the basic mechanisms underlying tumor-immune system interactions may improve clinical management cancer. Here, we...