A5067606739- Cell Adhesion Molecules Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Blood properties and coagulation
- Phagocytosis and Immune Regulation
- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Reproductive System and Pregnancy
- Rheumatoid Arthritis Research and Therapies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Oral microbiology and periodontitis research
- Trace Elements in Health
- Immune Cell Function and Interaction
- Biomarkers in Disease Mechanisms
- Viral gastroenteritis research and epidemiology
- Oral Health Pathology and Treatment
- Immune responses and vaccinations
University of Oxford
2017-2023
Institute of Rheumatology
2023
NIHR Oxford Musculoskeletal Biomedical Research Centre
2023
Nuffield Orthopaedic Centre
2018-2021
Cardiff University
2021
Aarhus University
2017
Jagiellonian University
2017
Abstract Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection increasingly well defined mechanistically, but discrimination endogenous inflammatory triggers remains unclear. Tenascin-C, a matrix protein induced upon tissue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammation. Here we map three sites...
The interplay between cancer cells and immune is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties extracellular matrix to create microenvironment that enables their escape from surveillance. Using orthotopic grafting mammary in immunocompetent mice autochthonous models breast cancer, discovered tenascin-C, molecule absent most healthy adult tissues but expressed at high levels associated with poor patient prognosis many solid cancers,...
Objective In addition to the long‐established link with smoking, periodontitis ( PD ) is a risk factor for rheumatoid arthritis RA ). This study was undertaken elucidate mechanism by which could induce antibodies citrullinated peptides ACPA s), examining antibody response novel peptide of cytokeratin 13 CK ‐13) identified in gingival crevicular fluid GCF ), and comparing 4 other patients who were well‐characterized smoking. Methods The citrullinomes periodontal tissue from mapped mass...
The pentraxin serum amyloid P component (SAP) is secreted by the liver and found in plasma at a concentration of approximately 30 mg/L. SAP 25 kDa homopentamer known to bind both protein nonprotein ligands, all calcium-dependent manner. function unclear but likely involves humoral innate immune system spanning complement system, inflammation, coagulation. Also, generic structure deposits possibly protect them against proteolysis. In this study, we have characterized interactome human...
<div>Abstract<p>The interplay between cancer cells and immune is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties extracellular matrix to create microenvironment that enables their escape from surveillance. Using orthotopic grafting mammary in immunocompetent mice autochthonous models breast cancer, discovered tenascin-C, molecule absent most healthy adult tissues but expressed at high levels associated with poor patient...
<p>Supplementary figures and table</p>
<p>Supplementary figures and table</p>
<div>Abstract<p>The interplay between cancer cells and immune is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immunomodulatory properties extracellular matrix to create microenvironment that enables their escape from surveillance. Using orthotopic grafting mammary in immunocompetent mice autochthonous models breast cancer, discovered tenascin-C, molecule absent most healthy adult tissues but expressed at high levels associated with poor patient...