A5071595925- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Sphingolipid Metabolism and Signaling
- Cancer therapeutics and mechanisms
- Analytical Methods in Pharmaceuticals
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Antibiotics Pharmacokinetics and Efficacy
- Inflammatory Bowel Disease
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Ion channel regulation and function
- Glioma Diagnosis and Treatment
- Veterinary Pharmacology and Anesthesia
- Cardiomyopathy and Myosin Studies
- Colorectal and Anal Carcinomas
- Pharmaceutical Economics and Policy
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Diagnosis and treatment of tuberculosis
- Cardiac Arrhythmias and Treatments
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
Porsolt (France)
2010-2023
The recent development of immunotherapy represents a significant breakthrough in cancer therapy. Several immunotherapies provide robust efficacy gains wide variety cancers. However, some patients the immune checkpoint blockade remains ineffective due to poor therapeutic response and tumor relapse. An improved understanding mechanisms underlying tumor-immune system interactions can improve clinical management cancer. Here, we report preclinical data evaluating two murine antibodies...
Surgery followed by a chemotherapy agent is the first-line treatment for breast cancer patients. Nevertheless, new targets are required women with triple-negative (TNBC) in order to improve of this aggressive subtype. Multiple pro-inflammatory molecules including lipid-based substances such as sphingosine-1-phosphate (S1P) promote progression. In preclinical study, we aim investigate efficacy Fingolimod, an inhibitor S1P / receptors axis, already approved immunomodulator multiple sclerosis....
Glioblastomas are malignant brain tumors which remain lethal due to their aggressive and invasive nature. The standard treatment combines surgical resection, radiotherapy, chemotherapy using Temozolomide, albeit with a minor impact on patient prognosis (15 months median survival). New therapies evaluated in preclinical translational models therefore still required improve survival quality of life. In this study, we the effect Temozolomide different glioblastoma. We also aimed investigate...
Ethical considerations, cost, and time constraints have highlighted the need to develop alternatives rodent in vivo models for evaluating drug candidates cancer. The tumor chicken chorioallantoic membrane (TCAM) model provides an affordable fast assay that permits direct visualization of progression. Tumors from multiple species including rodents human cell lines can be engrafted. In this study, we engrafted several onto CAM demonstrated TCAM is alternative mouse preliminary cancer efficacy...
In vitro electrophysiological safety studies have become an integral part of the drug development process since, in many instances, compound-induced QT prolongation has been associated with a direct block human ether-a-go-go-related gene (hERG) potassium channels or its native current, rapidly activating delayed rectifier current (I(Kr)). Therefore, hERG channel patch-clamp assay is commonly used as early screen to predict ability compound prolong interval. The protocol described this unit...